Patents by Inventor Frances S. Ligler
Frances S. Ligler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230414527Abstract: Disclosed herein are low density particles comprising polymerized fibrin that are micrometer or nanometer sized in diameter. The particles can further include at least one therapeutic agent. The particles may be used to treat wounds, by administration directly or systemically to the site of the wound. Exemplary wounds that may be treated with the fibrin particles include a trauma wound, a surgical wound, a burn wound, or an ulcer wound. Also disclosed herein are methods for preparing the particles using a shearing process.Type: ApplicationFiled: September 7, 2023Publication date: December 28, 2023Inventors: Ismaeel MUHAMED, Ashley C. BROWN, Frances S. LIGLER
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Patent number: 11786477Abstract: Disclosed herein are low density particles comprising polymerized fibrin that are micrometer or nanometer sized in diameter. The particles can further include at least one therapeutic agent. The particles may be used to treat wounds, by administration directly or systemically to the site of the wound. Exemplary wounds that may be treated with the fibrin particles include a trauma wound, a surgical wound, a burn wound, or an ulcer wound. Also disclosed herein are methods for preparing the particles using a shearing process.Type: GrantFiled: December 3, 2018Date of Patent: October 17, 2023Assignee: North Carolina State UniversityInventors: Ismaeel Muhamed, Ashley C. Brown, Frances S. Ligler
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Publication number: 20210169813Abstract: Disclosed herein are low density particles comprising polymerized fibrin that are micrometer or nanometer sized in diameter. The particles can further include at least one therapeutic agent. The particles may be used to treat wounds, by administration directly or systemically to the site of the wound. Exemplary wounds that may be treated with the fibrin particles include a trauma wound, a surgical wound, a burn wound, or an ulcer wound. Also disclosed herein are methods for preparing the particles using a shearing process.Type: ApplicationFiled: December 3, 2018Publication date: June 10, 2021Inventors: Ismaeel MUHAMED, Ashley C. BROWN, Frances S. LIGLER
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Patent number: 10208289Abstract: A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.Type: GrantFiled: July 1, 2015Date of Patent: February 19, 2019Assignee: The United States of America, as represented by the Secretary of the NavyInventors: André A. Adams, Michael Daniele, Frances S. Ligler
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Patent number: 10099417Abstract: A sheath flow system having a channel with at least one fluid transporting structure located in the top and bottom surfaces situated so as to transport the sheath fluid laterally across the channel to provide sheath fluid fully surrounding the core solution. At the point of introduction into the channel, the sheath fluid and core solutions flow side by side within the channel or the core solution may be bounded on either side by the sheath fluid. The system is functional over a broad channel size range and with liquids of high or low viscosity. The design can be readily incorporated into microfluidic chips without the need for special manufacturing protocols. Uses include extruding materials and/or fabricating structures.Type: GrantFiled: August 12, 2015Date of Patent: October 16, 2018Assignee: The United States of America, as represented by the Secretary of the NavyInventors: David R. Mott, Frances S. Ligler, Stephanie Fertig, Aron Bobrowski
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Patent number: 9926534Abstract: A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.Type: GrantFiled: July 1, 2015Date of Patent: March 27, 2018Assignee: The United States of America, as represented by the Secretary of the NavyInventors: André A. Adams, Michael Daniele, Frances S. Ligler
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Patent number: 9649803Abstract: A sheath flow system having a channel with at least one fluid transporting structure located in the top and bottom surfaces situated so as to transport the sheath fluid laterally across the channel to provide sheath fluid fully surrounding the core solution. At the point of introduction into the channel, the sheath fluid and core solutions flow side by side within the channel or the core solution may be bounded on either side by the sheath fluid. The system is functional over a broad channel size range and with liquids of high or low viscosity. The design can be readily incorporated into microfluidic chips without the need for special manufacturing protocols. Uses include extruding materials and/or fabricating structures.Type: GrantFiled: May 29, 2015Date of Patent: May 16, 2017Assignee: The United States of America, as represented by the Secretary of the NavyInventors: David R. Mott, Peter B. Howell, Jr., Frances S. Ligler, Stephanie Fertig, Aron Bobrowski
