Patents by Inventor Francis A. Stewart
Francis A. Stewart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240108840Abstract: A patient interface system for delivery of respiratory therapy to a patient comprises: a nasal portion including a nasal chamber and a nasal sealing portion adapted to form a seal with the patients including an opening; an inlet conduit connected to the nasal portion to deliver the pressurized, breathable gas to the nasal chamber; and a nasal chamber coupling component adapted to form part of a releasable fluid coupling to enable the nasal portion to be fluidly coupled to a mouth portion to communicate a portion of the pressurized, breathable gas through the nasal chamber opening to the mouth portion.Type: ApplicationFiled: September 10, 2020Publication date: April 4, 2024Inventors: Adam Francis BARLOW, Luke Andrew STANISLAS, Iain McNicol FINLAY, Christopher Daniel PARKER, Hongjiang YU, Luke Emmanuel KLINKENBERG, Hugh Francis Stewart THOMAS, Michiel KOOIJ, Paul Derrick WATSON, Rahul KHERA, Nigel Paul GREIG, Shannon DAY, Vinay MANJUNATH
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Patent number: 11866724Abstract: The invention relates to adenoviral vectors, cells for use in generating adenoviral vectors, methods for generating adenoviral vectors, and therapeutic uses of adenoviral vectors in gene therapy, tumour therapy and as vaccines.Type: GrantFiled: April 6, 2017Date of Patent: January 9, 2024Assignee: Gene Bridges GMBHInventors: Adrian Francis Stewart, Jun Fu, Anja Ehrhardt, Eric Ehrke-Schulz, Wenli Zhang
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Publication number: 20230337937Abstract: An eye mask system for providing respiratory pressure therapy (RPT) for treatment of sleep disordered breathing, comprising: an eye mask configured to cover the user’s eyes in use; one or more transducers configured to influence the user’s sleep and/ or detect characteristics of the user or the user’s sleep. The eye mask system may comprise: a connection port to receive a pressurised flow of air or a flow generator; the eye mask system may comprise a plenum chamber, a seal-forming structure to form a seal with a region of the user’s face and a vent to allow flow of gases exhaled by the user to ambient. The eye mask system may operate in a non-treatment mode in which RPT is not provided to the user, and a treatment mode in which RPT is provided to the user.Type: ApplicationFiled: June 30, 2021Publication date: October 26, 2023Inventors: Adam Francis BARLOW, Justin John FORMICA, Sung Hoon MUN, Hugh Francis Stewart THOMAS, Liam HOLLEY
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Publication number: 20230241342Abstract: Aspects of the present technology comprise a positioning and stabilising structure to hold a seal-forming structure in a therapeutically effective position on a head of a patient. The seal-forming structure may be constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways for sealed delivery of a flow of air at a therapeutic pressure of at least 4 cmH2O with respect to ambient air pressure throughout the patient's respiratory cycle in use. The positioning and stabilising structure may comprise a front hoop arranged to contact, in use, at least a region of the patient's head superior to an otobasion superior of the patient's head and a rear strap.Type: ApplicationFiled: February 8, 2023Publication date: August 3, 2023Inventors: Stewart Joseph WAGNER, Aaron Samuel DAVIDSON, Gerard Michael RUMMERY, Adam Francis BARLOW, Hugh Francis Stewart THOMAS, Justin John FORMICA, Mira ASWANI
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Publication number: 20230233885Abstract: A mask for interfacing with a user's face to reduce audible noise in a user's surroundings resulting from a user's voice. In some forms disclosed is a mask including a sound attenuating structure. In some forms the mask is also transparent or partially transparent to allow a view of the user's face.Type: ApplicationFiled: January 20, 2023Publication date: July 27, 2023Inventors: Lachlan Richard GOLDSPINK, Matthew EVES, Hugh Francis Stewart THOMAS, Lorenz EBERL, Gaetano CALDAROLA
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Patent number: 11666724Abstract: Aspects of the present technology comprise a positioning and stabilising structure to hold a seal-forming structure in a therapeutically effective position on a head of a patient. The seal-forming structure may be constructed and arranged to form a seal with a region of the patients face surrounding an entrance to the patients airways for sealed delivery of a flow of air at a therapeutic pressure of at least 4 cmH2O with respect to ambient air pressure throughout the patients respiratory cycle in use. The positioning and stabilising structure may comprise a front hoop arranged to contact, in use, at least a region of the patients head superior to an otobasion superior of the patients head and a rear strap.Type: GrantFiled: November 27, 2020Date of Patent: June 6, 2023Assignee: ResMed Pty LtdInventors: Stewart Joseph Wagner, Aaron Samuel Davidson, Gerard Michael Rummery, Adam Francis Barlow, Hugh Francis Stewart Thomas, Justin John Formica, Mira Aswani
