Patents by Inventor Francesco De Angelis

Francesco De Angelis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240061615
    Abstract: Methods, systems, and devices for command scheduling for a memory system are described. A memory system may be configured to analyze a received command during an initialization procedure for one or more components. In some examples, the memory system may initialize an interface and one or more processing elements as part of an initialization procedure upon transitioning from a first power mode to a second power mode. Accordingly, the command may be analyzed while the processing elements are being initialized such that, upon the processing elements being fully initialized, the command may be processed (e.g., executed).
    Type: Application
    Filed: August 22, 2022
    Publication date: February 22, 2024
    Inventors: Domenico Francesco De Angelis, Crescenzo Attanasio, Carminantonio Manganelli
  • Patent number: 11624744
    Abstract: A method of recording intracellular action potentials in electrogenic cells through pores in membranes of cells formed by optoporation includes positioning a sample that includes the cells on a multi-electrode array; incubating or perfusing the sample; focusing a laser on the surface of the array electrodes, the surface contacting the sample; applying one or more laser pulses to one or more array electrodes to perform a localized breakdown of the membrane of the cells of the sample; and recording the intracellular action potentials. The surface of the electrodes is porous and has cavities and protrusions at the nanoscale level, and the electric field produced by the laser is localized and amplified to perform the localized breakdown of the membrane of the cells of the sample.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: April 11, 2023
    Inventors: Francesco De Angelis, Michele Dipalo
  • Publication number: 20230060283
    Abstract: A microfluidic device comprises a lower layer that is electrically conductive and transparent with respect to an incident optical beam, an upper layer, comprising first portions that are electrically conductive and second portions that are electrically insulating, adjacent and alternated to the first ones; a compartment interposed between the lower layer and the upper layer seamlessly extending between the lower layer and the upper layer; the compartment contains a filler medium that is transparent with respect to the incident optical beam and markers dispersed in the filler medium; the markers are electrically charged and are adapted to move inside the compartment in all directions in variable amounts according to the intensity of the electrical signal applied and to emit an optical emission beam when lit by an incident optical beam.
    Type: Application
    Filed: January 21, 2021
    Publication date: March 2, 2023
    Inventors: Francesco DE ANGELIS, Michele DIPALO, Francesco TANTUSSI, Andrea BARBAGLIA, Andrea TOMA
  • Publication number: 20230051647
    Abstract: A microfluidic device comprises a lower layer that is electrically conductive and transparent with respect to an incident optical beam, an upper layer, comprising first portions that are electrically conductive and second portions that are electrically insulating, adjacent and alternated to the first ones; a compartment seamlessly extending between the lower layer and the upper layer; the compartment contains a filler medium configured to emit an optical emission beam and markers dispersed in the filler medium, which are electrically charged and are adapted to move inside the compartment in all directions according to the intensity of the electrical signal applied to the first portions, the filler medium is configured to interact with the markers to increase or decrease the intensity of the optical emission beam according to the local concentration of the markers.
    Type: Application
    Filed: January 21, 2021
    Publication date: February 16, 2023
    Inventors: Francesco DE ANGELIS, Michele DIPALO, Francesco TANTUSSI, Andrea BARBAGLIA, Andrea TOMA
  • Publication number: 20220032296
    Abstract: A microfluidic device comprises electrically conductive lower portions, transparent to an incident optical beam; first upper portions electrically conductive and configured to receive an electrical signal; shielding portions opaque to the incident optical beam and arranged between the first upper portions and the lower portions, the shielding portions having one or more through openings; one or more compartments containing a filler means and markers dispersed in filler means. Each compartment comprises at least one lower chamber and at least one upper chamber in fluid communication with each other via said one or more through openings. Each lower chamber extends between a respective through opening and the lower portions and each upper chamber extends between at least one respective through opening and the first upper portions.
    Type: Application
    Filed: September 17, 2019
    Publication date: February 3, 2022
    Inventors: Francesco DE ANGELIS, Andrea BARBAGLIA, Michele DIPALO, Francesco TANTUSSI
  • Publication number: 20200355670
    Abstract: A method of recording intracellular action potentials in electrogenic cells through pores in membranes of cells formed by optoporation includes positioning a sample that includes the cells on a multi-electrode array; incubating or perfusing the sample; focusing a laser on the surface of the array electrodes, the surface contacting the sample; applying one or more laser pulses to one or more array electrodes to perform a localized breakdown of the membrane of the cells of the sample; and recording the intracellular action potentials. The surface of the electrodes is porous and has cavities and protrusions at the nanoscale level, and the electric field produced by the laser is localized and amplified to perform the localized breakdown of the membrane of the cells of the sample.
