Patents by Inventor Francesca Quartieri

Francesca Quartieri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
    Publication number: 20210300935
    Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: October 30, 2020
    Publication date: September 30, 2021
    Inventors: Gabriella TRAQUANDI, Maria Gabriella BRASCA, Roberto D'ALESSIO, Paolo POLUCCI, Fulvia ROLETTO, Anna VULPETTI, Paolo PEVARELLO, Achille PANZERI, Francesca QUARTIERI, Ron FERGUSON, Paola VIANELLO, Daniele FANCELLI
  • Substituted pyrazolo[4,3-h]quinazolines as choline kinase inhibitors
    Patent number: 11117901
    Abstract: The present invention relates to substituted pyrazolo-quinazoline derivatives which modulate the activity of Choline Kinase (ChoK). The compounds of this invention are therefore useful in treating diseases caused by an altered choline metabolism, such as cancer, cell proliferative disorders, infectious diseases of different origin, immune-related disorders and neurodegenerative disorders. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: September 14, 2021
    Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Alessandra Badari, Elena Casale, Marcella Nesi, Francesca Quartieri
  • Purine and 3-deazapurine analogues as choline kinase inhibitors
    Patent number: 10683292
    Abstract: There are provided substituted purine and 3-deazapurine analogues, which modulate the activity of Choline Kinase (ChoK). The compounds of this invention are therefore useful in treating diseases caused by an altered choline metabolism, such as cancer, cell proliferative disorders, infectious diseases of different origin, immune-related disorders and neurodegenerative disorders. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: June 16, 2020
    Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Elena Casale, Emiliana Corti, Paola Gnocchi, Marcella Nesi, Sten Christian Orrenius, Francesca Quartieri, Federico Riccardi Sirtori
  • PYRAZOLO-QUINAZOLINE DERIVATIVES AS CHOLINE KINASE INHIBITORS
    Publication number: 20200131188
    Abstract: The present invention relates to substituted pyrazolo-quinazoline derivatives which modulate the activity of Choline Kinase (ChoK). The compounds of this invention are therefore useful in treating diseases caused by an altered choline metabolism, such as cancer, cell proliferative disorders, infectious diseases of different origin, immune-related disorders and neurodegenerative disorders. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: July 3, 2018
    Publication date: April 30, 2020
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Alessandra BADARI, Elena CASALE, Marcella NESI, Francesca QUARTIERI
  • PURINE AND 3-DEAZAPURINE ANALOGUES AS CHOLINE KINASE INHIBITORS
    Publication number: 20190225615
    Abstract: There are provided substituted purine and 3-deazapurine analogues, which modulate the activity of Choline Kinase (ChoK). The compounds of this invention are therefore useful in treating diseases caused by an altered choline metabolism, such as cancer, cell proliferative disorders, infectious diseases of different origin, immune-related disorders and neurodegenerative disorders. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: July 19, 2017
    Publication date: July 25, 2019
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Elena CASALE, Emliana CORTI, Paola GNOCCHI, Marcella NESI, Sten Christian ORRENIUS, Francesca QUARTIERI, Federico RICCARDI SIRTORI
  • PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
    Publication number: 20190194214
    Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: March 4, 2019
    Publication date: June 27, 2019
    Inventors: Gabriella TRAQUANDI, Maria Gabriella BRASCA, Roberto D'ALESSIO, Paolo POLUCCI, Fulvia ROLETTO, Anna VULPETTI, Paolo PEVARELLO, Achille PANZERI, Francesca QUARTIERI, Ron FERGUSON, Paola VIANELLO, Daniele FANCELLI
  • Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
    Patent number: 10280176
    Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: May 7, 2019
    Assignee: Nerviano Medical Sciences S.R.L.
    Inventors: Gabriella Traquandi, Maria Gabriella Brasca, Roberto D'Alessio, Paolo Polucci, Fulvia Roletto, Anna Vulpetti, Paolo Pevarello, Achille Panzeri, Francesca Quartieri, Ron Ferguson, Paola Vianello, Daniele Fancelli
  • 6-amino-7-bicyclo-7-deaza-purine derivatives as protein kinase inhibitors
    Patent number: 10221181
    Abstract: 6-Amino-7-bicyclo-7-deaza-purine derivatives of formula (I): modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: March 5, 2019
    Assignee: NERVIANO MEDICAL SCIENCES S.r.l.
    Inventors: Laura Buffa, Maria Menichincheri, Ilaria Motto, Francesca Quartieri
  • 6-AMINO-7-BICYCLO-7-DEAZA-PURINE DERIVATIVES AS PROTEIN KINASE INHIBITORS
    Publication number: 20170327506
    Abstract: The present invention relates to 6-amino-7-bicyclo-7-deaza-purine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.
    Type: Application
    Filed: November 12, 2015
    Publication date: November 16, 2017
    Applicant: NERVIANO MEICAL SCIENCES S.r.l.
    Inventors: Laura BUFFA, Maria MENICHINCHERI, Ilaria MOTTO, Francesca QUARTIERI
  • PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
    Publication number: 20170190714
    Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: March 23, 2017
    Publication date: July 6, 2017
    Inventors: Gabriella TRAQUANDI, Maria Gabriella BRASCA, Roberto D'ALESSIO, Paolo POLUCCI, Fulvia ROLETTO, Anna VULPETTI, Paolo PEVARELLO, Achille PANZERI, Francesca QUARTIERI, Ron FERGUSON, Paola VIANELLO, Daniele FANCELLI
  • Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
    Patent number: 9637497
    Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: May 2, 2017
    Assignee: Nerviano Medical Sciences, S.R.L.
