Patents by Inventor Frances Mary Platt

Frances Mary Platt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF MYCOBACTERIAL INFECTION
    Publication number: 20180125796
    Abstract: The invention provides a combination comprising a SERCA antagonist and an inhibitor of glycosphingolipid biosynthesis, for use in the treatment of an infection by a pathogenic mycobacterium. The combination may for instance be used to treat tuberculosis.
    Type: Application
    Filed: January 7, 2016
    Publication date: May 10, 2018
    Inventors: Frances Mary Platt, Nick Platt, Paul Fineran, Edith Sim, Emyr Lloyd-Evans, Nathan Lack
  • Substrate reduction therapy
    Patent number: 9428541
    Abstract: The present invention provides a compound which is an inhibitor of sphingolipid biosynthesis for use in the treatment of a disease which has a secondary Niemann-Pick type C disease like cellular phenotype.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: August 30, 2016
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Chancellor, Masters, and Scholars of the University of Oxford
    Inventors: Frances Mary Platt, Emyr Lloyd-Evans, Forbes Dennison Porter
  • Pharmaceutically active piperidine derivatives
    Patent number: 9199935
    Abstract: Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: December 1, 2015
    Assignee: Acetelion Pharmaceuticals Ltd.
    Inventors: Terence D. Butters, Raymond A. Dwek, George W. J. Fleet, Michael Glen Orchard, Frances Mary Platt
  • PHARMACEUTICALLY ACTIVE PIPERIDINE DERIVATIVES
    Publication number: 20140303208
    Abstract: Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.
    Type: Application
    Filed: April 7, 2014
    Publication date: October 9, 2014
    Applicant: Actelion Pharmaceuticals Ltd.
    Inventors: Terence D. BUTTERS, Raymond A. DWEK, George W. J. FLEET, Michael Glen ORCHARD, Frances Mary PLATT
  • Pharmaceutically active piperidine derivatives
    Patent number: 8729099
    Abstract: Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.
    Type: Grant
    Filed: August 3, 2005
    Date of Patent: May 20, 2014
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Terence D. Butters, Raymond A. Dwek, George W. J. Fleet, Michael Glen Orchard, Frances Mary Platt
  • SUBSTRATE REDUCTION THERAPY
    Publication number: 20140080769
    Abstract: The present invention provides a compound which is an inhibitor of sphingolipid biosynthesis for use in the treatment of a disease which has a secondary Niemann-Pick type C disease like cellular phenotype.
    Type: Application
    Filed: September 13, 2013
    Publication date: March 20, 2014
    Applicants: The Chancellor, Masters and Scholars of the University of Oxford, The Government of the United States of America, as represented by the Secretary, Department of Healt
    Inventors: Frances Mary Platt, Emyr Lloyd-Evans, Forbes Dennison Porter
  • Substrate reduction therapy
    Patent number: 8557844
    Abstract: The present invention provides a compound which is an inhibitor of sphingolipid biosynthesis for use in the treatment of a disease which has a secondary Niemann-Pick type C disease like cellular phenotype.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: October 15, 2013
    Assignees: The Chancellor, Masters and Scholars of the University of Oxford, The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Frances Mary Platt, Emyr Lloyd-Evans, Forbes Dennison Porter
  • EPITOPE REDUCTION THERAPY
    Publication number: 20100022620
    Abstract: The present invention provides the use of an inhibitor of glycolipid biosynthesis in the manufacture of a medicament for the treatment of a glycolipid-mediated autoimmune disease.
    Type: Application
    Filed: July 27, 2007
    Publication date: January 28, 2010
    Inventors: Matthew David Max Crispin, Christopher Scanlan, Frances Mary Platt, Hugh John Willison
  • Therapeutic compositions and methods of treating glycolipid storage related disorders
    Patent number: 7348000
    Abstract: A method for treating a glycolipid storage-related disorder, comprising administering a therapeutically effective amount of an inhibitor of glycolipid synthesis in combination with an agent capable of increasing the rate of glycolipid degradation or in combination with bone marrow transplantation. Inhibitors of glycolipid synthesis include N-butyldeoxynojirimycin (NB-DNJ), N-butyldeoxygalactonojirimycin (NB-DGJ) or N-nonyldeoxynojirimycin (NN-DNJ). Glycolipid storage-related disorders include Gaucher disease, Sandhoff's disease, Fabry's disease, Tay-Sach's disease, Niemann-Pick C storage disease, GM1 gangliosidosis, genetic disorders in which neuronal glycolipid accumulation contributes to disease pathology.
    Type: Grant
    Filed: January 15, 2004
    Date of Patent: March 25, 2008
    Assignee: Actelion Pharmaceuticals Ltd
    Inventors: Raymond A. Dwek, Terence D. Butters, Mylvaganam Jeyakumar, Frances Mary Platt, David Priestman
  • Pharmaceutically active piperidine derivatives
    Publication number: 20040097551
    Abstract: Compounds of formula (I): 1
    Type: Application
    Filed: July 11, 2003
    Publication date: May 20, 2004
    Inventors: Terence D. Butters, Raymond A. Dwek, George WJ Fleet, Michael Glen Orchard, Frances Mary Platt
  • Use of glucosylceramide synthesis inhibitors in brain cancertherapy
    Publication number: 20030069200
    Abstract: Treatments for brain cancer are provided, based on administration of inhibitors of glycophospholipids synthesis.
    Type: Application
    Filed: September 13, 2002
    Publication date: April 10, 2003
    Inventors: Frances Mary Platt, Thomas Neil Seyfried, Paul David Smith