Patents by Inventor Francesca Demichelis

Francesca Demichelis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10190173
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: January 29, 2019
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Publication number: 20180291464
    Abstract: In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.
    Type: Application
    Filed: April 12, 2018
    Publication date: October 11, 2018
    Inventors: Francesca Demichelis, Karl Garsha, Phillip C. Miller, Ray B. Nagle, Michael Otter, Gary Anthony Pestano, Mark Rubin
  • Patent number: 9951388
    Abstract: In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: April 24, 2018
    Assignees: Ventana Medical Systems, Inc., Cornell University
    Inventors: Francesca Demichelis, Karl Garsha, Phillip C. Miller, Ray B. Nagle, Michael Otter, Gary Anthony Pestano, Mark Rubin
  • Patent number: 9745635
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: August 29, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Patent number: 9678077
    Abstract: This invention relates to a triple immunostaining assay (ERG/TFF3/HMWCK) for sensitive and specific detection of prostate cancer. Positive staining for at least one of ERG or TFF3 combined with negative staining of HMWCK in a sample such as prostate tissue sample is indicative of cancer.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: June 13, 2017
    Assignee: CORNELL UNIVERSITY
    Inventors: Mark A. Rubin, Juan Miguel Mosquera, Kyung Park, Ya-Lin Chiu, Francesca Demichelis
  • Publication number: 20160319369
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Application
    Filed: May 9, 2016
    Publication date: November 3, 2016
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Publication number: 20160097104
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Application
    Filed: September 24, 2015
    Publication date: April 7, 2016
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Patent number: 9284609
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: March 15, 2016
    Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Publication number: 20150197811
    Abstract: In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.
    Type: Application
    Filed: April 23, 2013
    Publication date: July 16, 2015
    Applicants: CORNELL UNIVERSITY, VENTANA MEDICAL SYSTEMS, INC.
    Inventors: Francesca Demichelis, Karl Garsha, Phillip C. Miller, Ray B. Nagle, Michael Otter, Gary Anthony Pestano, Mark Rubin
  • Publication number: 20150132767
    Abstract: This invention relates to a triple immunostaining assay (ERG/TFF3/HMWCK) for sensitive and specific detection of prostate cancer. Positive staining for at least one of ERG or TFF3 combined with negative staining of HMWCK in a sample such as prostate tissue sample is indicative of cancer.
    Type: Application
    Filed: May 15, 2013
    Publication date: May 14, 2015
    Applicant: CORNELL UNIVERSITY
    Inventors: Mark A. Rubin, Juan Miguel Mosquera, Kyung Park, Ya-Lin Chiu, Francesca Demichelis
  • Patent number: 8969527
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: March 3, 2015
    Assignees: The Regents of the University of Michigan, The Brigham and Women's Hospital, Inc.
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Publication number: 20140296088
    Abstract: In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.
    Type: Application
    Filed: April 23, 2013
    Publication date: October 2, 2014
    Applicants: CORNELL UNIVERSITY, VENTANA MEDICAL SYSTEMS, INC.
    Inventors: Francesca Demichelis, Karl Garsha, Phillip C. Miller, Ray B. Nagle, Michael Otter, Gary Anthony Pestano, Mark Rubin
  • Patent number: 8580509
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: November 12, 2013
    Assignees: The Regents of The University of Michigan, The Brigham and Women's Hospital, Inc.
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Publication number: 20130040858
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Application
    Filed: May 30, 2012
    Publication date: February 14, 2013
    Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Publication number: 20120295809
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Application
    Filed: May 30, 2012
    Publication date: November 22, 2012
    Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Publication number: 20120296070
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Application
    Filed: May 30, 2012
    Publication date: November 22, 2012
    Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Patent number: 8211645
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: July 3, 2012
    Assignees: The Regents of the University of Michigan, The Brigham and Women's Hospital
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Patent number: 7981609
    Abstract: Described are methods for identifying single nucleotide polymorphism (SNPs) that are useful for analyzing genetic samples, and for using said SNPs to determine genetic identity of samples.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: July 19, 2011
    Assignees: The Brigham and Women's Hospital, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Mark A. Rubin, Francesca Demichelis, Levi A. Garraway, William R. Sellers
  • Publication number: 20110034677
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Application
    Filed: December 30, 2009
    Publication date: February 10, 2011
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Patent number: 7803552
    Abstract: The present invention relates to the identification and use of gene expression profiles with clinical relevance to prostate cancer. In particular, the invention provides the identity of genes whose expression, at the transcriptional and protein levels, is correlated with prostate cancer progression. Methods and kits are described for using these gene expression profiles in the study and/or diagnosis of prostate cancer diseases, in the prediction of prostate cancer progression, and in the selection and/or monitoring of treatment regimens. The invention also relates to the screening of drugs that target these genes or their protein products, in particular for the development of therapeutics for modulating prostate cancer progression.
    Type: Grant
    Filed: October 27, 2009
    Date of Patent: September 28, 2010
    Assignee: The Brigham & Women's Hospital, Inc.
    Inventors: Mark A. Rubin, Francesca DeMichelis