Abstract: The present disclosure relates generally to methods and apparatus to control delivery of a sealant during an invasive procedure. Disclosed methods and apparatus control movement of a syringe to control injection of sealant stored therein. For example, disclosed methods and apparatus can displace the syringe body relative to the plunger as the syringe is withdrawn from the target site, rather than displacing the plunger relative to the syringe body, to thereby pressurize the sealant or inject the sealant in an amount proportional to a distance the syringe body is withdrawn. This reduces the variability in the amount of sealant delivered along the syringe withdrawal pathway. The disclosed methods and apparatus can increase precision in movement of a syringe, thereby increasing precision in sealant delivery.

Abstract: An implantable and/or injectable device made of biodegradable material which comprises two hollow volumes where said device comprises a cylinder, which comprises a top portion and a bottom portion, where the top end and bottom end of said cylinder are open and via said openings on said top and bottom ends a first hollow volume and a second hollow volume are respectively accessed, where said first hollow volume and second hollow volume are separated from each other by a partition and are characterized in that the side wall of said first hollow volume has a thickness which is smaller than the thickness of the side wall of said second hollow volume. A method for manufacturing, filling with at least one active agent and closing said device and the use of the said device filled with at least one active agent for the treatment and/or the prevention of pathologies which require repeated and programmed administration over time.