Abstract: There is described a genome editing system, more particularly a dual vector CRISPR-Cas system suitable for gene editing-mediated correction of a mutant genomic target sequence in a target cell. There are further described a set of two viral particles and a host eukaryotic cell comprising the CRISPR-Cas system of the invention as well as the therapeutic use of this system, particularly for the treatment of genetic diseases.

Abstract: A CRISPR-Cas system targeting a genomic target sequence in a eukaryotic cell and capable of promoting death of the eukaryotic cell is provided. A viral particle and an isolated eukaryotic cell including the CRISPR-Cas system, a method that uses the CRISPR-Cas system, and use of the CRISPR-Cas system as a medicament in the treatment of neoplastic diseases are also provided.

Abstract: A reflecting parabolic construction for solar heating systems comprises at least a reflecting parabola for concentrating solar beams on a thermal carrier containing receiver tube, wherein the parabola comprises an aluminum fretted central layer, on the faces thereof two opposite aluminum layers are applied. According to a first embodiment, in the concave part of the reflecting parabolic construction a crystal mirror of minimum thickness is applied. According to a further aspect of the invention, one of the layers is a reflecting aluminum layer made by depositing vapors, and protected by a sol-gel protective layer having a thickness corresponding to few microns.

Abstract: A telemetry system for bi-directional communication of data between a well point and a terminal unit situated on a surface, which can be used inside drilling or production strings. The system includes data transmission and optional reception devices. An active vehicle, which can be equipped with plural automation levels, ranging from purely tele-operated to completely autonomous, is provided for unwinding and pulling a connection line, capable of moving inside a drilling or production string, or a passive vehicle, moved by a deploying cable and a suitable winding/unwinding device, in particular a winch. A connection line, containing electric conductors and/or one or more optical fibers of the transmission and optional reception devices is provided between a well point and its corresponding point situated inside the vehicle or on the surface.

Abstract: A telemetry system for bi-directional communication of data between a well point and a terminal unit situated on a surface, which can be used inside drilling or production strings. The system includes data transmission and optional reception devices. An active vehicle, which can be equipped with plural automation levels, ranging from purely tele-operated to completely autonomous, is provided for unwinding and pulling a connection line, capable of moving inside a drilling or production string, or a passive vehicle, moved by a deploying cable and a suitable winding/unwinding device, in particular a winch. A connection line, containing electric conductors and/or one or more optical fibers of the transmission and optional reception devices is provided between a well point and its corresponding point situated inside the vehicle or on the surface.

Abstract: An underwater sub-surface safety valve block is connected between a well head located at the sea bottom, and the lower end of a riser. This allows the production tube and/or the service tube of the completion string to be closed by means of gate valves. This sub-surface safety valve block comprises a valve body provided with a vertical through-bore tightly closed at its upper end by a packer to which the upper portion of the completion string is connected. The bottom is tightly closed by a tubing hanger to which the lower portion of the completion string is connected. The packer and the tubing hanger are fastened inside the through-bore by means of a mechanical hooking which can be disengaged by means of a hydraulic controlled action. They are each provided with a through-channel in order to connect the respective production tubes with the central region of the through-bore, which can be closed by means of a gate valve.