Patents by Inventor Frances I. Smith

Frances I. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HSV/AAV hybrid amplicon vectors
    Patent number: 5965441
    Abstract: The present invention relates to a hybrid vector system which incorporates elements of herpesvirus and adeno-associated virus and which is capable of expressing a gene product in eukaryotic cells. The vector system of the present invention provides a means of packaging plasmid DNA into highly infectious virions which can efficiently and safely deliver large transgenes to both mitotic and postmitotic cells in a state which can be maintained for extended periods. The invention pertains to the use of this vector system in introducing and expressing gene sequences in mitotic and postmitotic cells.
    Type: Grant
    Filed: November 12, 1997
    Date of Patent: October 12, 1999
    Assignee: The General Hospital Coporation
    Inventors: Xandra O. Breakefield, David R. Jacoby, Frances I. Smith