Patents by Inventor Francesca MALERBA

Francesca MALERBA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • proNGF mutants and uses thereof for the preparation of NGF mutants
    Publication number: 20180086805
    Abstract: Pro-NGF—Nerve Growth Factor—mutants and their uses for the production of NGF mutants are disclosed. Also disclosed are useful new process to optimize and improve the purification of NGF P61SR100E, a therapeutic protein. The invention further provides a mutant pro-NGF wherein the protease cleavage site RASKRB is substituted at least at position RA and K by a non-basic amino acid, and the mutant pro-NGF further includes at least one mutation selected from P165S or R204E.
    Type: Application
    Filed: May 12, 2017
    Publication date: March 29, 2018
    Inventors: Antonino CATTANEO, Francesca MALERBA