Patents by Inventor Francesco Micheletto

Francesco Micheletto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Simulation of endogenous and exogenous glucose/insulin/glucagon interplay in type 1 diabetic patients
    Patent number: 10169544
    Abstract: A simulator for in-silico testing of Type 1 diabetes patients uses a model that puts in relation plasma concentrations, i.e., glucose G and insulin /, with glucose fluxes, i.e. endogenous glucose production (EGP), glucose rate of appearance (Ra), glucose utilization by the tissues (U), renal extraction (E), and insulin fluxes, i.e., rate of insulin appearance from the subcutaneous tissues (SC) and insulin degradation (D). A module is also included to describe counter-regulation, i.e. glucagon kinetics, secretion and action. A glucagon subcutaneous absorption model enables simulation of dual hormone control.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: January 1, 2019
    Assignee: University of Virginia Patent Foundation
    Inventors: Marc D. Breton, Boris P. Kovatchev, Chiara Dalla Man, Claudio Cobelli, Francesco Micheletto
  • Simulation of Endogenous and Exogenous Glucose/Insulin/Glucagon Interplay in Type 1 Diabetic Patients
    Publication number: 20160171183
    Abstract: A simulator for in-silico testing of Type 1 diabetes patients uses a model that puts in relation plasma concentrations, i.e., glucose G and insulin /, with glucose fluxes, i.e. endogenous glucose production (EGP), glucose rate of appearance (Ra), glucose utilization by the tissues (U), renal extraction (E), and insulin fluxes, i.e., rate of insulin appearance from the subcutaneous tissues (SC) and insulin degradation (D). A module is also included to describe counter-regulation, i.e. glucagon kinetics, secretion and action. A glucagon subcutaneous absorption model enables simulation of dual hormone control.
    Type: Application
    Filed: July 3, 2014
    Publication date: June 16, 2016
    Inventors: Marc D. Breton, Boris P. Kovatchev, Chiara Dalla Man, Claudio Cobelli, Francesco Micheletto