Patents by Inventor Francesca Benedini

Francesca Benedini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quinone based nitric oxide donating compounds
    Patent number: 9079821
    Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: July 14, 2015
    Assignee: NICOX SCIENCE IRELAND
    Inventors: Gael Ronsin, Laura Storoni, Francesca Benedini
  • Quinone based nitric oxide donating compounds
    Patent number: 9061962
    Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: June 23, 2015
    Assignee: Nicox Science Ireland
    Inventors: Gael Ronsin, Laura Storoni, Francesca Benedini
  • Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology
    Patent number: 9012435
    Abstract: The invention relates to nitrooxy derivatives of fluocinolone acetonide, triamcinolone acetonide, betamethasone and beclomethasone, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for treating diabetic macular edema, diabetic retinopathy, macular degeneration, age-related macular degeneration and other diseases of retina and macula lutea.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: April 21, 2015
    Assignee: Nicox S.A.
    Inventors: Francesca Benedini, Annalisa Bonfanti, Valerio Chiroli, Rebecca Steele, Ennio Ongini, Stefano Biondi
  • NITRIC OXIDE RELEASING STEROIDS
    Publication number: 20150105547
    Abstract: The invention relates to nitrooxyderivative of corticosteroids of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof R—(Z)a—Rx??(I) wherein R is the corticosteroid residue of formula (II): wherein: R1 is OH, R2 —CH3, or R1 and R2 are taken together to form a group of formula (III) R3 is Cl or F; R4 is H or F; wherein R1, R2, R3 and R4 can be linked to the correspondent carbon atoms of the steroidal structure in position ? or ?; with the proviso that: when R1 and R2 are the group of formula (III) then R3 is F and R4 is H or F; The compounds are useful in the treatment of respiratory diseases, inflammatory diseases, dermatological diseases and ocular diseases.
    Type: Application
    Filed: November 26, 2014
    Publication date: April 16, 2015
    Inventors: Francesca BENEDINI, Stefano BIONDI, Ennio ONGINI
  • Nitric oxide releasing steroids
    Patent number: 8933062
    Abstract: The invention relates to nitrooxyderivative of corticosteroids of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof R—(Z)a—Rx??(I) wherein R is the corticosteroid residue of formula (II): wherein: R1 is OH, R2—CH3, or R1 and R2 are taken together to form a group of formula (III) R3 is Cl or F; R4 is H or F; wherein R1, R2, R3 and R4 can be linked to the correspondent carbon atoms of the steroidal structure in position ? or ?; with the proviso that: when R1 and R2 are the group of formula (III) then R3 is F and R4 is H or F; The compounds are useful in the treatment of respiratory diseases, inflammatory diseases, dermatological diseases and ocular diseases.
    Type: Grant
    Filed: January 28, 2008
    Date of Patent: January 13, 2015
    Assignee: Nicox S.A.
    Inventors: Francesca Benedini, Stefano Biondi, Ennio Ongini
  • QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS
    Publication number: 20140342998
    Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
    Type: Application
    Filed: October 23, 2012
    Publication date: November 20, 2014
    Applicant: NICOX S.A.
    Inventors: Gael Ronsin, Laura Storoni, Francesca Benedini
  • QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS
    Publication number: 20140135389
    Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
    Type: Application
    Filed: January 22, 2014
    Publication date: May 15, 2014
    Inventors: Gael RONSIN, Laura STORONI, Francesca BENEDINI
  • GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY
    Publication number: 20130303499
    Abstract: The invention relates to nitrooxy derivatives of fluocinolone acetonide, triamcinolone acetonide, betamethasone and beclomethasone, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for treating diabetic macular edema, diabetic retinopathy, macular degeneration, age-related macular degeneration and other diseases of retina and macula lutea.
    Type: Application
    Filed: July 19, 2013
    Publication date: November 14, 2013
    Inventors: Francesca BENEDINI, Annalisa BONFANTI, Valerio CHIROLI, Rebecca STEELE, Ennio ONGINI, Stefano BIONDI
  • Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology
    Patent number: 8518920
    Abstract: The invention relates to nitrooxy derivatives of fluocinolone acetonide, triamcinolone acetonide, betamethasone and beclomethasone, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for treating diabetic macular edema, diabetic retinopathy, macular degeneration, age-related macular degeneration and other diseases of retina and macula lutea.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: August 27, 2013
    Assignee: Nicox S.A.
    Inventors: Francesca Benedini, Annalisa Bonfanti, Valerio Chiroli, Rebecca Steele, Ennio Ongini, Stefano Biondi
  • Nitric oxide donating prostamides
    Patent number: 8101658
    Abstract: Nitroderivatives of prostaglandins having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
    Type: Grant
    Filed: May 11, 2009
    Date of Patent: January 24, 2012
    Assignee: Nicox S.A.
