Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to a class of monoalkylated cyanine dyes with red to near-infrared (650-900 nm) emission characterized by pH responsiveness and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them. The monoalkylated cyanine dyes have general formula (I) wherein R1 and R3 are independently selected from the group consisting of hydrogen, -SO3H, —COOH and —CONH—Y; and R2 and R4 are hydrogen, or both R1 together with R2 and R3 together with R4, respectively and with the atoms to which they are bonded, form two aryl rings, optionally substituted with from 1 to 4 -SO3H groups; R5 is an alkyl optionally substituted by a group selected from —SO3H, —COOH and —CONH2.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a direct-lit backlight unit. The backlight unit may include an array of light-emitting diodes (LEDs) on a printed circuit board. The display may have a notch to accommodate an input-output component. Reflective layers may be included in the notch. The backlight may include a color conversion layer with a property that varies as a function of position. The light-emitting diodes may be covered by a slab of encapsulant with recesses in an upper surface.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a direct-lit backlight unit. The backlight unit may include an array of light-emitting diodes (LEDs) on a printed circuit board. The display may have a notch to accommodate an input-output component. Reflective layers may be included in the notch. The backlight may include a color conversion layer with a property that varies as a function of position. The light-emitting diodes may be covered by a slab of encapsulant with recesses in an upper surface.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a direct-lit backlight unit. The backlight unit may include an array of light-emitting diodes (LEDs) on a printed circuit board. The display may have a notch to accommodate an input-output component. Reflective layers may be included in the notch. The backlight may include a color conversion layer with a property that varies as a function of position. The light-emitting diodes may be covered by a slab of encapsulant with recesses in an upper surface.

Abstract: An electronic device includes an enclosure formed of a plurality of layers cooperating to define an interior volume. The enclosure includes a first layer formed of a first material and defining a user input surface of the enclosure and a first portion of a side surface of the enclosure. The enclosure also includes a second layer, formed of a second material different from the first material, positioned below the first layer and defining a second portion of the side surface of the enclosure. The enclosure also includes a third layer, formed of a third material different from the first and second materials, positioned below the second layer and defining a bottom surface of the enclosure and a third portion of the side surface of the enclosure.

Abstract: Disclosed are methods or processes of synthesizing building blocks and feedstocks for producing a broader range of polymers, including renewable polymers, from renewable resources such as CO2. In a process of manufacturing a renewable feedstock for polymer production, a CO2 derived lactone is prepared and processed to form the renewable feedstock. The process may include alkoxycarbonylation of the CO2 derived lactone to form a diester and hydrogenation of the diester.

Abstract: Disclosed are methods or processes of synthesizing building blocks and feedstocks for producing a broader range of polymers, including renewable polymers, from renewable resources such as CO2. In a process of manufacturing a renewable feedstock for polymer production, a CO2 derived lactone is prepared and processed to form the renewable feedstock. The process may include alkoxycarbonylation of the CO2 derived lactone to form a diester and hydrogenation of the diester.

Abstract: An electronic device includes an enclosure formed of a plurality of layers cooperating to define an interior volume. The enclosure includes a first layer formed of a first material and defining a user input surface of the enclosure and a first portion of a side surface of the enclosure. The enclosure also includes a second layer, formed of a second material different from the first material, positioned below the first layer and defining a second portion of the side surface of the enclosure. The enclosure also includes a third layer, formed of a third material different from the first and second materials, positioned below the second layer and defining a bottom surface of the enclosure and a third portion of the side surface of the enclosure.

Abstract: An electronic device includes an enclosure formed of a plurality of layers cooperating to define an interior volume. The enclosure includes a first layer formed of a first material and defining a user input surface of the enclosure and a first portion of a side surface of the enclosure. The enclosure also includes a second layer, formed of a second material different from the first material, positioned below the first layer and defining a second portion of the side surface of the enclosure. The enclosure also includes a third layer, formed of a third material different from the first and second materials, positioned below the second layer and defining a bottom surface of the enclosure and a third portion of the side surface of the enclosure.

Abstract: An electronic device can include a frame configured to receive and support an electronic component, a shell defining an internal volume sized to encompass the frame and the electronic component, the shell being slidably removable from the frame, the electronic component positioned within the internal volume and including an aperture, and a sealing member including a seal body and a compressible lip extending from the seal body, the sealing member at least partially surrounding the electronic component. The compressible lip is oriented such that the shell compresses the lip in a direction against the seal body at a first position adjacent to the electronic component and in the direction against the seal body at a second position adjacent to the electronic component opposite the first position.

Abstract: The metal-catalyzed alkoxycarbonylation of a lactone is a method of alkoxycarbonylating a ?-lactone, specifically 3-ethylidene-6-vinyltetrahydro-2H-pyran-2-one. The method includes combining the ?-lactone with an alcohol in an organic solvent in the presence of a catalyst system that includes palladium or a salt thereof to form a reaction mixture, which is heated to 110-130° C. at a pressure of 20-50 bar for between 3-5 hours under flow of carbon monoxide gas. The product of the reaction is a substituted 2-octendioate diester. The alcohol may be methyl alcohol, n-butyl alcohol, 2-ethylhexanol, isobutyl alcohol, isopropyl alcohol, benzyl alcohol, or phenol. The solvent may be toluene, acetonitrile, or tetrahydrofuran. The method may include adding an acid to the reaction mixture, which may be dilute (about 5 mol %) sulfuric or p-toluenesulfonic acid. The catalyst system may also include a phosphine ligand.

