Patents by Inventor Francis Ali-Osman

Francis Ali-Osman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High throughput detection of glutathione s-transferase polymorphic alleles
    Publication number: 20060194200
    Abstract: A high-throughput assay for characterizing a subject's genetic makeup is disclosed. Specifically, a high-throughput assay utilizing PCR is disclosed that permits the rapid and accurate characterization of a subject's inherited alleles of the polymorphic glutathione S-transferase (GST) genes GSTM1, GSTM3, GSTP1, and GSTT1. This method allows detection of the specific alleles inherited, including the gene dosage of GSTM1 and GSTT1 while not requiring restriction endonuclease digestion of the PCR products in order to detect length differences. Further, the method allows all analyses to be performed simultaneously in the same gel lane, thus further adding efficiency and cost-effectiveness.
    Type: Application
    Filed: October 15, 2003
    Publication date: August 31, 2006
    Inventors: Charles Keller, Linda Ballard, Richard Lemmons, Francis Ali-Osman
  • High-throughput glutathione S-transferase polymorphic allele assay design
    Patent number: 7083923
    Abstract: A high-throughput assay for characterizing a subject's genetic makeup is disclosed. Specifically a high-throughput assay utilizing PCR is disclosed that permits the rapid and accurate characterization of a subject's inherited alleles of the polymorphic glutathione S-transferase (GST) genes GSTM1, GSTM3, GSTP1, and GSTT1. This method allows detection of the specific alleles inherited, including the gene dosage of GSTM1 and GSTT1 while not requiring restriction endonuclease digestion of the PCR products in order to detect length differences. Further, the method allows all analyses to be performed simultaneously in the same gel lane, thus further adding efficiency and cost-effectiveness.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: August 1, 2006
    Assignee: University of Utah Research Foundation
    Inventors: Charles Keller, Linda Ballard, Richard Lemmons, Francis Ali-Osman
  • Method of identifying inhibitors of glutathione S-transferase (GST) gene expression
    Patent number: 5968737
    Abstract: Complementary DNA and genomic clones for three variants of GST-.pi. are disclosed. It is demonstrated that certain of these variants are overexpressed in gliomas, thereby indicating an involvement with that form of cancer. This permits the detection and treatment of certain classes of tumors using new compositions such as GST-.pi. genes, oligonucleotides, peptides and antibodies.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: October 19, 1999
    Assignees: The University of Mississippi, The Board of Regents, The University of Texas System
    Inventors: Francis Ali-Osman, Gabriel Lopez-Berestein, John K. Buolamwini, Gamil Antoun, Hui-Wen Lo, Charles Keller, Olanike Akande