Patents by Inventor Frances M. Platt
Frances M. Platt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9089515Abstract: Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.Type: GrantFiled: March 7, 2011Date of Patent: July 28, 2015Assignees: Thomas Jefferson University, The Chancellor, Masters and Scholars of the University of Oxford, United Therapeutics CorporationInventors: Nicole Zitzmann, Terry D. Butters, Frances M. Platt, Gary S. Jacob, Donald H. Picker, Sandra Carrouee, George W. J. Fleet, Raymond A. Dwek, David Durantel, Anand Mehta, Timothy M. Block
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Publication number: 20110184019Abstract: Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.Type: ApplicationFiled: March 7, 2011Publication date: July 28, 2011Inventors: Nicole Zitzmann, Terry D. Butters, Frances M. Platt, Gary S. Jacob, Donald H. Picker, Sandra Carrouee, George W. J. Fleet, Raymond A. Dwek, David Durantel, Anand Mehta, Timothy M. Block
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Patent number: 7816560Abstract: Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.Type: GrantFiled: August 10, 2000Date of Patent: October 19, 2010Assignees: Thomas Jefferson University, The Chancellor, Masters and Scholars of the University of Oxford, United Therapeutics CorporationInventors: Nicole Zitzmann, Terry D. Butters, Frances M. Platt, Gary S. Jacob, Donald H. Picker, Sandra Carrouee, George W. J. Fleet, Raymond A. Dwek, David Durantel, Anand Mehta, Timothy M. Block
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Publication number: 20100137365Abstract: Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.Type: ApplicationFiled: January 28, 2010Publication date: June 3, 2010Inventors: Nicole Zitzmann, Terry D. Butters, Frances M. Platt, Gary S. Jacob, Donald H. Picker, Sandra Carrouee, George W.J. Fleet, Raymond A. Dwek, David Durantel, Anand Mehta, Timothy M. Block
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Publication number: 20040019082Abstract: The present invention provides a method by which to reversibly render male mammals infertile. Thus, the disclosed N-substituted imino compounds, and pharmaceutical compositions thereof, completely impair the fertility of male mammals, but exhibit no effect on that of female mammals, and are thus useful as male contraceptives.Type: ApplicationFiled: March 13, 2003Publication date: January 29, 2004Applicant: United Therapeutics CorporationInventors: Aarnoud C. van der Spoel, Mylvaganam Jeyakumar, Terry D. Butters, Raymond A. Dwek, Frances M. Platt
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Patent number: 6660749Abstract: Methods for treating lipid storage diseases using compounds that inhibit glucosyltransferase enzymes are disclosed herein. The invention relates to the treatment of lipid storage disease with compounds that inhibit glucosyltransferase activity in the affected cells. It relates particularly to the use of 1,5-dideoxy-1,5-imino-D-glucitol and derivatives thereof.Type: GrantFiled: September 17, 2002Date of Patent: December 9, 2003Assignee: Chancellor, Masters and Scholars of the University of OxfordInventors: Terry D. Butters, Frances M. Platt, Raymond A. Dwek
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Patent number: 6610703Abstract: A novel method is disclosed for the treatment of a patient affected with Gaucher's disease or other such glycolipid storage diseases. The method comprises administering to said patient a therapeutically effective amount of a long-chain N-alkyl derivative of deoxynojirimycin to alleviate or inhibit the glycolipid storage disease. The long-chain alkyl group has from nine to about 20 carbon atoms and preferably is nonyl or decyl.Type: GrantFiled: December 2, 1999Date of Patent: August 26, 2003Assignees: G.D. Searle & Co., Oxford UniversityInventors: Gary S. Jacob, Frances M. Platt, Terry D. Butters, Raymond A. Dwek
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Publication number: 20030130317Abstract: Methods for treating lipid storage diseases using compounds that inhibit glucosyltransferase enzymes are disclosed herein. The invention relates to the treatment of lipid storage disease with compounds that inhibit glucosyltransferase activity in the affected cells. It relates particularly to the use of 1,5-dideoxy-1,5-imino-D-glucitol and derivatives thereof.Type: ApplicationFiled: September 17, 2002Publication date: July 10, 2003Inventors: Terry D. Butters, Frances M. Platt, Raymond A. Dwek
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Patent number: 6465488Abstract: Methods for treating lipid storage diseases using compounds that inhibit glucosyltransferase enzymes are disclosed herein. The invention relates to the treatment of lipid storage disease with compounds that inhibit glucosyltransferase activity in the affected cells. It relates particularly to the use of 1,5-dideoxy-1,5-imino-D-glucitol and derivatives thereof.Type: GrantFiled: April 21, 2000Date of Patent: October 15, 2002Assignee: Chancellor, Masters & Scholars of the University of OxfordInventors: Terry D. Butters, Frances M. Platt, Raymond A. Dwek
