Patents by Inventor Frances Arnold

Frances Arnold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL SIGNAL PEPTIDES GENERATED BY ATTENTION-BASED NEURAL NETWORKS
    Publication number: 20230234989
    Abstract: The disclosure provides for artificial signal peptides generated by systems and methods utilizing deep learning.
    Type: Application
    Filed: June 4, 2021
    Publication date: July 27, 2023
    Inventors: Michael LISZKA, Alina BATZILLA, Zachary WU, Frances ARNOLD
  • ALKANE OXIDATION BY MODIFIED HYDROXYLASES
    Publication number: 20220112524
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Application
    Filed: December 23, 2021
    Publication date: April 14, 2022
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M.Y. Chen
  • Alkane oxidation by modified hydroxylases
    Patent number: 11214817
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: January 4, 2022
    Assignee: California Institute of Technology
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M. Y. Chen
  • ALKANE OXIDATION BY MODIFIED HYDROXYLASES
    Publication number: 20200399662
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Application
    Filed: May 11, 2020
    Publication date: December 24, 2020
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M.Y. Chen
  • Alkane oxidation by modified hydroxylases
    Patent number: 10648006
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: May 12, 2020
    Assignee: California Institute of Technology
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M. Y. Chen
  • ALKANE OXIDATION BY MODIFIED HYDROXYLASES
    Publication number: 20180273983
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Application
    Filed: March 30, 2018
    Publication date: September 27, 2018
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M.Y. Chen
  • Alkane oxidation by modified hydroxylases
    Patent number: 9963720
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: May 8, 2018
    Assignee: California Institute of Technology
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M. Y. Chen
  • ALKANE OXIDATION BY MODIFIED HYDROXYLASES
    Publication number: 20170183689
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Application
    Filed: August 1, 2016
    Publication date: June 29, 2017
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M.Y. Chen
  • Alkane oxidation by modified hydroxylases
    Patent number: 9404096
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: August 2, 2016
    Assignee: California Institute of Technology
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M. Y. Chen
  • ALKANE OXIDATION BY MODIFIED HYDROXYLASES
    Publication number: 20160024482
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Application
    Filed: June 30, 2015
    Publication date: January 28, 2016
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M.Y. Chen
  • Alkane oxidation by modified hydroxylases
    Patent number: 9074178
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: July 7, 2015
    Assignee: The California Institute of Technology
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M. Y. Chen
  • Modified alcohol dehydrogenases for the production of fuels and chemicals
    Patent number: 9012189
    Abstract: The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived by-products. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: April 21, 2015
    Assignees: Gevo, Inc., The California Institute of Technology
    Inventors: Sabine Bastian, Frances Arnold, Peter Meinhold
  • ALKANE OXIDATION BY MODIFIED HYDROXYLASES
    Publication number: 20150004668
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Application
    Filed: May 5, 2014
    Publication date: January 1, 2015
    Applicant: The California Institute of Technology
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M.Y. Chen
  • Alkane oxidation by modified hydroxylases
    Patent number: 8715988
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Grant
    Filed: April 6, 2007
    Date of Patent: May 6, 2014
    Assignee: California Institute of Technology
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M. Y. Chen
  • MODIFIED ALCOHOL DEHYDROGENASES FOR THE PRODUCTION OF FUELS AND CHEMICALS
    Publication number: 20140017748
    Abstract: The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived by-products. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
    Type: Application
    Filed: March 27, 2012
    Publication date: January 16, 2014
    Applicants: GEVO, INC., The California Institute of Technology
    Inventors: Sabine BASTIAN, Frances Arnold, Peter Meinhold
  • ENGINEERED MICROOGRANISMS CAPABLE OF PRODUCING TARGET COMPOUNDS UNDER ANAEROBIC CONDITIONS
    Publication number: 20120190089
    Abstract: The present invention is generally provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The invention further provides ketol-acid reductoisomerase enzymes which have been mutated or modified to increase their NADH-dependent activity or to switch the cofactor preference from NADPH to NADH and are expressed in the modified microorganisms. In addition, the invention provides isobutyraldehyde dehydrogenase enzymes expressed in modified microorganisms. Also provided are methods of producing beneficial metabolites under aerobic and anaerobic conditions by contacting a suitable substrate with the modified microorganisms of the present invention.