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Patent number: 9573311Abstract: A sheath flow system having a channel with first and second fluid transporting structures located on opposing surfaces facing one another across the channel in the top and bottom surfaces of the channel situated so as to transport the sheath fluid laterally across the channel to provide sheath fluid fully surrounding the core solution. At the point of introduction into the channel, the sheath fluid and core solutions flow side by side within the channel or the core solution may be bounded on either side by the sheath fluid. The system is functional over a broad channel size range and with liquids of high or low viscosity. The design can be readily incorporated into microfluidic chips without the need for special manufacturing protocols.Type: GrantFiled: December 27, 2012Date of Patent: February 21, 2017Assignee: The United States of America, as represented by the Secretary of the NavyInventors: David R. Mott, Peter B. Howell, Jr., Frances S. Ligler, Stephanie Fertig, Aron Bobrowski
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Patent number: 9527050Abstract: A magnetic bead trap-and-mixer includes a channel having openings at opposing ends, and a rotor adjacent to the channel and comprising a permanent magnet, wherein the rotor is adapted to apply a magnetic field to the channel of sufficient strength to direct the movement of magnetic beads therein. In aspects, the channel is straight and/or has narrowed end. In further aspects, the rotor generates in the channel areas of areas of strong magnetic fields alternating with areas of very weak magnetic fields and the strong magnetic fields extend entirely across the channel.Type: GrantFiled: January 28, 2011Date of Patent: December 27, 2016Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Peter B Howell, Jr., Richard Eitel, Joel P Golden, Frances S Ligler
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Publication number: 20160130543Abstract: A perfusable, microtube-based flow system for microdevice models of human tissues and organs includes a microfluidic chip with a network of microtubes passing through at least one common chamber space suitable to hold cells of an appropriate organ and/or a biocompatible support matrix. The microtube model network can be used to create model tissues and organs for study and research.Type: ApplicationFiled: November 10, 2015Publication date: May 12, 2016Inventors: Michael A. Daniele, Steven A. Roberts, Frances S. Ligler, André A. Adams
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Publication number: 20150343691Abstract: A sheath flow system having a channel with at least one fluid transporting structure located in the top and bottom surfaces situated so as to transport the sheath fluid laterally across the channel to provide sheath fluid fully surrounding the core solution. At the point of introduction into the channel, the sheath fluid and core solutions flow side by side within the channel or the core solution may be bounded on either side by the sheath fluid. The system is functional over a broad channel size range and with liquids of high or low viscosity. The design can be readily incorporated into microfluidic chips without the need for special manufacturing protocols. Uses include extruding materials and/or fabricating structures.Type: ApplicationFiled: August 12, 2015Publication date: December 3, 2015Applicant: The Government of the United States of America, as represented by the Secretary of the NavyInventors: David R. Mott, Peter B. Howell, JR., Frances S. Ligler, Stephanie Fertig, Aron Bobrowski
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Publication number: 20150328636Abstract: A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.Type: ApplicationFiled: July 1, 2015Publication date: November 19, 2015Applicant: The Government of the United States of America, as represented by the Secretary of the NavyInventors: André A. Adams, Michael Daniele, Frances S. Ligler
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Publication number: 20150322408Abstract: A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.Type: ApplicationFiled: July 1, 2015Publication date: November 12, 2015Applicant: The Government of the United States of America, as represented by the Secretary of the NavyInventors: André A. Adams, Michael Daniele, Frances S. Ligler
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Patent number: 9157060Abstract: A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.Type: GrantFiled: March 4, 2013Date of Patent: October 13, 2015Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Frances S. Ligler, André A. Adams, Michael Daniele
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Publication number: 20150266226Abstract: A sheath flow system having a channel with at least one fluid transporting structure located in the top and bottom surfaces situated so as to transport the sheath fluid laterally across the channel to provide sheath fluid fully surrounding the core solution. At the point of introduction into the channel, the sheath fluid and core solutions flow side by side within the channel or the core solution may be bounded on either side by the sheath fluid. The system is functional over a broad channel size range and with liquids of high or low viscosity. The design can be readily incorporated into microfluidic chips without the need for special manufacturing protocols. Uses include extruding materials and/or fabricating structures.Type: ApplicationFiled: May 29, 2015Publication date: September 24, 2015Applicant: The Government of the United States of America, as represented by the Secretary of the NavyInventors: David R. Mott, Peter B. Howell, JR., Frances S. Ligler, Stephanie Fertig, Aron Bobrowski
