Patents by Inventor Francesca R. Salipur

Francesca R. Salipur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for modulating DNMT1 inhibitor activity
    Patent number: 9737493
    Abstract: Some aspects of the invention include attenuating DNMT1 inhibitor activity in an animal comprising administering an antioxidant. Other aspects of the invention include methods comprising administering a composition comprising a DNMT1 inhibitor and an antioxidant. In some instances in the methods, the animal is undergoing a treatment for cancer. Additional aspects of the invention include compositions comprising a DNMT1 inhibitor and an antioxidant.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: August 22, 2017
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Francesca R. Salipur, Paula J. Bates, Elsa Merit Reyes-Reyes, Bo Xu, Gerald B. Hammond
  • Predictive marker of DNMT1 inhibitor therapeutic efficacy and methods of using the marker
    Patent number: 9383364
    Abstract: Provided herein are methods for predicting efficacy of a DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibitor treatment in a subject having a cancer, methods of identifying a subject having a cancer that is more likely to respond to a DNMT1 inhibitor treatment, and methods of selecting a treatment for a subject having a cancer that include determining a level of SOX9 in a sample containing cells from a subject having a cancer. Also provided are methods of treating a subject having a cancer that include selectively administering a DNMT1 inhibitor to a subject having cancer determined to have an elevated level of SOX9 in a sample containing cells from the subject compared to a reference level. Also provided are antibodies and antigen-binding antibody fragments that specifically bind to SOX9, and nucleic acid sequences that contain at least 10 nucleotides complementary to a contiguous sequence present in a SOX9 nucleic acid for use in these methods.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: July 5, 2016
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Paula J. Bates, Mohammad Tariq Malik, Francesca R. Salipur
  • COMPOSITIONS AND METHODS FOR MODULATING DNMT1 INHIBITOR ACTIVITY
    Publication number: 20150238439
    Abstract: Some aspects of the invention include attenuating DNMT1 inhibitor activity in an animal comprising administering an antioxidant. Other aspects of the invention include methods comprising administering a composition comprising a DNMT1 inhibitor and an antioxidant. In some instances in the methods, the animal is undergoing a treatment for cancer. Additional aspects of the invention include compositions comprising a DNMT1 inhibitor and an antioxidant.
    Type: Application
    Filed: September 6, 2013
    Publication date: August 27, 2015
    Inventors: Francesca R. Salipur, Paula J. Bates, Elsa Merit Reyes-Reyes, Bo Xu, Gerald B. Hammond
  • PREDICTIVE MARKER OF DNMT1 INHIBITOR THERAPEUTIC EFFICACY AND METHODS OF USING THE MARKER
    Publication number: 20140329911
    Abstract: Provided herein are methods for predicting efficacy of a DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibitor treatment in a subject having a cancer, methods of identifying a subject having a cancer that is more likely to respond to a DNMT1 inhibitor treatment, and methods of selecting a treatment for a subject having a cancer that include determining a level of SOX9 in a sample containing cells from a subject having a cancer. Also provided are methods of treating a subject having a cancer that include selectively administering a DNMT1 inhibitor to a subject having cancer determined to have an elevated level of SOX9 in a sample containing cells from the subject compared to a reference level. Also provided are antibodies and antigen-binding antibody fragments that specifically bind to SOX9, and nucleic acid sequences that contain at least 10 nucleotides complementary to a contiguous sequence present in a SOX9 nucleic acid for use in these methods.
    Type: Application
    Filed: March 7, 2012
    Publication date: November 6, 2014
    Applicant: University of Louisville Research Foundation, Inc.
    Inventors: Paula J. Bates, Mohammad Tariq Malik, Francesca R. Salipur