Patents by Inventor Francesca Pavone

Francesca Pavone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYCLIC PEPTIDES FOR TRAPPING INTERLEUKIN-1 BETA
    Publication number: 20230406885
    Abstract: Provided are compounds of the Formula (I), or their pharmaceutically acceptable salts, wherein X1, X2, X3, A1, A2, R1-R7, R8a, R8b, R9a, R9b, R10 and R11 are as herein described. can trap IL-1? and are expected to have utility as therapeutic agents, for example, for treating cardiovascular disease and inflammatory disorders. The disclosure also provides pharmaceutical compositions which comprise the compounds disclosed herein or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cardiovascular disease and inflammatory disorders and for preparing pharmaceuticals for this purpose.
    Type: Application
    Filed: June 13, 2023
    Publication date: December 21, 2023
    Applicant: MERCK SHARP & DOHME LLC
    Inventors: Faben A. Cruz, Danqing Feng, Zhuyan Guo, Jennifer Hanisak, Jennifer L. Hickey, Charles Lee Jayne, Ahmet Kekec, Michael Man-Chu Lo, Christopher W. Plummer, Elisabetta Bianchi, Stefania Colarusso, Emanuela Nizi, Francesca Pavone, Ali Munaim Yousif
  • Heteroaryl derivatives of N-{[(1S,4S,6S)-3-(2-pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methyl}-2-amine
    Patent number: 8133908
    Abstract: Disclosed are N-{[(1S,4S,6S)-3-(2-pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methyl}-2-heteroarylamine derivatives having the following formula: wherein m, n, Het, R1, R2 and R3 are as defined herein, and their use as orexin antagonists.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: March 13, 2012
    Assignee: Glaxo Group Limited
    Inventors: Giuseppe Alvaro, David Amantini, Emiliano Castiglioni, Romano Di Fabio, Francesca Pavone
  • 3-AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS
    Publication number: 20120040991
    Abstract: Disclosed are 3-azabicyclo[4.1.0]heptane derivatives of formula (I) and their use as orexin receptor antagonists.
    Type: Application
    Filed: April 23, 2010
    Publication date: February 16, 2012
    Applicant: Glaxo Group Limited
    Inventors: David Amantini, Romano Di Fabio, Massimo Gianotti, Francesca Pavone, Francesco Ferroni
  • N-PHENYL HYDRAZIDES AS MODULATORS OF THE GHRELIN RECEPTOR
    Publication number: 20100286152
    Abstract: The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof,
    Type: Application
    Filed: June 5, 2008
    Publication date: November 11, 2010
    Applicant: Glaxo Group Limited
    Inventors: Giovanni Bernasconi, Steven Mark Bromidge, Andrew James Carpenter, Lucilla D'Adamo, Romano Di Fabio, Sebastien Guery, Francesca Pavone, Alfonso Pozzan, Marilisa Rinaldi, Fabio Maria Sabbatini, Yves St-Denis
  • Novel compounds
    Publication number: 20100190764
    Abstract: This invention relates to novel Spiro cyclopentane derivatives of formula (I) or a pharmaceutically acceptable salt thereof, for treating diseases and conditions of the central nervous system (CNS), in particular sleep disorders.
    Type: Application
    Filed: July 24, 2008
    Publication date: July 29, 2010
    Inventors: Emiliano Castiglioni, Romano Di Fabio, Massimo Gianotti, Milan Mesic, Francesca Pavone, Slavko Rast, Luigi Piero Stasi
  • NOVEL COMPOUNDS
    Publication number: 20100168131
    Abstract: Disclosed are N-{[(1S,4S,6S)-3-(2-pyridinylcarbonyl)-3-azabicyclo [4.1.0]hept-4-yl]methyl}-2-heteroarylamine derivatives and their use as pharmaceuticals.
    Type: Application
    Filed: November 30, 2009
    Publication date: July 1, 2010
    Inventors: Giuseppe Alvaro, David Amantini, Emiliano Castiglioni, Romano Di Fabio, Francesca Pavone
  • NOVEL COMPOUNDS
    Publication number: 20100144760
    Abstract: Disclosed are N-{[(1R,4S,6R)-3-(2-pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methyl}-2-heteroarylamine derivatives and their use as pharmaceuticals.
    Type: Application
    Filed: November 30, 2009
    Publication date: June 10, 2010
    Inventors: Giuseppe ALVARO, David Amantini, Emiliano Castiglioni, Romano Di Fabio, Francesca Pavone