    Type: Application
    Filed: December 12, 2018
    Publication date: November 12, 2020
    Inventors: Francesco De Angelis, Michele Dipalo
  • Publication number: 20180261838
    Abstract: Carbon doped TiO2—Bronze nanostructures, preferably nanowires were synthesized via a facile doping mechanism and were exploited as active material for Li-ion batteries. Both the wire geometry and the presence of carbon doping contribute to high electrochemical performance of these materials. Direct carbon doping for example reduces the Li-ion diffusion length and improves the electrical conductivity of the wires, as demonstrated by cycling experiments, which evidenced remarkably higher capacities and superior rate capability over the undoped nanowires. The as prepared carbon-doped nanowires, evaluated in lithium half-cells, exhibited lithium storage capacity of ˜306 mA h g?1 (91% of the theoretical capacity) at the current rate of 0.1C as well as excellent discharge capacity of ˜160 mAh g?1 even at the current rate of 10C after 1000 charge/discharge cycles.
    Type: Application
    Filed: October 7, 2016
    Publication date: September 13, 2018
    Inventors: Claudio CAPIGLIA, Remo PROIETTI ZACCARIA, Subrahmanyam GORIPARTI, Ermanno MIELE, Francesco DE ANGELIS
  • Patent number: 9067242
    Abstract: Methods are provided for obtaining hollow nano-structures which include the steps of providing a suspended film starting layer on a support substrate, depositing on the starting layer a sacrificial layer, performing, in progressive sequence, a complete erosion phase of said support substrate and starting layer and performing an at least partial erosion phase of the sacrificial layer previously deposited on the starting layer so as to obtain holes passing through the starting layer and passing or non passing through the sacrificial layer, depositing, on the side of the support substrate opposite to that where the starting layer is put, at least one covering layer arranged to internally cover the holes created by the progressive erosion. Hollow nano-structures formed by such methods are also provided.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: June 30, 2015
    Assignee: Fondazione Istituto Italiano di Tecnologia
    Inventors: Francesco De Angelis, Enzo Di Fabrizio
  • Patent number: 8749777
    Abstract: Concentrator and locator device (1) of a solute comprising a substrate (2) and a plurality of prismatic lithographic micro-structures (4) orthogonally emerging from the substrate (2). The microstructures (4) are spaced from one another in a periodical manner so as to make such a substrate (2) super-hydrophobic.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: June 10, 2014
    Assignee: Calmed S.r.l.
    Inventors: Enzo Mario Di Fabrizio, Giovanni Cuda, Federico Mecarini, Francesco De Angelis, Francesco Gentile
  • Publication number: 20130284696
    Abstract: Methods are provided for obtaining hollow nano-structures which include the steps of providing a suspended film starting layer on a support substrate, depositing on the starting layer a sacrificial layer, performing, in progressive sequence, a complete erosion phase of said support substrate and starting layer and performing an at least partial erosion phase of the sacrificial layer previously deposited on the starting layer so as to obtain holes passing through the starting layer and passing or non passing through the sacrificial layer, depositing, on the side of the support substrate opposite to that where the starting layer is put, at least one covering layer arranged to internally cover the holes created by the progressive erosion. Hollow nano-structures formed by such methods are also provided.
    Type: Application
    Filed: January 26, 2012
    Publication date: October 31, 2013
    Applicant: Fondazione Istituto Italiano di Tecnologia
    Inventors: Francesco De Angelis, Enzo Di Fabrizio
  • Publication number: 20120045578
    Abstract: A method for manufacturing a photonic crystal device provided with a plasmonic waveguide includes: preparing a membrane; applying, in a programmed manner, a focused ion beam on the membrane, in a manner such as to obtain a photonic crystal made up by a regular planar arrangement of through holes positioned according to a preset lattice and also comprising a resonant cavity. The method also provides a conic plasmonic waveguide at the resonant cavity, through chemical vapour deposition induced by a focused electron beam. The focused electron beam that induces la deposition is controlled in such a manner to gradually reduce the transverse section of the electron beam starting from the base up to the tip of the projecting structure, maintaining the position of the electron beam constant.
    Type: Application
    Filed: September 22, 2009
    Publication date: February 23, 2012
    Applicant: CALMED S.r.l.
