Patents by Inventor Francis ALONZO

Francis ALONZO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cellular factors involved in the cytotoxicity of leukocidins: novel therapeutic targets
    Patent number: 11932683
    Abstract: The present invention relates to methods for treating and preventing Staphylococcus aureus infection and/or a condition resulting from a S. aureus infection in a subject that involves administering compositions that inhibit S. aureus interaction with CXCR1/CXCR2 and DARC cellular receptors. The present invention further relates to novel compositions for carrying out these and other methods.
    Type: Grant
    Filed: September 14, 2022
    Date of Patent: March 19, 2024
    Assignee: NEW YORK UNIVERSITY
    Inventors: Victor J. Torres, Tamara Reyes-Robles, Francis Alonzo
  • Cold-formed glass article with thermally matched system and process for forming the same
    Patent number: 11858351
    Abstract: A glass article is provided with a cover glass sheet having first and second major surfaces. The second major surface has a first region with a first curve of a first radius of curvature, and a second region that is different than the first region. A frame's support surface has a third region of a first frame material and a fourth region of a different, second frame material. The second major surface faces the support, and the third region includes a second curve that complements the first curve while the fourth region complements the second region. A first adhesive is between the third region and the first region. A second adhesive is disposed between the fourth region and the second region. The first adhesive has a first Young's modulus, and the second adhesive comprising a second Young's modulus that is different than the first Young's modulus.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: January 2, 2024
    Assignee: Corning Incorporated
    Inventors: Carlos Francis Alonzo, Atul Kumar, Jinfa Mou, Christopher Mark Schweiger
  • CELLULAR FACTORS INVOLVED IN THE CYTOTOXICITY OF STAPHYLOCOCCUS AUREUS LEUKOCIDINS: NOVEL THERAPEUTIC TARGETS
    Publication number: 20230151081
    Abstract: The present invention relates to methods for treating and preventing Staphylococcus aureus infection and/or a condition resulting from a S. aureus infection in a subject that involves administering compositions that inhibit S. aureus interaction with CXCR1/CXCR2 and DARC cellular receptors. The present invention further relates to novel compositions for carrying out these and other methods.
    Type: Application
    Filed: September 14, 2022
    Publication date: May 18, 2023
    Inventors: Victor J. TORRES, Tamara REYES-ROBLES, Francis ALONZO
  • Cellular factors involved in the cytotoxicity of leukocidins: novel therapeutic targets
    Patent number: 11453715
    Abstract: The present invention relates to methods for treating and preventing Staphylococcus aureus infection and/or a condition resulting from a S. aureus infection in a subject that involves administering compositions that inhibit S. aureus interaction with CXCR1/CXCR2 and DARC cellular receptors. The present invention further relates to novel compositions for carrying out these and other methods.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: September 27, 2022
    Assignee: NEW YORK UNIVERSITY
    Inventors: Victor J. Torres, Tamara Reyes-Robles, Francis Alonzo, III
  • COLD-FORMED GLASS ARTICLE WITH THERMALLY MATCHED SYSTEM AND PROCESS FOR FORMING THE SAME
    Publication number: 20220024179
    Abstract: A glass article is provided with a cover glass sheet having first and second major surfaces. The second major surface has a first region with a first curve of a first radius of curvature, and a second region that is different than the first region. A frame's support surface has a third region of a first frame material and a fourth region of a different, second frame material. The second major surface faces the support, and the third region includes a second curve that complements the first curve while the fourth region complements the second region. A first adhesive is between the third region and the first region. A second adhesive is disposed between the fourth region and the second region. The first adhesive has a first Youngs modulus, and the second adhesive comprising a second Youngs modulus that is different than the first Youngs modulus.
    Type: Application
    Filed: November 19, 2019
    Publication date: January 27, 2022
    Inventors: Carlos Francis Alonzo, Atul Kumar, Jinfa Mou, Christopher Mark Schweiger
  • METHODS OF TREATING AND PREVENTING STAPHYLOCOCCUS AUREUS INFECTIONS AND ASSOCIATED CONDITIONS
    Publication number: 20210340228
    Abstract: The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the present invention comprise leukocidin E and/or D proteins or polypeptides and anti-leukocidin E and/or D antibodies. The invention further relates to methods of identifying inhibitors of LukE/D cytotoxicity and inhibitors of LukE/D-leukocyte binding.
    Type: Application
    Filed: July 6, 2021
    Publication date: November 4, 2021
    Inventors: Victor J. TORRES, Francis ALONZO, III
  • Methods of treating and preventing infections and associated conditions
    Patent number: 11078258
    Abstract: The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the present invention comprise leukocidin E and/or D proteins or polypeptides and anti-leukocidin E and/or D antibodies. The invention further relates to methods of identifying inhibitors of LukE/D cytotoxicity and inhibitors of LukE/D-leukocyte binding.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: August 3, 2021
    Assignee: NEW YORK UNIVERSITY
    Inventors: Victor J. Torres, Francis Alonzo, III
  • CELLULAR FACTORS INVOLVED IN THE CYTOTOXICITY OF STAPHYLOCOCCUS AUREUS LEUKOCIDINS: NOVEL THERAPEUTIC TARGETS
    Publication number: 20210009664
    Abstract: The present invention relates to methods for treating and preventing Staphylococcus aureus infection and/or a condition resulting from a S. aureus infection in a subject that involves administering compositions that inhibit S. aureus interaction with CXCR1/CXCR2 and DARC cellular receptors. The present invention further relates to novel compositions for carrying out these and other methods.