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Patent number: 9110010Abstract: A device having: a laminar flow channel for liquids; two or more electrodes; a confining fluid inlet; a sample inlet; and a meter for measuring the impedance of any fluid between the electrodes. The device may have one or more specific binding sites, or it may have sheathing and unsheathing fluid transporting structures. A method of: providing the device; flowing a confining fluid and a conductive liquid that may contain cells or particles through the channel as described herein; and measuring the impedance between the electrodes.Type: GrantFiled: May 9, 2008Date of Patent: August 18, 2015Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Daniel A. Ateya, Peter B Howell, Jr., Frances S. Ligler
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Patent number: 9067204Abstract: A sheath flow system having a channel with at least one fluid transporting structure located in the top and bottom surfaces situated so as to transport the sheath fluid laterally across the channel to provide sheath fluid fully surrounding the core solution. At the point of introduction into the channel, the sheath fluid and core solutions flow side by side within the channel or the core solution may be bounded on either side by the sheath fluid. The system is functional over a broad channel size range and with liquids of high or low viscosity. The design can be readily incorporated into microfluidic chips without the need for special manufacturing protocols.Type: GrantFiled: January 10, 2011Date of Patent: June 30, 2015Assignee: The United States of America, as represented by the Secretary of the NavyInventors: David Mott, Peter B Howell, Jr., Frances S Ligler, Stephanie Fertig, Aron Bobrowski
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Patent number: 9040250Abstract: A composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6. A method of administering to an immunosuppressed patient or a patient diagnosed with sepsis or septic shock a composition having a proanthocyanidin. A method of administering to a patient diagnosed with a gram negative bacterial infection a composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6.Type: GrantFiled: August 2, 2007Date of Patent: May 26, 2015Assignee: The United States of America, as represented by the Secretary of the NavyInventors: James B Delehanty, Brandy J White, Baochuan Lin, Frances S Ligler
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Patent number: 8965710Abstract: An apparatus having within or as part of a housing; a sample port; a microarray port; a lysis module; a purification module for containing a solid phase for binding of oligonucleotides; a thermocycling module for containing a polymerase chain reaction; a fragmentation module; and a microarray module for holding a microarray and a liquid in contact with the microarray. The apparatus is configured to be coupled to a device for: pumping a liquid through, in order, the lysis, purification, thermocycling, fragmentation, and microarray modules; sonicating any contents of the lysis module; thermocycling the thermocycling module to perform the polymerase chain reaction; heating the fragmentation module to fragment any oligonucleotides contained therein; circulating a fluid over the surface of the microarray; and performing one or more washing or staining steps on the microarray.Type: GrantFiled: November 14, 2006Date of Patent: February 24, 2015Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Frances S Ligler, David A Stenger, Jeff Erickson, Marie Archer
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Patent number: 8945856Abstract: A method of biochemical identification by: providing a plurality of capture species bound to one or more substrates and suspected of having one or more biological targets affinity bound to at least one capture species; detecting which capture species contain bound biological targets to generate a binding pattern; and identifying the biological target based on the binding pattern. The capture species are independently selected from the group consisting of antimicrobial peptides, cytotoxic peptides, antibiotics, and combinations thereof. A device having the capture species bound to the substrates. At least two of the capture species are capable of multi-specific binding to one or more biological targets and may have overlapping but not identical affinity properties.Type: GrantFiled: February 25, 2014Date of Patent: February 3, 2015Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Nadezhda V. Kulagina, Chris Rowe Taitt, George P. Anderson, Frances S. Ligler