Abstract: Vitrectomy probe (1) for the removal of the vitreous humour (1a) and comprising a tube (2) adapted to be put into direct contact with the vitreous (1a), defining a main axis (2a) and including an internal passage (21) and a opening (23) enabling the vitreous (1a) to enter the internal passage (21) and comprising at least one cutting edge (23a, 23b); a suction system suitable for the creation of vacuum within the internal passage (21) sucking the vitreous (1a) into the opening (23); a drive unit adapted to move the tube (2) defining a vibrational motion (A) of the tube (2) which therefore produces pressure waves reducing the viscosity of the vitreous (1a), and a reciprocating motion (B), having a frequency lower than the frequency of the vibrational motion (A), adapted to enable the cutting edges (23a, 23b) to cut the vitreous (1a)