Abstract: Systems and methods for monitoring blood flow metrics using a patch of a flexible substrate configured to attach to an area of skin over a blood vessel. The patch includes a plurality of light sources arranged on the substrate to form a matrix and a row of photodetectors disposed on the substrate substantially in parallel with the rows of LEDs. The patch includes an optical signal interface configured to drive each light source and to input an intensity signal at one of the photodetectors. The intensity signals are used to determine AC and DC components corresponding to each optical path. AC to DC component ratios are calculated for each optical path and used to determine ratio-of-ratio values. At least a subset of the ratio-of-ratio values are used to determine a biological metric or a cross-sectional area of the blood vessel.

Abstract: Substituted quinazoline compounds, conjugates, and pharmaceutical compositions for use in the treatment of cancer are disclosed herein. The disclosed compounds are useful, among other things, in the inhibition of CDK. In certain aspects, the disclosure generally relates to substituted quinolinone amide compounds or salts of Formula (I), (IA), (IAA), (IAAA), (IB), (IBB), (IC), (ICC), (II), or (IIA) and pharmaceutical compositions thereof.

Abstract: A bearing and/or seal assembly where pressurized gas (e.g., air) may be arranged to produce a contact-free bearing and/or seal is provided. The assembly includes a permeable body (12) including structural features (13) selectively engineered to convey a pressurized gas (Ps) from an inlet side (20) side of the permeable body to an outlet side (22) of the permeable body to form an annular film of the pressurized gas relative to the rotatable shaft. Disclosed embodiments may be produced by way of three-dimensional (3D) Printing/Additive Manufacturing (AM) technologies with practically no manufacturing variability; and may also cost-effectively and reliably benefit from the relatively complex geometries and the features and/or conduits that may be involved to, for example, form the desired distribution pattern or impart a desired directionality to the pressurized gas conveyed through the permeable body of the bearing and/or seal assembly.

Abstract: Substituted aza-quinazoline compounds, conjugates, and pharmaceutical compositions for use in the treatment of cancer are disclosed herein. The disclosed compounds are useful, among other things, in the inhibition of CDK. In certain aspects, the disclosure generally relates to substituted quinolinone amide compounds or salts of Formula (I), (IA), (IAA), (IAAA), (IB), (IBB), (IC), (ICC), (ID), (IDD), (IE), and (IEE) and pharmaceutical compositions thereof.

Abstract: A method of treating a contaminated oil comprising preparing a brine solution, adding ozone to the brine solution to produce ozonated brine solution, adding a volume of ozonated brine solution to a volume of the contaminated oil, mixing the volumes of contaminated oil and ozonated brine solution with coagulant and surfactant at a shear rate sufficiently high so as to cause formation of an emulsion of the contaminated oil and the brine solution, stopping the mixing, thereby causing the emulsion to separate into an aqueous brine liquid phase and an oil liquid phase, separating the brine liquid phase from the oil liquid phase, and separating at least one contaminant from the oil liquid phase to produce a volume of purified oil.

Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.

Abstract: A method of treating a contaminated oil comprising preparing a brine solution, adding ozone to the brine solution to produce ozonated brine solution, adding a volume of ozonated brine solution to a volume of the contaminated oil, mixing the volumes of contaminated oil and ozonated brine solution with coagulant and surfactant at a shear rate sufficiently high so as to cause formation of an emulsion of the contaminated oil and the brine solution, stopping the mixing, thereby causing the emulsion to separate into an aqueous brine liquid phase and an oil liquid phase, separating the brine liquid phase from the oil liquid phase, and separating at least one contaminant from the oil liquid phase to produce a volume of purified oil.

Abstract: Systems and methods for determining molecular structures based on atomic-orbital-based features are described. Atomic-orbital-based features can be utilized in combination with machine-learning methods to predict accurate properties, such as quantum mechanical energy, of molecular systems.

Abstract: A bearing and/or seal assembly where pressurized gas (e.g., air) may be arranged to produce a contact-free bearing and/or seal is provided. The assembly includes a permeable body (12) including structural features (13) selectively engineered to convey a pressurized gas (Ps) from an inlet side (20) side of the permeable body to an outlet side (22) of the permeable body to form an annular film of the pressurized gas relative to the rotatable shaft. Disclosed embodiments may be produced by way of three-dimensional (3D) Printing/Additive Manufacturing (AM) technologies with practically no manufacturing variability; and may also cost-effectively and reliably benefit from the relatively complex geometries and the features and/or conduits that may be involved to, for example, form the desired distribution pattern or impart a desired directionality to the pressurized gas conveyed through the permeable body of the bearing and/or seal assembly.

Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.

