Abstract: A fermented extract of aerial parts of Citrus aurantium and the process for obtaining it. The fermented extract may be added to a cosmetic composition. Also, the use of a fermented extract of Citrus aurantium to combat skin ageing, and also as an antioxidant active agent, to prevent/reduce oxidative stress and/or to detoxify the skin.

Abstract: A fermented extract of aerial parts of Citrus aurantium and the process for obtaining it. The fermented extract may be added to a cosmetic composition. Also, the use of a fermented extract of Citrus aurantium to combat skin ageing, and also as an antioxidant active agent, to prevent/reduce oxidative stress and/or to detoxify the skin.

Abstract: The disclosure relates to the identification and the use of compounds which regulate the expression of at least one Sestrin gene, for preventing and/or attenuating skin ageing, and/or for hydrating the skin and/or for regulating skin pigmentation. The method includes the following steps: a. bringing at least one test compound in contact with a sample of human keratinocytes or melanocytes; b. measuring the expression of at least one Sestrin gene chosen from SESN3, SESN2 and SESN1 in the keratinocytes or melanocytes; c. selecting the compounds for which an activation of at least 1.6 fold of the expression of at least one of the genes is measured in the keratinocytes treated in a. compared with the untreated keratinocytes, or for which a significant modulation of the expression of at least one of the genes is measured in the melanocytes treated in a. compared with the untreated melanocytes.

Abstract: Disclosed are methods for screening for candidate compounds for hydrating the skin. The compounds selected according to the methods disclosed therein stimulate the intra-cellular amount and/or activity of TonEBP in keratinocytes. Preferably, the selected compounds induce a stimulation of at least 20%, preferably at least 50%, preferably at least 100% of the activity and/or intra-cellular amount of TonEBP.

Abstract: Disclosed is an alcoholic extract of aerial parts of Anthyllis vulneraria, method for obtaining same, a cosmetic or dermatological composition containing same, as well as the cosmetic and dermatological uses thereof, in particular in depigmenting the skin.

Abstract: Disclosed is an alcoholic extract of aerial parts of Anthyllis vulneraria, method for obtaining same, a cosmetic or dermatological composition containing same, as well as the cosmetic and dermatological uses thereof, in particular in depigmenting the skin.

Abstract: The disclosure relates to the identification and the use of compounds which regulate the expression of at least one Sestrin gene, for preventing and/or attenuating skin ageing, and/or for hydrating the skin and/or for regulating skin pigmentation. The method includes the following steps: a. bringing at least one test compound in contact with a sample of human keratinocytes or melanocytes; b. measuring the expression of at least one Sestrin gene chosen from SESN3, SESN2 and SESN1 in the keratinocytes or melanocytes; c. selecting the compounds for which an activation of at least 1.6 fold of the expression of at least one of the genes is measured in the keratinocytes treated in a. compared with the untreated keratinocytes, or for which a significant modulation of the expression of at least one of the genes is measured in the melanocytes treated in a. compared with the untreated melanocytes.

Abstract: Disclosed are methods for screening for candidate compounds for hydrating the skin. The compounds selected according to the methods disclosed therein stimulate the intra-cellular amount and/or activity of TonEBP in keratinocytes. Preferably, the selected compounds induce a stimulation of at least 20%, preferably at least 50%, preferably at least 100% of the activity and/or intra-cellular amount of TonEBP.

Abstract: The disclosure relates to the identification and the use of compounds which regulate the expression of at least one Sestrin gene, for preventing and/or attenuating skin ageing, and/or for hydrating the skin and/or for regulating skin pigmentation. The method includes the following steps: a. bringing at least one test compound in contact with a sample of human keratinocytes or melanocytes; b. measuring the expression of at least one Sestrin gene chosen from SESN3, SESN2 and SESN1 in the keratinocytes or melanocytes; c. selecting the compounds for which an activation of at least 1.6 fold of the expression of at least one of the genes is measured in the keratinocytes treated in a. compared with the untreated keratinocytes, or for which a significant modulation of the expression of at least one of the genes is measured in the melanocytes treated in a. compared with the untreated melanocytes.