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Publication number: 20220409841Abstract: Aspects of the present technology comprise a positioning and stabilising structure to hold a seal-forming structure in a therapeutically effective position on a head of a patient. The seal-forming structure may be constructed and arranged to form a seal with a region of the patients face surrounding an entrance to the patients airways for sealed delivery of a flow of air at a therapeutic pressure of at least 4 cmH2O with respect to ambient air pressure throughout the patients respiratory cycle in use. The positioning and stabilising structure may comprise a front hoop arranged to contact, in use, at least a region of the patients head superior to an otobasion superior of the patients head and a rear strap.Type: ApplicationFiled: November 27, 2020Publication date: December 29, 2022Inventors: Stewart Joseph WAGNER, Aaron Samuel DAVIDSON, Gerard Michael RUMMERY, Adam Francis BARLOW, Hugh Francis Stewart THOMAS, Justin John FORMICA, Mira ASWANI
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Publication number: 20200283759Abstract: A method for performing homologous recombination between at least a first nucleic acid molecule and a second nucleic acid molecule which share at least one region of sequence homology. A method for improving the efficiency of homologous recombination.Type: ApplicationFiled: September 6, 2019Publication date: September 10, 2020Inventors: Youming Zhang, Jun Fu, Adrian Francis Stewart
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Publication number: 20200010867Abstract: A method of homologous recombination, including in vitro joining two or more target nucleic acid molecules with a first exonuclease, and recombining the two or more target nucleic acid molecules in the presence of a second exonuclease and an annealing protein. The recombined target nucleic acid molecules share at least one homologous sequence.Type: ApplicationFiled: September 22, 2019Publication date: January 9, 2020Inventors: Youming ZHANG, Hailong WANG, Jun FU, Adrian Francis STEWART
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Publication number: 20190382793Abstract: The invention relates to adenoviral vectors, cells for use in generating adenoviral vectors, methods for generating adenoviral vectors, and therapeutic uses of adenoviral vectors in gene therapy, tumour therapy and as vaccines.Type: ApplicationFiled: April 6, 2017Publication date: December 19, 2019Applicant: Gene Bridges GMBHInventors: Adrian Francis Stewart, Jun Fu, Anja Ehrhardt, Eric Ehrke-Schulz, Wenli Zhang
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Patent number: 10443051Abstract: A method for performing homologous recombination between at least a first nucleic acid molecule and a second nucleic acid molecule which share at least one region of sequence homology. A method for improving the efficiency of homologous recombination.Type: GrantFiled: June 10, 2011Date of Patent: October 15, 2019Assignee: GENE BRIDGES GMBHInventors: Youming Zhang, Jun Fu, Adrian Francis Stewart
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Publication number: 20170233750Abstract: This invention is related to bacterial engineering and the heterologous expression of useful compounds. In particular, the invention relates to a heterologous host that has been engineered for expression of a gene which is capable of polyketide or non-ribosomal peptide synthesis. Methods of treating cancer are also disclosed.Type: ApplicationFiled: December 27, 2016Publication date: August 17, 2017Inventors: Youming Zhang, Jun Fu, Xiaoying Bian, Adrian Francis Stewart, Rolf Muller
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Patent number: 9580717Abstract: This invention is related to bacterial engineering and the heterologous expression of useful compounds. In particular, the invention relates to a heterologous host that has been engineered for expression of a gene which is capable of polyketide or non-ribosomal peptide synthesis. Methods of treating cancer are also disclosed.Type: GrantFiled: December 17, 2010Date of Patent: February 28, 2017Assignee: Gene Bridges GmbHInventors: Youming Zhang, Jun Fu, Xiaoying Bian, Adrian Francis Stewart, Rolf Müller
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Publication number: 20150267210Abstract: The present invention provides a method of preparing electrocompetent cells from Gram-negative bacteria characterized in that the bacteria are prepared under room temperature. Also provided are electrocompetent Gram-negative bacteria and kits which comprise the electrocompetent bacteria.Type: ApplicationFiled: October 15, 2013Publication date: September 24, 2015Inventors: Rolf Mueller, Qiang Tu, Youming Zhang, Francis Stewart, Jun Fu