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Patent number: 6291657Abstract: Novel N-alkyl derivatives of deoxygalactonojirimycin are provided in which said alkyl contains from 3-6 carbon atoms. These novel compounds are useful for selectively inhibiting glycolipid synthesis.Type: GrantFiled: August 5, 1993Date of Patent: September 18, 2001Assignee: Monsanto CompanyInventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
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Patent number: 6069235Abstract: A method is disclosed for modifying the carbohydrate moiety on glycoproteins to facilitate the structural and functional analysis of said glycoproteins such as by NMR spectroscopic analysis and crystallography which comprises treating glycoprotein-secreting mammalian cells having low endomannosidase activity under cell culture maintenance conditions with a glucosidase I inhibitor, and after secretion and purification, subsequent treatment of the active glycoprotein with endoglycosidase H to thereby provide a glycoprotein with a single GlcNAc residue at each glycosylation sequon. The preferred mammalian cells are CHO cells and the preferred glucosidase I inhibitor is N-butyl deoxynojirimycin.Type: GrantFiled: February 23, 1994Date of Patent: May 30, 2000Assignee: Monsanto CompanyInventors: Simon J. Davis, Terence D. Butters, Gunilla B. Karlsson, Frances M. Platt, Martin L. Bryant, Raymond A. Dwek
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Patent number: 5801185Abstract: A method is disclosed for the treatment of Tay-Sachs disease comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.Type: GrantFiled: January 13, 1997Date of Patent: September 1, 1998Assignee: Monsanto CompanyInventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
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Patent number: 5798366Abstract: A method is disclosed for the in vivo treatment of patients having a lysosomal storage disease with a significant central nervous system (CNS) involvement. Said method comprises administration to said patient a small but storage-inhibitory effective amount of an N-alkyl derivative of a 1,5-iminosugar in which said alkyl group contains from about 2 to about 8 carbon atoms and said 1,5-iminosugar is 1,5-dideoxy-1,5-imino-D-glucitol, or 1,5-dideoxy-1,5-imino-D-galactitol, or an O-acylated pro-drug of said 1,5-iminosugar. In an illustrative example, CNS storage of GM2 ganglioside is inhibited in Tay-Sachs mice by administration of 1,5-(butylimino)-1,5-dideoxy-D-glucitol.Type: GrantFiled: January 13, 1997Date of Patent: August 25, 1998Assignee: Monsanto CompanyInventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
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Patent number: 5786368Abstract: Novel N-alkyl derivatives of deoxygalactonojirimycin are provided in which said alkyl contains from 3-6 carbon atoms. These novel compounds are useful for selectively inhibiting glycolipid synthesis.Type: GrantFiled: January 17, 1996Date of Patent: July 28, 1998Assignee: Monsanto CompanyInventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
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Patent number: 5786369Abstract: A method is disclosed for inhibiting the surface expression of glycolipid receptors for bacteria by subjecting bacteria cells to an inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.Type: GrantFiled: May 20, 1996Date of Patent: July 28, 1998Assignee: Monsanto CompanyInventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
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Patent number: 5656641Abstract: A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.Type: GrantFiled: February 24, 1995Date of Patent: August 12, 1997Assignee: Monsanto CompanyInventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
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Patent number: 5580884Abstract: Novel N-alkyl derivatives of deoxygalactonojirimycin are provided in which said alkyl contains from 3-6 carbon atoms. These novel compounds are useful for selectively inhibiting glycolipid synthesis.Type: GrantFiled: March 1, 1995Date of Patent: December 3, 1996Assignee: Monsanto CompanyInventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
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Patent number: 5525616Abstract: A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.Type: GrantFiled: May 12, 1995Date of Patent: June 11, 1996Assignee: Monsanto CompanyInventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
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Patent number: 5472969Abstract: A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.Type: GrantFiled: October 12, 1994Date of Patent: December 5, 1995Assignee: Monsanto CompanyInventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
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Patent number: 5399567Abstract: This invention discloses a method of treating cholera infection in a human by administering an effective amount of 1,5-dideoxy-1,5-imino-D-glucitol or a derivative thereof.Type: GrantFiled: May 13, 1993Date of Patent: March 21, 1995Assignee: Monsanto CompanyInventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters