Patents by Inventor Frances Kay Huebner

Frances Kay Huebner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FHIT proteins and nucleic acids and methods based thereon
    Patent number: 7220834
    Abstract: The present invention relates to nucleotide sequences of FHIT genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof, and antibodies thereto. The FHIT gene sequence is mutated in diseases involving cell overproliferation, particularly malignancies of the digestive tract. The present invention further relates to the use of FHIT genes and their encoded proteins as diagnostic and therapeutic reagents for the detection and treatment of disease states associated with cell overproliferation.
    Type: Grant
    Filed: August 6, 2004
    Date of Patent: May 22, 2007
    Assignee: Thomas Jefferson University
    Inventors: Carlo M. Croce, Frances Kay Huebner
  • Muir-torre-like syndrome in Fhit deficient mice
    Patent number: 6924414
    Abstract: The invention provides nonhuman transgenic animals with a disrupted FHIT gene. The invention further provides transgenic mice in which one or both Fhit alleles have been inactivated. Preferably, the Fhit-deficient mice develop multiple tumors of both visceral and sebaceous origin, similar to those of Muir-Torre familial cancer syndrome. The present invention further relates to the generation of these transgenic mice and their use as model systems to study the effects of carcinogenic agents in promoting clonal expansion of neoplastic cells in cancers, preferably gastrointestinal cancers of which Muir-Torre syndrome is a subset. The invention further relates to testing therapeutic agents for their efficacy in the prevention and treatment of cancer, preferably gastrointestinal cancer.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: August 2, 2005
    Assignee: Thomas Jefferson University
    Inventors: Carlo M. Croce, Frances Kay Huebner
  • FHIT proteins and nucleic acids and methods based thereon
    Publication number: 20040265316
    Abstract: The present invention relates to nucleotide sequences of FHIT genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof, and antibodies thereto. The FHIT gene sequence is mutated in diseases involving cell overproliferation, particularly malignancies of the digestive tract. The present invention further relates to the use of FHIT genes and their encoded proteins as diagnostic and therapeutic reagents for the detection and treatment of disease states associated with cell overproliferation.
    Type: Application
    Filed: July 13, 2004
    Publication date: December 30, 2004
    Applicant: Thomas Jefferson University
    Inventors: Carlo M. Croce, Frances Kay Huebner
  • FHIT proteins and nucleic acids and methods based thereon
    Patent number: 6774217
    Abstract: The present invention relates to nucleotide sequences of FHIT genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof, and antibodies thereto. The FHIT gene sequence is mutated in diseases involving cell overproliferation, particularly malignancies of the digestive tract. The present invention further relates to the use of FHIT genes and their encoded proteins as diagnostic and therapeutic reagents for the detection and treatment of disease states associated with cell overproliferation.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: August 10, 2004
    Assignee: Thomas Jefferson University
    Inventors: Carlo M. Croce, Frances Kay Huebner
  • Muir-torre-like syndrome in Fhit deficient mice
    Publication number: 20020116726
    Abstract: The invention provides nonhuman transgenic animals with a disrupted FHIT gene. The invention further provides transgenic mice in which one or both Fhit alleles have been inactivated. Preferably, the Fhit-deficient mice develop multiple tumors of both visceral and sebaceous origin, similar to those of Muir-Torre familial cancer syndrome. The present invention further relates to the generation of these transgenic mice and their use as model systems to study the effects of carcinogenic agents in promoting clonal expansion of neoplastic cells in cancers, preferably gastrointestinal cancers of which Muir-Torre syndrome is a subset. The invention further relates to testing therapeutic agents for their efficacy in the prevention and treatment of cancer, preferably gastrointestinal cancer.
    Type: Application
    Filed: April 11, 2001
    Publication date: August 22, 2002
    Inventors: Carlo M. Croce, Frances Kay Huebner
  • Fragile histidine triad (FHIT) nucleic acids and methods of producing FHIT proteins
    Patent number: 6242212
    Abstract: The present invention relates to nucleotide sequences of FHIT genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof, and antibodies thereto. The FHIT gene sequence is mutated in diseases involving cell overproliferation, particularly malignancies of the digestive tract. The present invention further relates to compositions of FHIT nucleic acids and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: February 22, 1996
    Date of Patent: June 5, 2001
    Assignee: Thomas Jefferson University
    Inventors: Carlo M. Croce, Frances Kay Huebner
  • FHIT proteins and nucleic acids and methods based thereon
    Patent number: 5928884
    Abstract: The present invention relates to nucleotide sequences of FHIT genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof, and antibodies thereto. The FHIT gene sequence is mutated in diseases involving cell overproliferation, particularly malignancies of the digestive tract. The present invention further relates to the use of FHIT genes and their encoded proteins as diagnostic and therapeutic reagents for the detection and treatment of disease states associated with cell overproliferation.
    Type: Grant
    Filed: February 9, 1996
    Date of Patent: July 27, 1999
    Inventors: Carlo M. Croce, Frances Kay Huebner