Patents by Inventor Frances Calderon

Frances Calderon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Growth matrices for stem cell propagation in vitro and in tissue regeneration
    Patent number: 10465165
    Abstract: The present invention provides a multifunctional 2-D and 3-D matrix for propagation of stem cells. In particular, a chitosan-based biomaterial scaffold is engineered to promote CNS regeneration from primitive neural precursors by stabilizing a recombinant protein, fibroblast growth factor to preserve the cardinal properties of stem cells. The matrix, is further modified by the addition of either the extracellular matrix protein fibronectin or the small peptide RGD or IKVAV. A method to manufacture an injectable multifunctional microsphere scaffold is also disclosed that is suitable as a vehicle for cell transplantation to repair traumatic brain injuries.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: November 5, 2019
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, NEW JERSEY INSTITUTE OF TECHNOLOGY
    Inventors: Cheul Cho, Steven Levison, Nolan Skop, Frances Calderon, Chirag Gandhi
  • GROWTH MATRICES FOR STEM CELL PROPAGATION IN VITRO AND IN TISSUE REGENERATION
    Publication number: 20150361395
    Abstract: The present invention provides a multifunctional 2-D and 3-D matrix for propagation of stem cells. In particular, a chitosan-based biomaterial scaffold is engineered to promote CNS regeneration from primitive neural precursors by stabilizing a recombinant protein, fibroblast growth factor to preserve the cardinal properties of stem cells. The matrix, is further modified by the addition of either the extracellular matrix protein fibronectin or the small peptide RGD or IKVAV. A method to manufacture an injectable multifunctional microsphere scaffold is also disclosed that is suitable as a vehicle for cell transplantation to repair traumatic brain injuries.
    Type: Application
    Filed: January 28, 2014
    Publication date: December 17, 2015
    Inventors: Steven Levison, Nolan Skop, Frances Calderon, Cheul Cho, Chirag Gandhi