    Inventors: Enzo Mario Di Fabrizio, Francesco De Angelis, Gobind Das, Federico Mecarini, Patrizio Candeloro, Carlo Liberale
  • Publication number: 20110265305
    Abstract: Method for manufacturing an optical detection device includes producing metal nanospheres on a substrate (2). The process also includes the following operations: producing (100) on the substrate (2) lithographic nanostructures (4a, 4b, 4c) capable of receiving the metal nanospheres,—performing (102) a self-aggregative deposition of at least one metal in such a way as to create a respective metal nanosphere in each lithographic nanostructure (4a, 4b, 4c).
    Type: Application
    Filed: December 31, 2009
    Publication date: November 3, 2011
    Applicant: CALMED S.r.l.
    Inventors: Enzo Mario Di Fabrizio, Maria Laura Coluccio, Federico Mecarini, Francesco De Angelis, Gobind Das, Patrizio Candeloro, Giovanni Cuda
  • Publication number: 20110188037
    Abstract: Concentrator and locator device (1) of a solute comprising a substrate (2) and a plurality of prismatic lithographic micro-structures (4) orthogonally emerging from the substrate (2). The microstructures (4) are spaced from one another in a periodical manner so as to make such a substrate (2) super-hydrophobic.
    Type: Application
    Filed: August 28, 2009
    Publication date: August 4, 2011
    Applicant: CALMED S.R.L.
    Inventors: Enzo Mario Di Fabrizio, Giovanni Cuda, Federico Mecarini, Francesco De Angelis, Francesco Gentile
  • Patent number: 6822115
    Abstract: R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives are prepared using starting from aspartic acid with the same configuration as the desired compounds. This process is advantageous from the industrial point of view in terms of the type of reactants used, the reduced volumes of solvents and the possibility of avoiding purification of the intermediate products.
    Type: Grant
    Filed: February 25, 2003
    Date of Patent: November 23, 2004
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Natalina Dell'uomo, Maria Ornella Tinti, Francesco De Angelis
  • Publication number: 20030153783
    Abstract: A process is described for the preparation of R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives with the following formula: 1
    Type: Application
    Filed: January 8, 2003
    Publication date: August 14, 2003
    Applicant: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Natalina Dell'Uomo, Maria Ornella Tinti, Francesco De Angelis
  • Publication number: 20030153784
    Abstract: A process is described for the preparation of R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives with the following formula: 1
    Type: Application
    Filed: February 25, 2003
    Publication date: August 14, 2003
    Inventors: Fabio Giannessi, Natalina Dell'uomo, Maria Ornella Tinti, Francesco De Angelis
  • Patent number: 6528684
    Abstract: R or S aminocarnitine and their derivatives with formula (I) where Y is as described in the description, starting with aspartic acid with the same configuration as the aminocarnitine desired. This process has advantage in the type of reactants used, reduced volumes of solvents and the possibility of avoiding purification of intermediate products.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: March 4, 2003
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Natalina Dell'uomo, Maria Ornella Tinti, Francesco De Angelis
  • Patent number: 6444701
    Abstract: Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medicaments useful in the pathologies related to a hyperactivity of carnitine palmitoyl-transferase, such as hyperglycemia, diabetes and pathologies related thereto, heart failure, ischemia.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: September 3, 2002
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Mauro Marzi, Patrizia Minetti, Francesco De Angelis, Maria Ornella Tinti, Piero Chiodi, Arduino Arduini
  • Patent number: RE40861
    Abstract: Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medicaments useful in the pathologies related to a hyperactivity of carnitine palmitoyl-transferase, such as hyperglycemia, diabetes and pathologies related thereto, heart failure, ischemia.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: July 21, 2009
    Assignee: Sigma-Tau Industrie Farmaceutiche Reunite S.p.A.
    Inventors: Fabio Giannessi, Mauro Marzi, Patrizia Minetti, Francesco De Angelis, Maria O. Tinti, Piero Chiodi, Arduino Arduini
  • Patent number: RE41226
    Abstract: Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medicaments useful in the pathologies related to a hyperactivity of carnitine polymitoyl-transferase, such as hyperglycemia, diabetes and pathologies related thereto, heart failure, ischemia.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: April 13, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Mauro Marzi, Patrizia Minetti, Francesco De Angelis, Maria Ornella Tinti, Piero Chiodi, Arduino Arduini