Patents by Inventor Frances Ligler

Frances Ligler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070092901
    Abstract: An apparatus having within or as part of a housing; a sample port; a microarray port; a lysis module; a purification module for containing a solid phase for binding of oligonucleotides; a thermocycling module for containing a polymerase chain reaction; a fragmentation module; and a microarray module for holding a microarray and a liquid in contact with the microarray. The apparatus is configured to be coupled to a device for: pumping a liquid through, in order, the lysis, purification, thermocycling, fragmentation, and microarray modules; sonicating any contents of the lysis module; thermocycling the thermocycling module to perform the polymerase chain reaction; heating the fragmentation module to fragment any oligonucleotides contained therein; circulating a fluid over the surface of the microarray; and performing one or more washing or staining steps on the microarray.
    Type: Application
    Filed: November 14, 2006
    Publication date: April 26, 2007
    Applicant: The Government of the US, as represented by the Secretary of the Navy
    Inventors: Frances Ligler, David Stenger, Jeff Erickson, Marie Archer
  • Publication number: 20060281074
    Abstract: A method of biochemical identification by: providing a plurality of capture species bound to one or more substrates and suspected of having one or more biological targets affinity bound to at least one capture species; detecting which capture species contain bound biological targets to generate a binding pattern; and identifying the biological target based on the binding pattern. The capture species are independently selected from the group consisting of antimicrobial peptides, cytotoxic peptides, antibiotics, and combinations thereof. A device having the capture species bound to the substrates. At least two of the capture species are capable of multi-specific binding to one or more biological targets and may have overlapping but not identical affinity properties.
    Type: Application
    Filed: February 6, 2006
    Publication date: December 14, 2006
    Applicant: The Government of the US, as represented by the Secretary of the Navy
    Inventors: Nadezhda Kulagina, Chris Taitt, George Anderson, Frances Ligler