    Type: Application
    Filed: November 23, 2011
    Publication date: July 26, 2012
    Applicants: California Institute of Technology, Gevo, Inc.
    Inventors: Thomas Buelter, Peter Meinhold, Reid M. Renny Feldman, Andrew C. Hawkins, Sabine Bastian, Frances Arnold, Jun Urano
  • ENGINEERED MICROORGANISMS CAPABLE OF PRODUCING TARGET COMPOUNDS UNDER ANAEROBIC CONDITIONS
    Publication number: 20120058532
    Abstract: The present invention is generally provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The invention further provides ketol-acid reductoisomerase enzymes which have been mutated or modified to increase their NADH-dependent activity or to switch the cofactor preference from NADPH to NADH and are expressed in the modified microorganisms. In addition, the invention provides isobutyraldehyde dehydrogenase enzymes expressed in modified microorganisms. Also provided are methods of producing beneficial metabolites under aerobic and anaerobic conditions by contacting a suitable substrate with the modified microorganisms of the present invention.
    Type: Application
    Filed: October 11, 2011
    Publication date: March 8, 2012
    Applicants: California Institute of Technology, Gevo, Inc.
    Inventors: Thomas Buelter, Peter Meinhold, Reid M. Renny Feldman, Andrew Hawkins, Sabine Bastian, Frances Arnold, Jun Urano
  • ENGINEERED MICROORGANISMS CAPABLE OF PRODUCING TARGET COMPOUNDS UNDER ANAEROBIC CONDITIONS
    Publication number: 20120028324
    Abstract: The present invention is generlly provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The invention further provides ketol-acid reductoisomerase enzymes which have been mutated or modified to increase their NADH-dependent activity or to switch the cofactor preference from NADPH to NADH and are expressed in the modified microorganisms. In addition, the invention provides isobutyraldehyde dehydrogenase enzymes expressed in modified microorganisms. Also provided are methods of producing beneficial metabolites under aerobic and anaerobic conditions by contacting a suitable substrate with the modified microorganisms of the present invention.
    Type: Application
    Filed: October 10, 2011
    Publication date: February 2, 2012
    Applicants: California Institute of Technology, Gevo, Inc.
    Inventors: Thomas Buelter, Peter Meinhold, Reid M. Renny Feldman, Andrew Hawkins, Sabine Bastian, Frances Arnold, Jun Urano
  • Engineered microorganisms capable of producing target compounds under anaerobic conditions
    Patent number: 8097440
    Abstract: The present invention is generally provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The invention further provides ketol-acid reductoisomerase enzymes which have been mutated or modified to increase their NADH-dependent activity or to switch the cofactor preference from NADPH to NADH and are expressed in the modified microorganisms. In addition, the invention provides isobutyraldehyde dehydrogenase enzymes expressed in modified microorganisms. Also provided are methods of producing beneficial metabolites under aerobic and anaerobic conditions by contacting a suitable substrate with the modified microorganisms of the present invention.
    Type: Grant
    Filed: October 10, 2011
    Date of Patent: January 17, 2012
    Assignees: Gevo, Inc., California Institute of Technology
    Inventors: Thomas Buelter, Peter Meinhold, Reid M. Renny Feldman, Andrew C. Hawkins, Jun Urano, Sabine Bastian, Frances Arnold
  • Modified alcohol dehydrogenases for the production of fuels and chemicals
    Publication number: 20110201072
    Abstract: The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived by-products. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
    Type: Application
    Filed: February 11, 2011
    Publication date: August 18, 2011
    Applicant: GEVO, INC.
    Inventors: Sabine Bastian, Frances Arnold, Peter Meinhold