    Inventors: Francesca Benedini, Stefano Biondi, Valerio Chiroli, Wesley Kwan Mung Chong, Liming Dong, Achim Hans-Peter Krauss, Fabio Nicoli, Ganesh Prasanna, William Francois Vernier, Yi Yang
  • NITROOXY DERIVATIVES OF GLUCOCORTICOIDS
    Publication number: 20110294769
    Abstract: The invention relates to new steroids nitrooxyderivatives, to topical pharmaceutical formulations thereof, and their use for treating skin or mucosal membrane diseases or disorders. These new steroids nitrooxyderivatives have an improved pharmacological activity and enhanced local tolerability.
    Type: Application
    Filed: August 10, 2011
    Publication date: December 1, 2011
    Applicants: FERRER INTERNACIONAL S.A., NICOX S.A.
    Inventors: Francesca BENEDINI, Ennio Ongini, Antonio Guglietta, Daniel Palop, Marta Princep
  • Prostaglandin derivatives
    Patent number: 8058467
    Abstract: Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: November 15, 2011
    Assignee: Nicox S.A.
    Inventors: Ennio Ongini, Valerio Chiroli, Francesca Benedini, Piero Del Soldato
  • GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY
    Publication number: 20110144073
    Abstract: The invention relates to nitrooxy derivatives of fluocinolone acetonide, triamcinolone acetonide, betamethasone and beclomethasone, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for treating diabetic macular edema, diabetic retinopathy, macular degeneration, age-related macular degeneration and other diseases of retina and macula lutea.
    Type: Application
    Filed: July 7, 2009
    Publication date: June 16, 2011
    Inventors: Francesca Benedini, Annalisa Bonfanti, Valerio Chiroli, Rebecca Steele, Ennio Ongini, Stefano Biondi
  • PROSTAGLANDIN DERIVATIVES
    Publication number: 20110136904
    Abstract: Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
    Type: Application
    Filed: February 11, 2011
    Publication date: June 9, 2011
    Applicant: NICOX S.A.
    Inventors: Ennio Ongini, Valerio Chiroli, Francesca Benedini, Piero Del Soldato
  • NEW NO-RELEASING STEROIDS FOR THE TREATMENT OF RETINA AND MACULA LUTEA DISEASES
    Publication number: 20110130375
    Abstract: The invention relates to compounds of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof The compounds are useful for treating diabetic macular edema, diabetic retinopathy, macular degeneration, age-related macular degeneration and other diseases of retina and macula lutea.
    Type: Application
    Filed: July 24, 2009
    Publication date: June 2, 2011
    Applicant: NICOX S.A.
    Inventors: Francesca Benedini, Rebecca Steele, Valerio Chiroli, Stefano Biondi, Ennio Ongini
  • NEW NO RELEASING STEROIDS DERIVATIVES
    Publication number: 20110130376
    Abstract: The invention relates to compounds of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof The compounds are useful in the treatment of illnesses wherein the known steroid, parent or precursor steroid, is generally applied, with increased benefit in terms of pharmacological profile and fewer or milder side effects than those of the known steroids.
    Type: Application
    Filed: July 24, 2009
    Publication date: June 2, 2011
    Applicant: NICOX S.A.
    Inventors: Francesca Benedini, Laura Carzaniga, Ennio Ongini, Stefamo Biondi
  • NITRIC OXIDE DONATING PROSTAMIDES
    Publication number: 20110092590
    Abstract: Nitroderivatives of prostaglandins having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
    Type: Application
    Filed: May 11, 2009
    Publication date: April 21, 2011
    Applicant: NICOX S.A.
    Inventors: Francesca Benedini, Stefano Biondi, Valerio Chiroli, Wesley Kwan Mung Chong, Liming Dong, Achim Hans-Peter Krauss, Fabio Nicoli, Ganesh Prasanna, William Francois Vernier, Yi Yang
  • Prostaglandin derivatives
    Patent number: 7910767
    Abstract: Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: March 22, 2011
    Assignee: Nicox S.A.
    Inventors: Ennio Ongini, Valerio Chiroli, Francesca Benedini, Piero Del Soldato
  • COMPOSITION COMPRISING A NITROOXYDERIVATIVE OF ACETAMINOPHEN AND A ANTICONVULSANT DRUG FOR THE TREATMENT OF NEUROPATHIC PAIN
    Publication number: 20100286264
    Abstract: The present invention relates to compositions comprising a nitric oxide releasing paracetamol and an anticonvulsant drug. The compositions of the invention can be used use in the treatment of neuropathic pain in particular diabetic neuropathic pain, painful post-infarct syndrome, pain caused by chemotherapeutic treatment or pain arising from infections by viral agents.
    Type: Application
    Filed: December 9, 2008
    Publication date: November 11, 2010
    Applicant: Nicox S.A.
    Inventors: Francesco Impagnatiello, Juan F. Herrero, Francesca Benedini
  • Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive
    Patent number: 7825263
    Abstract: The present invention relates to ?-adrenergic blockers nitrooxyderivatives of general formula (I): A-(Y—ONO2)s and enantiomers and diastereoisomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them and their use for the treatment of hypertension, cardiovascular diseases, glaucoma, migraine headache and vascular diseases.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: November 2, 2010
    Assignee: Nicox S.A.
    Inventors: Piero Del Soldato, Francesca Benedini, Ennio Ongini