Patents by Inventor Francesca Granucci

Francesca Granucci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NANOCONSTRUCTS WITH PHARMACOLOGICAL ACTIVITY
    Publication number: 20150224061
    Abstract: The present invention relates to methods and means of transport of active substances in the cell cytosol. In particular, the invention relates to means that make it possible to transport directly in the cytosol substances capable of interacting with protein systems, such as the family of nuclear factors of activated T-cells (NFATs) or nucleic acids localized in the cytosol. In particular, the invention relates to nanoconstructs useful in the treatment of inflammatory diseases, methods for their preparation, and compositions containing them.
    Type: Application
    Filed: July 19, 2013
    Publication date: August 13, 2015
    Inventors: Francesca Granucci, Davide Prosperi, Ivan Zanoni, Fabio Ruggero Maria Corsi, Miriam Colombo
  • Dendritic cells and the uses thereof in screening cellular targets and potential drugs
    Patent number: 7442547
    Abstract: The present invention is based on the discovery that in response to different stimuli, dendritic cells initiate various immune responses by producing different transcription profiles, e.g., IL-2 production by dendritic cells in response to a microbial stimulus. The present invention provides methods of making libraries of gene expression profiles and libraries made thereof corresponding to dendritic cell maturation in response to a microbial stimulation. The present invention provides methods for activating lymphocytes or immune responses and methods for producing Il-2 in dendritic cells or preparing dendritic cells for cell-based therapy. The present invention also provides methods and systems for screening agents affecting dendritic cell maturation. In addition, it is the discovery of the present invention that dendritic cells are targets for immunosuppressive virus infections.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: October 28, 2008
    Assignee: Sekmed, S.R.L.
    Inventors: Francesca Granucci, Paola Ricciardi-Castagnoli
  • Dendritic cells and the uses thereof in screening cellular targets and potential drugs
    Publication number: 20030152550
    Abstract: The present invention is based on the discovery that in response to different stimuli, dendritic cells initiate various immune responses by producing different transcription profiles, e.g., IL-2 production by dendritic cells in response to a microbial stimulus. The present invention provides methods of making libraries of gene expression profiles and libraries made thereof corresponding to dendritic cell maturation in response to a microbial stimulation. The present invention provides methods for activating lymphocytes or immune responses and methods for producing Il-2 in dendritic cells or preparing dendritic cells for cell-based therapy. The present invention also provides methods and systems for screening agents affecting dendritic cell maturation. In addition, it is the discovery of the present invention that dendritic cells are targets for immunosuppressive virus infections.
    Type: Application
    Filed: July 31, 2002
    Publication date: August 14, 2003
    Inventors: Francesca Granucci, Mariapia Degli Esposti, Paola Ricciardi-Castagnoli
  • Immortalization of dendritic cells with v-myc oncogene
    Patent number: 6156307
    Abstract: The present invention refers to immortalized dendritic cells, to a process for their production from primary cultures and to their use for the activation, in vivo or in vitro, of T lymphocytes in antigen specific way.
    Type: Grant
    Filed: January 2, 1998
    Date of Patent: December 5, 2000
    Assignee: Biotop s.a.s. di Rita Cassarin
    Inventor: Francesca Granucci
  • Immortalization of dendritic cells with V-MYC oncogene
    Patent number: 5856180
    Abstract: The present invention refers to immortalized dendritic cells, to a process for their production from primary cultures and to their use for the activation, in vivo or in vitro, of T lymphocytes in antigen specific way.
    Type: Grant
    Filed: November 29, 1995
    Date of Patent: January 5, 1999
    Assignee: BIOTOP s.a.s. di Rita Cassarin
    Inventor: Francesca Granucci