Patents by Inventor Francesca Orlandi

Francesca Orlandi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RADIOLABELLED GRPR-ANTAGONIST FOR USE AS THERAGNOSTIC
    Publication number: 20230321287
    Abstract: The present disclosure relates to gastrin-releasing peptide receptor (GRPR) targeting pharmaceuticals and their use in a theragnostic approach for selection and therapy of subjects with GRPR-expressing malignancies. In particular, the present disclosure relates to a pharmaceutical composition of a radiolabeled GRPR-antagonist, for use in treating GRPR-positive tumors in a human subject selected for said treatment, wherein said subject has been selected for the treatment by PET/CT or PET/MRI imaging with a corresponding 68Ga-labelled GRPR antagonist as contrast agent.
    Type: Application
    Filed: September 23, 2020
    Publication date: October 12, 2023
    Inventors: Daniela CHICCO, Maurizio F. MARIANI, Francesca ORLANDI, Antje WEGENER
  • STABLE, CONCENTRATED RADIOPHARMACEUTICAL COMPOSITION
    Publication number: 20220401593
    Abstract: The present disclosure relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.
    Type: Application
    Filed: September 15, 2020
    Publication date: December 22, 2022
    Inventors: Donato BARBATO, Lorenza FUGAZZA, Maurizio F. MARIANI, Francesca ORLANDI, Lorenzo SACCHETTI, Mattia TEDESCO
  • METHODS FOR RADIOLABELLING GRPR ANTAGONISTS AND THEIR KITS
    Publication number: 20220378954
    Abstract: The present invention relates to methods for radiolabelling GRPR antagonists such as NeoB, and their kits. In particular, the invention to a method for labeling a gastrin-releasing peptide receptor (GRPR) antagonist with a radioactive isotope, preferably 68Ga, 67Ga or 64Cu, said method comprising the steps of: i. providing a first vial comprising said GRPR antagonist in dried form, ii. adding a solution of said radioactive isotope into said first vial, thereby obtaining a solution of said GRPR antagonist with said radioactive isotope, iii. mixing the solution obtained in ii. with at least a buffering agent and incubating it for a sufficient period of time for obtaining said GRPR antagonist labeled with said radioactive isotope, and, iv. optionally, adjusting the pH of the solution.
    Type: Application
    Filed: September 16, 2020
    Publication date: December 1, 2022
    Inventors: Elena CASTALDI, Lorenza FUGAZZA, Maurizio F. MARIANI, Francesca ORLANDI, Mattia TEDESCO
  • PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) LIGANDS AND USES THEREOF
    Publication number: 20220273826
    Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) ligands In particular, the disclosure relates to PSMA ligands having a glutamate-urea-lysine (GUL) moiety, a radioisotope and a chelating agent that can comprise a radiometal.
    Type: Application
    Filed: June 30, 2020
    Publication date: September 1, 2022
    Inventors: Maurizio F. MARIANI, Donato BARBATO, Francesca ORLANDI
  • Lyophilized Compositions Comprising Rhannexin V-128, Process for Their Preparation and Their Use for Preparing Formulations Containing 99MTc-Rhannexin V-128
    Publication number: 20220031872
    Abstract: It is described a composition comprising lyophilized rhAnnexin V-128 suitable for the preparation of 99mTc-rhAnnexin V-128 formulations suitable for intravenous administration.
    Type: Application
    Filed: August 10, 2021
    Publication date: February 3, 2022
    Applicant: Advanced Accelerator Applications International S.A.
    Inventors: Lorenza Fugazza, Maurizio Franco Mariani, Francesca Orlandi, Daniela Chicco, Donato Barbato
  • Pharmaceutical Composition Comprising a Radiolabeled GRPR Antagonist and a Surfactant
    Publication number: 20220008566
    Abstract: The present disclosure relates to gastrin-releasing peptide receptor (GRPR) targeting radiopharmaceuticals and uses thereof. In particular, the present disclosure relates to a pharmaceutical composition comprising radiolabeled GRPR-antagonist and a surfactant. The present disclosure also relates to radiolabeled GRPR-antagonist for use in treating or preventing a cancer.
    Type: Application
    Filed: October 11, 2019
    Publication date: January 13, 2022
    Applicant: Advanced Accelerator Applications International SA
    Inventors: Francesca Orlandi, Lorenza Fugazza, Donato Barbato, Mattia Tedesco, Lorenzo Sacchetti
  • Combination Therapy
    Publication number: 20210346527
    Abstract: The present invention relates to combination therapies of radiolabelled somatostatin receptor binding compounds with PARR inhibitors.
    Type: Application
    Filed: September 24, 2019
    Publication date: November 11, 2021
    Applicant: Advanced Accelerator Applications (Italy) SRL
    Inventors: Maurizio F. Mariani, Francesca Orlandi, Daniela Chicco, Valeria Muzio, Carmelina Angotti
  • Lyophilized Compositions Comprising Rhannexin V-128, Process for Their Preparation and Their Use for Preparing Formulations Containing 99MTc-Rhannexin V-128
    Publication number: 20200038526
    Abstract: It is described a composition comprising lyophilized rhAnnexin V-128 suitable for the preparation of 99mTc-rhAnnexin V-128 formulations suitable for intravenous administration.
    Type: Application
    Filed: October 11, 2017
    Publication date: February 6, 2020
    Applicant: Advanced Accelerator Applications International S.A.
    Inventors: Lorenza Fugazza, Maurizio Franco Mariani, Francesca Orlandi, Daniela Chicco, Donato Barbato