Patents by Inventor Frances C. Nelson
Frances C. Nelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20020188132Abstract: Compounds of the formula: 1Type: ApplicationFiled: December 4, 2000Publication date: December 12, 2002Inventors: Jeremy I. Levin, James M. Chen, Frances C. Nelson
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Patent number: 6200996Abstract: Compounds of the formula: are useful in treating disease conditions mediated by TNF-&agr; such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.Type: GrantFiled: January 27, 2000Date of Patent: March 13, 2001Assignee: American Cyanamid CompanyInventors: Jeremy I. Levin, James M. Chen, Frances C. Nelson
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Patent number: 6057340Abstract: This invention provides compounds of Formula 1 having the structure ##STR1## wherein: R.sub.1 is hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, benzyloxy, trifluoromethyl, chloro, bromo, or fluoro;a dashed line indicates an optional bond,X is NR.sub.4, or no atom;R.sub.2 is alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, cycloalkylalkyl wherein the cycloalkyl moiety is 3-8 carbon atoms and the alkyl moiety is 1-6 carbon atoms, aryl of 5-12 carbon atoms, or arylalkyl of 6-12 carbon atoms;R.sub.3 is aryl of 5-12 carbon atoms, arylalkyl of 6-12 carbon atoms, or heteroaryl of 5-12 atoms;R.sub.4 is hydrogen or alkyl of 1-6 carbon atoms;or a pharmaceutically acceptable salt thereof, which are useful in the treatment of psychosis (e.g. schizophrenia), anxiety, depression and related CNS disorders and other conditions such as the treatment of alcohol and drug withdrawal, sexual dysfunction and memory deficits associated with Alzheimer's disease and other dementias.Type: GrantFiled: February 3, 1999Date of Patent: May 2, 2000Assignee: American Home Products CorporationInventors: Michael G. Kelly, Lynne P. Greenblatt, Frances C. Nelson
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Patent number: 5559122Abstract: A compound of the structure ##STR1## wherein R and R.sup.1 are each, independently, ##STR2## or hydrogen; R.sup.2 and R.sup.3 are each, independently, alkyl, arylalkyl, or R.sup.2 and R.sup.3 may be taken together to form a cycloalkyl ring;R.sup.4 is a heterocyclic N-oxide radical, which may be optionally substituted;R.sup.5 is alkyl or arylalkyl;R.sup.6 and R.sup.7 are taken together to form a saturated N-alkyl-heterocyclic N-oxide, which may be optionally substituted;k=0-1,m=0-1;n=1-6;with the proviso that R and R.sup.1 are not both hydrogen, which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.Type: GrantFiled: May 24, 1995Date of Patent: September 24, 1996Assignee: American Home Products CorporationInventors: Frances C. Nelson, Guy A. Schiehser
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Patent number: 5521194Abstract: A compound of the structure ##STR1## wherein R and R.sup.1 are each independently, ##STR2## or hydrogen; R.sup.2 and R.sup.3 are each, independently, alkyl, arylalkyl, or R.sup.2 and R.sup.3 may be taken together to form a cycloalkyl ring;R.sup.4 is a heterocyclic N-oxide radical, which may be optionally substituted;R.sup.5 is alkyl or arylalkyl;R.sup.6 and R.sup.7 are taken together to form a saturated N-alkyl-heterocyclic N-oxide, which may be optionally substituted;k=0-1,m=0-1;n=1-6;with the proviso that R and R.sup.1 are not both hydrogen, which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.Type: GrantFiled: May 24, 1995Date of Patent: May 28, 1996Assignee: American Home Products CorporationInventors: Frances C. Nelson, Guy A. Schiehser
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Patent number: 5508285Abstract: A compound of the structure ##STR1## wherein R and R.sup.1 are each, independently, ##STR2## or hydrogen; R.sup.2 and R.sup.3 are each, independently, alkyl, arylalkyl , or R.sup.2 and R.sup.3 may be taken together to form a cycloalkyl ring;R.sup.4 is a heterocyclic N-oxide radical, which may be optionally substituted;R.sup.5 is alkyl or arylalkyl;R.sup.6 and R.sup.7 are taken together to form a saturated N-alkyl-heterocyclic N-oxide, which may be optionally substituted;k=0-1,m=0-1;n=1-6;with the proviso that R and R.sup.1 are not both hydrogen, which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.Type: GrantFiled: May 24, 1995Date of Patent: April 16, 1996Assignee: American Home Products CorporationInventors: Frances C. Nelson, Guy A. Schiehser