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Patent number: 8871516Abstract: The present invention is directed to a method for preparing an expression vector encoding a tailored recombinase, wherein said tailored recombinase recombines asymmetric target sites within the LTR of proviral DNA of a retrovirus inserted into the genome of a host cell and is useful as means for excising the provirus from the genome of the host cell. The present invention further relates to an in vitro-method of optimising the treatment of a retroviral infection of a subject and to the use of tailored recombinases for the preparation of pharmaceutical compositions for reducing the viral load in a subjected infected by a retrovirus.Type: GrantFiled: January 3, 2008Date of Patent: October 28, 2014Assignees: Technische Universität Dresden, Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V., Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität HamburgInventors: Joachim Hauber, Frank Buchholz, Ilona Hauber, Francis A Stewart, Indrani Sarkar
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Patent number: 8728820Abstract: The invention provides a method for inserting a single stranded replacement nucleic acid into a target nucleic acid, the method comprising the steps of: a) generating a single stranded replacement nucleic acid from a double stranded nucleic acid, wherein the double stranded nucleic acid is adapted at one or both of its 5? ends such that preferential degradation of one strand and/or strand separation generates the single stranded replacement nucleic acid, wherein the single stranded replacement nucleic acid comprises a 5? region that is identical to sequence on the target nucleic acid, a 3? region that is identical to sequence on the target nucleic acid and optionally a replacement region between the 5? and 3? regions that is not identical to sequence on the target nucleic acid, b) exposing the target nucleic acid to the single stranded replacement nucleic acid under conditions suitable for recombination to occur between the single stranded replacement nucleic acid and the target nucleic acid, and c) selectingType: GrantFiled: February 20, 2009Date of Patent: May 20, 2014Assignee: Gene Bridges GmbHInventors: Marcello Maresca, Axel Steffen Erler, Jun Fu, Philipp Martin Seibert, Adrian Francis Stewart, Youming Zhang
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Publication number: 20130210681Abstract: A method for performing homologous recombination between at least a first nucleic acid molecule and a second nucleic acid molecule which share at least one region of sequence homology. A method for improving the efficiency of homologous recombination.Type: ApplicationFiled: June 10, 2011Publication date: August 15, 2013Inventors: Youming Zhang, Jun Fu, Adrian Francis Stewart
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Publication number: 20130089522Abstract: This invention is related to bacterial engineering and the heterologous expression of useful compounds. In particular, the invention relates to a heterologous host that has been engineered for expression of a gene which is capable of polyketide or non-ribosomal peptide synthesis. Methods of treating cancer are also disclosed.Type: ApplicationFiled: December 17, 2010Publication date: April 11, 2013Applicant: GENE BRIDGES GMBHInventors: Youming Zhang, Jun Fu, Xiaoying Bian, Francis Stewart, Rolf Muller
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Publication number: 20120208277Abstract: The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecule, and the second DNA molecule contains two regions with sequence homology to the first DNA molecule. Competent cells and vectors are also described.Type: ApplicationFiled: January 3, 2012Publication date: August 16, 2012Applicant: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventors: Francis STEWART, Youming ZHANG, Frank BUCHHOLZ
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Publication number: 20110165630Abstract: The invention provides a method for inserting a single stranded replacement nucleic acid into a target nucleic acid, said method comprising the steps of: a) generating a single stranded replacement nucleic acid from a double stranded nucleic acid, wherein the double stranded nucleic acid is adapted at one or both of its 5? ends such that preferential degradation of one strand and/or strand separation generates the single stranded replacement nucleic acid, wherein the single stranded replacement nucleic acid comprises a 5? region that is identical to sequence on the target nucleic acid, a 3? region that is identical to sequence on the target nucleic acid and optionally a replacement region between the 5? and 3? regions that is not identical to sequence on the target N nucleic acid, b) exposing the target nucleic acid to the single stranded replacement nucleic acid under conditions suitable for recombination to occur between the single stranded replacement nucleic acid and the target nucleic acid, and c) selectType: ApplicationFiled: February 20, 2009Publication date: July 7, 2011Applicant: Gene Bridges GmbHInventors: Marcello Maresca, Axel Steffen Erler, Jun Fu, Philipp Martin Seibert, Adrian Francis Stewart, Youming Ahang