Abstract: Apparatus and methods are provided for providing persistent aerial vehicle surveillance capabilities, including launch and recovery platforms, secured communication, sensor systems, targeting systems, locating systems, and precision landing and stabilization systems for such uses as assisting with base defenses, monitoring parking lots or facilities, providing security monitoring, assisting farmers, performing recon of enemy beaches or use by mortar teams in hostile fields of operations. One embodiment can include an aerial surveillance system using an aerial short wave infrared surveillance system platform for use when quick response in reaction to real-time conditions is preferred while relaying the geo-location and other monitoring assistance via a wireless, fiber optic type link, or an ADHOC GPS system.

Abstract: A method of treating a contaminated oil comprising preparing a brine solution, adding ozone to the brine solution to produce ozonated brine solution, adding a volume of ozonated brine solution to a volume of the contaminated oil, mixing the volumes of contaminated oil and ozonated brine solution with coagulant and surfactant at a shear rate sufficiently high so as to cause formation of an emulsion of the contaminated oil and the brine solution, stopping the mixing, thereby causing the emulsion to separate into an aqueous brine liquid phase and an oil liquid phase, separating the brine liquid phase from the oil liquid phase, and separating at least one contaminant from the oil liquid phase to produce a volume of purified oil.

Abstract: A method of treating an oil well or a gas well to restore production capacity. In certain embodiments, the method comprises mixing a coagulant, a surfactant, and water or production brine to produce a well treatment mixture; injecting the treatment mixture into the oil well; operating the oil well to distribute the treatment mixture throughout the oil well; and withdrawing a the treatment mixture, oil, production brine, and oil waste constituents from the oil well. As a result of the treatment compositions and methods, the oil waste constituents may include dissolved and or delaminated paraffin removed from surfaces of the oil well. In certain embodiments, following treatment, the oil well is substantially free of paraffin deposits.

Abstract: The present invention relates to methods of using optimized aptamers. In certain embodiments, the present invention provides a method for treating a subject having or being disposed to having a histone-induced injury or disease comprising administering to the subject a pharmaceutical composition comprising a pharmaceutically acceptable carrier and (i) a nucleic acid molecule not more than 90 nucleotides in length comprising an aptamer KU1, KU2, KU3, KU4, KU5, KU6, KU&, KU8, or KU9, wherein the aptamer specifically targets extracellular histones, wherein the nucleotides are RNA; or (ii) a conjugate comprising a nucleic acid molecule not more than 90 nucleotides in length comprising an aptamer KU1, KU2, KU3, KU4, KU5, KU6, KU&, KU8, or KU9, wherein the aptamer specifically targets extracellular histones, wherein the nucleotides are RNA, wherein the nucleic acid molecule is linked to a therapeutic molecule.

Abstract: A golf ball retrieval device is disclosed that includes a plurality of claws are disposed adjacent to one another and aligned in a first direction, each of the plurality of claws including a coupling portion to which at least one pivot member is fixed; a plurality of elongated rigid link members extend transversely between two or more of the plurality of claws and are arranged to pivot on two or more of the pivot members, in which the plurality of claws are movable relative to one another between a collapsed configuration and an expanded configuration; and a locking mechanism configured to secure the plurality of claws in the collapsed configuration when the locking mechanism in a first position, and to secure the plurality of claws in the expanded configuration when the locking mechanism is in a second position.

Abstract: A golf ball retrieval device is disclosed that includes a plurality of claws are disposed adjacent to one another and aligned in a first direction, each of the plurality of claws including a coupling portion to which at least one pivot member is fixed; a plurality of elongated rigid link members extend transversely between two or more of the plurality of claws and are arranged to pivot on two or more of the pivot members, in which the plurality of claws are movable relative to one another between a collapsed configuration and an expanded configuration; and a locking mechanism configured to secure the plurality of claws in the collapsed configuration when the locking mechanism in a first position, and to secure the plurality of claws in the expanded configuration when the locking mechanism is in a second position.

Abstract: Apparatus and methods are provided for providing persistent aerial vehicle surveillance capabilities, including launch and recovery platforms, secured communication, sensor systems, targeting systems, locating systems, and precision landing and stabilization systems for such uses as assisting with base defenses, monitoring parking lots or facilities, providing security monitoring, assisting farmers, performing recon of enemy beaches or use by mortar teams in hostile fields of operations. One embodiment can include an aerial surveillance system using an aerial short wave infrared surveillance system platform for use when quick response in reaction to real-time conditions is preferred while relaying the geo-location and other monitoring assistance via a wireless, fiber optic type link, or an ADHOC GPS system.

Abstract: A seat cooling system for vehicles. The seat cooling system includes a housing formed of an insulating material. The housing includes a vent and an outlet. A nozzle extends from the outlet of the housing. A fan is positioned to move air through the nozzle. The present invention may further include a seat having an outer casing and a padding disposed within the outer casing. The nozzle is connected to an inlet of the outer casing. Air is drawn into the housing through the vent, through the nozzle and into the seat.

Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.

Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.