Patents by Inventor Francesco De Santis

Francesco De Santis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glycosaminoglycan salts and pharmaceutical compositions containing them
    Patent number: 5264425
    Abstract: Salts of glycosaminoglycans (heparin, its fractions or fragments which are supersulfated, dermatan sulfate, heparan sulfate, and modified heparins) with bases of formula (I), ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 represent H, alkyl, or cycloalkyl; R.sub.5 and R.sub.6 represent H, or alkyl; R.sub.7 and R.sub.8 represent H or alkyl; n and m are integers from 1-4 and X is --O--CO--O--, which salts have the pharmacological properties of the glycosaminoglycans themselves, and are orally and rectally administrable.
    Type: Grant
    Filed: November 15, 1990
    Date of Patent: November 23, 1993
    Assignee: Italfarmaco S.p.A.
    Inventors: Alma Dal Pozzo, Maurizio Acquasaliente, Giancarlo Sportoletti, Monique Sarret, Paolo Ferruti, Francesco De Santis
  • Process for preparing EDTA-free heparins, heparin fractions and fragments
    Patent number: 5110918
    Abstract: Heparins, heparin fractions or fragments, optionally salified with pharmaceutically acceptable cations, having molecular weight ranging from 1.000 to 30.000 D, characterized by an EDTA content lower than 0.1%, by the absence, in the .sup.1 H--NMR spectra, of the signals due to EDTA between 2.50 and 4.00 p.p.m. and substantially free from bleeding effect and optionally free from signals, in the .sup.13 C--NMR spectrum, from 80 to 86 ppm.
    Type: Grant
    Filed: September 24, 1990
    Date of Patent: May 5, 1992
    Assignee: Sanofi S.A.
    Inventors: Benito Casu, Annamaria Naggi, Pasqua Oreste, Giangiacomo Torri, Giorgio Zoppetti, Giancarlo Sportoletti, Francesco De Santis