Patents by Inventor Francesca Demichelis
Francesca Demichelis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240287615Abstract: The present invention provides an in vitro method, and in vitro assay, for staging, classification, screening, monitoring, stratification, selecting treatment for, ascertaining whether treatment is working in, and/or prognostication of cancer in a subject comprising determining allelic imbalance and copy number of target gene-regions in tumor DNA from a subject as set out in the application. The present invention also provides a set of oligonucleotide probes and kits for use in the method, and assay, of the present invention.Type: ApplicationFiled: June 9, 2022Publication date: August 29, 2024Applicants: University College London, Università degli Studi di Trento, Cornell University, The University of British ColumbiaInventors: Gerhardt Attard, Francesca Demichelis, Alessandro Romanel, Francesco Orlando, Mark Rubin, Himisha Beltran, Alexander Wyatt
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Publication number: 20230105008Abstract: The present invention is based on the identification of castration resistant neuroendocrine prostate cancer (CRPC-NE) features in the circulation, and relates to methods and compositions of identifying CRPC-NE patients by detecting these features.Type: ApplicationFiled: February 8, 2021Publication date: April 6, 2023Inventors: Himisha Beltran, Francesca Demichelis, Gian Marco Franceschini, Alessandro Romanel
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Publication number: 20220389523Abstract: In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.Type: ApplicationFiled: August 5, 2022Publication date: December 8, 2022Inventors: Francesca Demichelis, Karl Garsha, Phillip C. Miller, Ray B. Nagle, Michael Otter, Gary Anthony Pestano, Mark Rubin
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Patent number: 11441189Abstract: In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.Type: GrantFiled: April 12, 2018Date of Patent: September 13, 2022Assignees: Ventana Medical Systems, Inc., Cornell UniversityInventors: Francesca Demichelis, Karl Garsha, Phillip C. Miller, Ray B. Nagle, Michael Otter, Gary Anthony Pestano, Mark Rubin
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Patent number: 10190173Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.Type: GrantFiled: May 9, 2016Date of Patent: January 29, 2019Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
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Publication number: 20180291464Abstract: In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.Type: ApplicationFiled: April 12, 2018Publication date: October 11, 2018Inventors: Francesca Demichelis, Karl Garsha, Phillip C. Miller, Ray B. Nagle, Michael Otter, Gary Anthony Pestano, Mark Rubin
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Patent number: 9951388Abstract: In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.Type: GrantFiled: May 7, 2012Date of Patent: April 24, 2018Assignees: Ventana Medical Systems, Inc., Cornell UniversityInventors: Francesca Demichelis, Karl Garsha, Phillip C. Miller, Ray B. Nagle, Michael Otter, Gary Anthony Pestano, Mark Rubin
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Patent number: 9745635Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.Type: GrantFiled: September 24, 2015Date of Patent: August 29, 2017Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
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Patent number: 9678077Abstract: This invention relates to a triple immunostaining assay (ERG/TFF3/HMWCK) for sensitive and specific detection of prostate cancer. Positive staining for at least one of ERG or TFF3 combined with negative staining of HMWCK in a sample such as prostate tissue sample is indicative of cancer.Type: GrantFiled: May 15, 2013Date of Patent: June 13, 2017Assignee: CORNELL UNIVERSITYInventors: Mark A. Rubin, Juan Miguel Mosquera, Kyung Park, Ya-Lin Chiu, Francesca Demichelis
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Publication number: 20160319369Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.Type: ApplicationFiled: May 9, 2016Publication date: November 3, 2016Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
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Publication number: 20160097104Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.Type: ApplicationFiled: September 24, 2015Publication date: April 7, 2016Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
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Patent number: 9284609Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.Type: GrantFiled: May 30, 2012Date of Patent: March 15, 2016Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
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Publication number: 20150197811Abstract: In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.Type: ApplicationFiled: April 23, 2013Publication date: July 16, 2015Applicants: CORNELL UNIVERSITY, VENTANA MEDICAL SYSTEMS, INC.Inventors: Francesca Demichelis, Karl Garsha, Phillip C. Miller, Ray B. Nagle, Michael Otter, Gary Anthony Pestano, Mark Rubin
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Publication number: 20150132767Abstract: This invention relates to a triple immunostaining assay (ERG/TFF3/HMWCK) for sensitive and specific detection of prostate cancer. Positive staining for at least one of ERG or TFF3 combined with negative staining of HMWCK in a sample such as prostate tissue sample is indicative of cancer.Type: ApplicationFiled: May 15, 2013Publication date: May 14, 2015Applicant: CORNELL UNIVERSITYInventors: Mark A. Rubin, Juan Miguel Mosquera, Kyung Park, Ya-Lin Chiu, Francesca Demichelis
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Patent number: 8969527Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.Type: GrantFiled: May 30, 2012Date of Patent: March 3, 2015Assignees: The Regents of the University of Michigan, The Brigham and Women's Hospital, Inc.Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
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Publication number: 20140296088Abstract: In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.Type: ApplicationFiled: April 23, 2013Publication date: October 2, 2014Applicants: CORNELL UNIVERSITY, VENTANA MEDICAL SYSTEMS, INC.Inventors: Francesca Demichelis, Karl Garsha, Phillip C. Miller, Ray B. Nagle, Michael Otter, Gary Anthony Pestano, Mark Rubin
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Patent number: 8580509Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.Type: GrantFiled: May 30, 2012Date of Patent: November 12, 2013Assignees: The Regents of The University of Michigan, The Brigham and Women's Hospital, Inc.Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
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Publication number: 20130040858Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.Type: ApplicationFiled: May 30, 2012Publication date: February 14, 2013Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
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Publication number: 20120295809Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.Type: ApplicationFiled: May 30, 2012Publication date: November 22, 2012Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
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Publication number: 20120296070Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.Type: ApplicationFiled: May 30, 2012Publication date: November 22, 2012Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis