Patents by Inventor Francesco Belardetti

Francesco Belardetti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic pyrimidine derivatives as calcium channel blockers
    Patent number: 8133998
    Abstract: Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing thienopyrimidine or oxoquinazoline derivatives are disclosed of the general formula (1) or formula (2) where X is a linker and Y is an aromatic moiety or N(R5)(R6).
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: March 13, 2012
    Assignee: Zalicus Pharmaceuticals, Ltd.
    Inventors: Hassan Pajouhesh, Hossein Pajouhesh, Yanbing Ding, Jason Tan, Mike Grimwood, Francesco Belardetti, Ramesh Kaul, Richard Holland, Navjot Chahal
  • Diamine calcium channel blockers
    Patent number: 7511077
    Abstract: Aromatic derivatives of aliphatic diamines are effective in ameliorating conditions characterized by unwanted calcium ion channel activity, especially T-type and N-type channels. These conditions include, for example, stroke and pain.
    Type: Grant
    Filed: February 8, 2006
    Date of Patent: March 31, 2009
    Assignee: Neuromed Pharmaceuticals Ltd.
    Inventors: Hassan Pajouhesh, Hossein Pajouhesh, Yanbing Ding, Terrance P. Snutch, Francesco Belardetti
  • BICYCLIC PYRIMIDINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS
    Publication number: 20080280900
    Abstract: Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing thienopyrimidine or oxoquinazoline derivatives are disclosed of the general formula (1) or formula (2) where X is a linker and Y is an aromatic moiety or N(R5)(R6).
    Type: Application
    Filed: May 9, 2008
    Publication date: November 13, 2008
    Inventors: Hassan PAJOUHESH, Hossein PAJOUHESH, Yanbing DING, Jason TAN, Mike GRIMWOOD, Francesco BELARDETTI, Ramesh KAUL
  • AMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS
    Publication number: 20080227823
    Abstract: Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing both a diamide and aromatic functionality are disclosed of the general formula (1) where X1 and X2 are linkers.
    Type: Application
    Filed: March 4, 2008
    Publication date: September 18, 2008
    Inventors: Hassan Pajouhesh, Nagasree Chakka, Yuanxi Zhou, Francesco Belardetti
  • Fluorescence based T-type channel assay
    Patent number: 7270949
    Abstract: A fluorescence based assay for compounds that modulate T-type calcium ion channels and that can be adapted to high throughput screening formats. Modulators of T-type channels are useful to correct functional abnormalities. These abnormalities are associated with epilepsy, pain, schizophrenia, depression, anxiety, cardiac arrhythmia, hypertension, certain types of cancer, diabetes, infertility, sexual dysfunction and other undesirable conditions.
    Type: Grant
    Filed: January 7, 2004
    Date of Patent: September 18, 2007
    Assignee: Neuromed Pharmaceuticals Ltd.
    Inventors: Francesco Belardetti, Diana Janke, David Parker, Terrance P. Snutch
  • Preferentially substituted calcium channel blockers
    Patent number: 7186726
    Abstract: Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
    Type: Grant
    Filed: September 3, 2003
    Date of Patent: March 6, 2007
    Assignee: Neuromed Pharmaceuticals Ltd.
    Inventors: Terrance P. Snutch, Gerald W. Zamponi, Hassan Pajouhesh, Hossein Pajouhesh, Francesco Belardetti
  • Diamine calcium channel blockers
    Publication number: 20060235050
    Abstract: Aromatic derivatives of aliphatic diamines are effective in ameliorating conditions characterized by unwanted calcium ion channel activity, especially T-type and N-type channels. These conditions include, for example, stroke and pain.
    Type: Application
    Filed: February 8, 2006
    Publication date: October 19, 2006
    Applicant: Nueromed Technologies, Inc.
    Inventors: Hassan Pajouhesh, Hossein Pajouhesh, Yanbing Ding, Terrance Snutch, Francesco Belardetti
  • Calcium channel blockers comprising two benzhydril moieties
    Publication number: 20060084660
    Abstract: Certain piperazine compounds are described which are useful in altering calcium channel activity.