Abstract: An electronic device includes an enclosure formed of a plurality of layers cooperating to define an interior volume. The enclosure includes a first layer formed of a first material and defining a user input surface of the enclosure and a first portion of a side surface of the enclosure. The enclosure also includes a second layer, formed of a second material different from the first material, positioned below the first layer and defining a second portion of the side surface of the enclosure. The enclosure also includes a third layer, formed of a third material different from the first and second materials, positioned below the second layer and defining a bottom surface of the enclosure and a third portion of the side surface of the enclosure.

Abstract: The metal-catalyzed alkoxycarbonylation of a lactone is a method of alkoxycarbonylating a ?-lactone, specifically 3-ethylidene-6-vinyltetrahydro-2H-pyran-2-one. The method includes combining the ?-lactone with an alcohol in an organic solvent in the presence of a catalyst system that includes palladium or a salt thereof to form a reaction mixture, which is heated to 110-130° C. at a pressure of 20-50 bar for between 3-5 hours under flow of carbon monoxide gas. The product of the reaction is a substituted 2-octendioate diester. The alcohol may be methyl alcohol, n-butyl alcohol, 2-ethylhexanol, isobutyl alcohol, isopropyl alcohol, benzyl alcohol, or phenol. The solvent may be toluene, acetonitrile, or tetrahydrofuran. The method may include adding an acid to the reaction mixture, which may be dilute (about 5 mol %) sulfuric or p-toluenesulfonic acid. The catalyst system may also include a phosphine ligand.

Abstract: The eyeglass frames with detachable temple pieces are similar in form and function to conventional eyeglass frames, but are configured to enable one or more temple pieces or components to be removably attached to the eyewear frame, and further to be interchanged with other detachable temple pieces as desired. This interchangeability permits a user to change the temple piece in the event of breakage, or for purposes of changing the style and appearance of the eyeglass frame. The eyeglass frames with detachable temple pieces include a front eyewear frame having a pair of opposed side ends and a pair of temple pieces respectively, releasably and pivotally secured to the side ends of the front eyewear frame. A bridge cover is preferably provided for releasably covering a bridge of the front eyewear frame.

Abstract: The eyeglass frames with detachable temple pieces are similar in form and function to conventional eyeglass frames, but are configured to enable one or more temple pieces or components to be removably attached to the eyewear frame, and further to be interchanged with other detachable temple pieces as desired. This interchangeability permits a user to change the temple piece in the event of breakage, or for purposes of changing the style and appearance of the eyeglass frame. The eyeglass frames with detachable temple pieces include a front eyewear frame having a pair of opposed side ends and a pair of temple pieces respectively, releasably and pivotally secured to the side ends of the front eyewear frame. A bridge cover is preferably provided for releasably covering a bridge of the front eyewear frame.

Abstract: Unitary structures having conductive portions electrically separated by non-conductive portions are described. In some embodiments, the non-conductive portions are made of metal oxide. In some embodiments, the method involves an oxidizing process adapted to convert an entire thickness at a selected portion of a metal substrate to a metal oxide, thereby creating metal portions that are electrically isolated from one another. In some embodiments, the thickness of the metal substrate is reduced at certain regions prior to oxidizing in order to provide a sufficiently thin metal for complete oxidization through the entire thickness. In some embodiments, the oxidizing process involves a plasma electrolytic oxidation process. In some embodiments, the plasma is concentrated at certain regions of the substrate for preferential oxidation. Applications for the substrate include enclosures and electrical components for electronic devices that use radio frequency communication.

Abstract: Unitary structures having conductive portions electrically separated by non-conductive portions are described. In some embodiments, the non-conductive portions are made of metal oxide. In some embodiments, the method involves an oxidizing process adapted to convert an entire thickness at a selected portion of a metal substrate to a metal oxide, thereby creating metal portions that are electrically isolated from one another. In some embodiments, the thickness of the metal substrate is reduced at certain regions prior to oxidizing in order to provide a sufficiently thin metal for complete oxidization through the entire thickness. In some embodiments, the oxidizing process involves a plasma electrolytic oxidation process. In some embodiments, the plasma is concentrated at certain regions of the substrate for preferential oxidation. Applications for the substrate include enclosures and electrical components for electronic devices that use radio frequency communication.

Abstract: A fastening assembly having a tubular first coupling member; a second coupling member insertable coaxially inside the first coupling member in a first direction; and releasable fastening means for locking the first and second coupling member to each other in a predetermined axial lock position. The fastening means include: first and second engaging means formed on the first and second coupling member, connectable to each other to define a foolproof angular insertion/release position, and releasable by positioning the second coupling member in a predetermined axial position inside the first coupling member; and third and fourth engaging means formed on the first and second coupling member and connectable to each other in a further angular position of the second coupling member, different from the angular insertion/release position, by moving the second coupling member axially, from the predetermined axial position, in a second direction opposite the first direction.

Abstract: A non-rotating universal joint for a helicopter drive unit has a spider defined by a ring, which has four connecting portions spaced 90° apart and engaging respective forks defining the ends of respective arms of two connecting members which, in use, are fixed with respect to a casing of an engine and a casing of a reduction gear; each fork and the corresponding connecting portion have respective through holes coaxial with one another and engaged by a screw; and dampers are interposed between the connecting portions of the ring and the shanks of the screws, and between the connecting portions of the ring and the forks.

Abstract: A fastening assembly having a longitudinal axis; a tubular first coupling member; a second coupling member insertable coaxially inside the first coupling member in a first direction; and releasable fastening means for locking the first and second coupling member to each other in a predetermined axial lock position. The fastening means include first and second engaging means formed on the first and second coupling member, connectable to each other to define a foolproof angular insertion/release position, and releasable by positioning the second coupling member in a predetermined axial position inside the first coupling member; and third and fourth engaging means formed on the first and second coupling member and connectable to each other in a further angular position of the second coupling member, different from the angular insertion/release position, by moving the second coupling member axially, from the predetermined axial position, in a second direction opposite the first direction.