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Patent number: 5508290Abstract: A compound of the structure ##STR1## wherein R and R.sup.1 are each, independently, ##STR2## or hydrogen; R.sup.2 and R.sup.3 are each, independently, alkyl, arylalkyl , or R.sup.2 and R.sup.3 may be taken together to form a cycloalkyl ring;R.sup.4 is a heterocyclic N-oxide radical, which may be optionally substituted;R.sup.5 is alkyl or arylalkyl;R.sup.6 and R.sup.7 are taken together to form a saturated N-alkyl-heterocyclic N-oxide, which may be optionally substituted;k=0-1,m=0-1;n=1-6;with the proviso that R and R.sup.1 are not both hydrogen, which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.Type: GrantFiled: May 24, 1995Date of Patent: April 16, 1996Assignee: American Home Products CorporationInventors: Frances C. Nelson, Guy A. Schiehser
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Patent number: 5491231Abstract: A compound of the structure ##STR1## wherein R and R.sup.1 are each, independently, ##STR2## or hydrogen; R.sup.2 and R.sup.3 are each, independently, alkyl, arylalkyl , or R.sup.2 and R.sup.3 may be taken together to form a cycloalkyl ring;R.sup.4 is a heterocyclic N-oxide radical, which may be optionally substituted;R.sup.5 is alkyl or arylalkyl;R.sup.6 and R.sup.7 are taken together to form a saturated N-alkyl-heterocyclic N-oxide, which may be optionally substituted;k=0-1,m=0-1;n=1-6;with the proviso that R and R.sup.1 are not both hydrogen, which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.Type: GrantFiled: November 28, 1994Date of Patent: February 13, 1996Assignee: American Home Products CorporationInventors: Frances C. Nelson, Guy A. Schiehser
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Patent number: 5387680Abstract: This invention provides C-22 substituted rapamycin derivatives of the following formulas: ##STR1## and pharmaceutically acceptable salts thereof which are useful for inducing immunosuppression and treating transplantation rejection, host vs. graft disease, autoimmune diseases, diseases of inflammation, solid tumors, fungal infections, adult T-cell leukemia/lymphomas and hyperproliferative vascular disorders.Type: GrantFiled: August 10, 1993Date of Patent: February 7, 1995Assignee: American Home Products CorporationInventor: Frances C. Nelson
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Patent number: 5385908Abstract: A compound of the structure ##STR1## wherein R and R.sup.1 are each, independently, ##STR2## or hydrogen; R.sup.2 and R.sup.3 are each, independently, alkyl, arylalkyl, or R.sup.2 and R.sup.3 may be taken together to form a cycloalkyl ring;R.sup.4 is a heterocyclic radical which may be optionally substituted;R.sup.5 is alkyl or arylalkyl;R.sup.6 and R.sup.7 are taken together to form a saturated heterocyclic ring which may be optionally substituted;k=0-1,m=0-1;n=1-6;with the proviso that R and R.sup.1 are not both hydrogen, or a pharmaceutically acceptable salt thereof, which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.Type: GrantFiled: November 22, 1993Date of Patent: January 31, 1995Assignee: American Home Products CorporationInventors: Frances C. Nelson, Guy A. Schiehser
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Patent number: 5385909Abstract: A compound of the structure ##STR1## wherein R and R.sup.1 are each, independently, ##STR2## or hydrogen, R.sup.2 is a heterocyclic radical which may be optionally substituted;n=0-6;with the proviso that R and R.sup.1 are both not hydrogen, or a pharmaceutically acceptable salt thereof which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.Type: GrantFiled: November 22, 1993Date of Patent: January 31, 1995Assignee: American Home Products CorporationInventors: Frances C. Nelson, Guy A. Schiehser
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Patent number: 5302600Abstract: This invention provides a compound of formula I, ##STR1## and 27-substituted derivatives thereof which are useful as immunosuppressive, anti-inflammatory, antifungal, antitumor, and antiproliferative agents. The compound depicted by formula I is named 27-hydroxyrapamycin, and may also be referred to as 27-deoxo-27-hydroxyrapamycin.Type: GrantFiled: July 22, 1993Date of Patent: April 12, 1994Assignee: American Home Products CorporationInventor: Frances C. Nelson
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Patent number: 5256790Abstract: This invention provides a compound of formula I, ##STR1## and 27-substituted derivatives thereof which are useful as immunosuppressive, antiinflammatory, antifungal, antitumor, and antiproliferative agents. The compound depicted by formula I is named 27-hydroxyrapamycin, and may also be referred to as 27-deoxo-27-hydroxyrapamycin.Type: GrantFiled: January 27, 1993Date of Patent: October 26, 1993Assignee: American Home Products CorporationInventor: Frances C. Nelson