    Type: Application
    Filed: August 29, 2005
    Publication date: April 20, 2006
    Inventors: Terrance Snutch, Gerald Zamponi, Hassan Pajouhesh, Hossein Pajouhesh, Francesco Belardetti
  • Calcium channel blockers comprising two benzhydril moieties
    Patent number: 6951862
    Abstract: Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: October 4, 2005
    Assignee: Neuromed Technologies, Inc.
    Inventors: Terrance P. Snutch, Gerald W. Zamponi, Hassan Pajouhesh, Hossein Pajouhesh, Francesco Belardetti
  • Calcium channel blockers comprising two benzhydril moieties
    Patent number: 6949554
    Abstract: Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: September 27, 2005
    Assignee: NeuroMed Technologies Inc.
    Inventors: Terrance P. Snutch, Gerald W. Zamponi, Hassan Pajouhesh, Hossein Pajouhesh, Francesco Belardetti
  • Calcium channel inhibitors comprising benzhydril spaced from piperazine
    Patent number: 6943168
    Abstract: Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: September 13, 2005
    Assignee: NeuroMED Technologies Inc.
    Inventors: Terrance P. Snutch, Gerald W. Zamponi, Hassan Pajouhesh, Hossein Pajouhesh, Francesco Belardetti
  • Calcium channel inhibitors comprising benzhydril spaced from piperazine
    Publication number: 20040266784
    Abstract: Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
    Type: Application
    Filed: April 9, 2004
    Publication date: December 30, 2004
    Inventors: Terrance P. Snutch, Gerald W. Zamponi, Hassan Pajouhesh, Francesco Belardetti, Hossein Pajouhesh
  • Calcium channel blockers comprising two benzhydril moieties
    Publication number: 20040259866
    Abstract: Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
    Type: Application
    Filed: April 9, 2004
    Publication date: December 23, 2004
    Inventors: Terrance P. Snutch, Gerald W. Zamponi, Hassan Pajouhesh, Francesco Belardetti, Hossein Pajouhesh
  • Calcium channel blockers comprising two benzhydril moieties
    Publication number: 20040209872
    Abstract: Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
    Type: Application
    Filed: December 23, 2003
    Publication date: October 21, 2004
    Inventors: Terrance P. Snutch, Gerald W. Zamponi, Hassan Pajouhesh, Hossein Pajouhesh, Francesco Belardetti
  • Fluorescence based T-type channel assay
    Publication number: 20040180323
    Abstract: A fluorescence based assay for compounds that modulate T-type calcium ion channels and that can be adapted to high throughput screening formats. Modulators of T-type channels are useful to correct functional abnormalities. These abnormalities are associated with epilepsy, pain, schizophrenia, depression, anxiety, cardiac arrhythmia, hypertension, certain types of cancer, diabetes, infertility, sexual dysfunction and other undesirable conditions.
    Type: Application
    Filed: January 7, 2004
    Publication date: September 16, 2004
    Inventors: Francesco Belardetti, Diana Janke, David Parker, Terrance P. Snutch
  • Preferentially substituted calcium channel blockers
    Publication number: 20040147529
    Abstract: Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
    Type: Application
    Filed: September 3, 2003
    Publication date: July 29, 2004
    Inventors: Terrance P. Snutch, Gerald W. Zamponi, Hassan Pajouhesh, Hossein Pajouhesh, Francesco Belardetti
  • Calcium channel inhibitors comprising benzhydril spaced from piperazine
    Publication number: 20040044004
    Abstract: Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
    Type: Application
    Filed: April 8, 2003
    Publication date: March 4, 2004
    Applicant: NeuroMed Technologies, Inc.
    Inventors: Terrance P. Snutch, Gerald W. Zamponi, Hassan Pajouhesh, Hossein Pajouhesh, Francesco Belardetti
  • Calcium channel inhibitors comprising benzhydril spaced from piperazine
    Publication number: 20040034035
    Abstract: Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
    Type: Application
    Filed: April 8, 2003
    Publication date: February 19, 2004
    Applicant: NeuroMed technologies, Inc.
    Inventors: Terrance P. Snutch, Gerald W. Zamponi, Hassan Pajouhesh, Hossein Pajouhesh, Francesco Belardetti