    Inventors: Gabriella Traquandi, Maria Gabriella Brasca, Roberto D'Alessio, Paolo Polucci, Fulvia Roletto, Anna Vulpetti, Paolo Pevarello, Achille Panzeri, Francesca Quartieri, Ron Ferguson, Paola Vianello, Daniele Fancelli
  • Substituted pyrimidinyl and pyridinyl-pyrrolopyridinones, process for their preparation and their use as kinase inhibitors
    Patent number: 9604980
    Abstract: The present invention relates to substituted pyrimidinyl- and pyridinylpyrrolopyridinone compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: March 28, 2017
    Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Maria Menichincheri, Mauro Angiolini, Jay Aaron Bertrand, Michele Caruso, Paolo Polucci, Francesca Quartieri, Barbara Salom, Matteo Salsa, Fabio Zuccotto
  • PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
    Publication number: 20170050972
    Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: September 6, 2016
    Publication date: February 23, 2017
    Inventors: Gabriella Traquandi, Maria Gabriella Brasca, Roberto D'Alessio, Paolo Polucci, Fulvia Roletto, Anna Vulpetti, Paolo Pevarello, Achille Panzeri, Francesca Quartieri, Ron Ferguson, Paola Vianello, Daniele Fancelli
  • Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
    Patent number: 9464090
    Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: October 11, 2016
    Assignee: Nerviano Medical Sciences S.R.L.
    Inventors: Gabriella Traquandi, Maria Gabriella Brasca, Roberto D'Alessio, Paolo Polucci, Fulvia Roletto, Anna Vulpetti, Paolo Pevarello, Achille Panzeri, Francesca Quartieri, Ron Ferguson, Paola Vianello, Daniele Fancelli
  • Pyrazolyl-pyrimidine derivatives as kinase inhibitors
    Patent number: 9284298
    Abstract: The present invention relates to pyrazolyl-pyrimidine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.
    Type: Grant
    Filed: April 3, 2012
    Date of Patent: March 15, 2016
    Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Francesco Casuscelli, Maria Gabriella Brasca, Marina Caldarelli, Giovanni Cervi, Teresa Disingrini, Francesca Quartieri
  • SUBSTITUTED PYRIMIDINYL AND PYRIDINYL-PYRROLOPYRIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
    Publication number: 20150299192
    Abstract: The present invention relates to substituted pyrimidinyl- and pyridinylpyrrolopyridinone compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.
    Type: Application
    Filed: October 31, 2013
    Publication date: October 22, 2015
    Applicant: NERVIANO MEDICAL SCIENCES S.r.l.
    Inventors: Maria MENICHINCHERI, Mauro ANGIOLINI, Jay Aaron BERTRAND, Michele CARUSO, Paolo POLUCCI, Francesca QUARTIERI, Barbara SALOM, Matteo SALSA, Fabio ZUCCOTTO
  • PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
    Publication number: 20150158876
    Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: February 18, 2015
    Publication date: June 11, 2015
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Gabriella Traquandi, Maria Gabriella Brasca, Roberto D'Alessio, Paolo Polucci, Fulvia Roletto, Anna Vulpetti, Paolo Pevarello, Achille Panzeri, Francesca Quartieri, Ron Ferguson, Paola Vianello, Daniele Fancelli
  • Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
    Patent number: 8981089
    Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Grant
    Filed: August 21, 2013
    Date of Patent: March 17, 2015
    Assignee: Nerviano Medical Sciences S.R.L.
    Inventors: Gabriella Traquandi, Maria Gabriella Brasca, Roberto D'Alessio, Paolo Polucci, Fulvia Roletto, Anna Vulpetti, Paolo Pevarello, Achille Panzeri, Francesca Quartieri, Ron Ferguson, Paola Vianello, Daniele Fancelli
  • Tricyclic derivatives, process for their preparation and their use as kinase inhibitors
    Patent number: 8916577
    Abstract: New substituted tricyclic compounds of formula (I) are described, wherein R1, R2, X, Y, Z are herein defined, having protein kinase inhibiting activity. The invention includes methods to prepare the compounds of formula (I), pharmaceutical compositions containing them, and their use in therapy, in particular for the treatment of diseases caused by and/or associated with dysregulated activity of protein kinase.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: December 23, 2014
    Assignee: Nerviano Medical Sciences S.R.L.
    Inventors: Marina Caldarelli, Francesco Casuscelli, Daniele Donati, Danilo Mirizzi, Francesca Quartieri, Marco Silvagni
  • N-aryl-2-(2-arylaminopyrimidin-4-yl)pyrrol-4-carboxamide derivatives as MPS1 kinase inhibitors
    Patent number: 8772280
    Abstract: The present invention relates to substituted pyrrolyl-pyrimidines which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular MPS1. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: July 8, 2014
    Assignee: Nerviano Medical Sciences S.R.L.
    Inventors: Marina Caldarelli, Stefano Adele Nuvoloni, Francesca Quartieri