Patents by Inventor Francesca Micoli

Francesca Micoli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYSACCHARIDE IMMUNOGENS CONJUGATED TO E. COLI CARRIER PROTEINS
    Publication number: 20120308600
    Abstract: E. coli proteins have been identified that are useful as carrier proteins to improve a response to a polysaccharide immunogen conjugated to such protein. In particular, AcfD precursor protein (orf3526 polypeptide), Flu antigen 43 protein (orf1364 polypeptide), and Sel1 repeat-containing protein (upec-5211 polypeptide) have been shown to be effective. Additionally, these E. coli proteins can enhance the immune response to glucans, particularly fungal glucans.
    Type: Application
    Filed: December 30, 2010
    Publication date: December 6, 2012
    Applicant: Novartis AG
    Inventors: Paolo Costantino, Francesco Berti, Francesca Micoli, Anna Kasanova, Laura Serino, Maria Rosaria Romano, Marta Tortini
  • ANALYSIS OF VI SACCHARIDES
    Publication number: 20110159602
    Abstract: Salmonella typhi Vi saccharide can be assayed in two new ways. First, its proton NMR spectrum can be used, with comparison to an internal Standard permitting quantitative analysis. Second, anion exchange chromatography with amperometric detection can be used on hydrolysed saccharide.
    Type: Application
    Filed: June 12, 2009
    Publication date: June 30, 2011
    Inventors: Francesco Berti, Francesca Micoli, Daniela Proietti
  • CONJUGATED VI SACCHARIDES
    Publication number: 20110142876
    Abstract: Two Vi conjugates have been prepared by carbodiimide-mediated synthesis, using adipic acid dihydrazide derivatized CRM197 (a non-toxic variant of diphtheria toxin) and tetanus toxoid, as carrier proteins.
    Type: Application
    Filed: June 12, 2009
    Publication date: June 16, 2011
    Inventors: Francesca Micoli, Paolo Costantino, Francesco Berti