    Type: Application
    Filed: June 5, 2020
    Publication date: January 14, 2021
    Inventors: Victor J. TORRES, Tamara REYES-ROBLES, Francis ALONZO, III
  • METHODS OF TREATING AND PREVENTING STAPHYLOCOCCUS AUREUS INFECTIONS AND ASSOCIATED CONDITIONS
    Publication number: 20200392211
    Abstract: The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the present invention comprise leukocidin E and/or D proteins or polypeptides and anti-leukocidin E and/or D antibodies. The invention further relates to methods of identifying inhibitors of LukE/D cytotoxicity and inhibitors of LukE/D-leukocyte binding.
    Type: Application
    Filed: April 28, 2020
    Publication date: December 17, 2020
    Inventors: Victor J. TORRES, Francis ALONZO, III
  • Methods of treating and preventing infections and associated conditions
    Patent number: 10669329
    Abstract: The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the present invention comprise leukocidin E and/or D proteins or polypeptides and anti-leukocidin E and/or D antibodies. The invention further relates to methods of identifying inhibitors of LukE/D cytotoxicity and inhibitors of LukE/D-leukocyte binding.
    Type: Grant
    Filed: January 7, 2019
    Date of Patent: June 2, 2020
    Assignee: New York University
    Inventors: Victor J. Torres, Francis Alonzo, III
  • CELLULAR FACTORS INVOLVED IN THE CYTOTOXICITY OF STAPHYLOCOCCUS AUREUS LEUKOCIDINS: NOVEL THERAPEUTIC TARGETS
    Publication number: 20190248876
    Abstract: The present invention relates to methods for treating and preventing Staphylococcus aureus infection and/or a condition resulting from a S. aureus infection in a subject that involves administering compositions that inhibit S. aureus interaction with CXCR1/CXCR2 and DARC cellular receptors. The present invention further relates to novel compositions for carrying out these and other methods.
    Type: Application
    Filed: April 24, 2019
    Publication date: August 15, 2019
    Inventors: Victor J. TORRES, Tamara REYES-ROBLES, Francis ALONZO, III
  • Cellular factors involved in the cytotoxicity of leukocidins: novel therapeutic targets
    Patent number: 10301378
    Abstract: The present invention relates to methods for treating and preventing Staphylococcus aureus infection and/or a condition resulting from a S. aureus infection in a subject that involves administering compositions that inhibit S. aureus interaction with CXCR1/CXCR2 and DARC cellular receptors. The present invention further relates to novel compositions for carrying out these and other methods.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: May 28, 2019
    Assignee: New York University
    Inventors: Victor J. Torres, Tamara Reyes-Robles, Francis Alonzo, III
  • METHODS OF TREATING AND PREVENTING STAPHYLOCOCCUS AUREUS INFECTIONS AND ASSOCIATED CONDITIONS
    Publication number: 20190135900
    Abstract: The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the present invention comprise leukocidin E and/or D proteins or polypeptides and anti-leukocidin E and/or D antibodies. The invention further relates to methods of identifying inhibitors of LukE/D cytotoxicity and inhibitors of LukE/D-leukocyte binding.
    Type: Application
    Filed: January 7, 2019
    Publication date: May 9, 2019
    Inventors: Victor J. TORRES, Francis ALONZO, III
  • Methods of treating and preventing infections and associated conditions
    Patent number: 10202440
    Abstract: The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the present invention comprise leukocidin E and/or D proteins or polypeptides and anti-leukocidin E and/or D antibodies. The invention further relates to methods of identifying inhibitors of LukE/D cytotoxicity and inhibitors of LukE/D-leukocyte binding.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: February 12, 2019
    Assignee: New York University
    Inventors: Victor J. Torres, Francis Alonzo, III
  • METHODS OF TREATING AND PREVENTING STAPHYLOCOCCUS AUREUS INFECTIONS AND ASSOCIATED CONDITIONS
    Publication number: 20180057571
    Abstract: The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the present invention comprise leukocidin E and/or D proteins or polypeptides and anti-leukocidin E and/or D antibodies. The invention further relates to methods of identifying inhibitors of LukE/D cytotoxicity and inhibitors of LukE/D-leukocyte binding.
    Type: Application
    Filed: September 8, 2017
    Publication date: March 1, 2018
    Inventors: Victor J. TORRES, Francis ALONZO
  • Methods of treating and preventing infections and associated conditions
    Patent number: 9783597
    Abstract: The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the present invention comprise leukocidin E and/or D proteins or polypeptides and anti-leukocidin E and/or D antibodies. The invention further relates to methods of identifying inhibitors of LukE/D cytotoxicity and inhibitors of LukE/D-leukocyte binding.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: October 10, 2017
    Assignee: New York University
    Inventors: Victor J. Torres, Francis Alonzo, III
  • LEUKOTOXIN E/D AS A NEW ANTI-INFLAMMATORY AGENT AND MICROBICIDE
    Publication number: 20170224768
    Abstract: The present invention relates to methods for preventing or treating Human Immunodeficiency Virus (HIV) infection, inflammatory conditions, and graft-versus-host-disease (GVHD) in a subject. Therapeutic compositions of the present invention comprise Leukocidin E (LukE) and/or D proteins or polypeptides. The invention further relates to methods of treating Staphylococcus aureus infection by administering a composition comprising a CCR5 antagonist or any molecule that blocks LukE/D interaction with CCR5+ cells in an amount effective to treat the S. aureus infection in the subject.
    Type: Application
    Filed: September 23, 2016
    Publication date: August 10, 2017
    Inventors: Victor J. TORRES, Derya UNUTMAZ, Francis ALONZO, III
  • METHODS OF TREATING AND PREVENTING STAPHYLOCOCCUS AUREUS INFECTIONS AND ASSOCIATED CONDITIONS
    Publication number: 20170008953
    Abstract: The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the present invention comprise leukocidin E and/or D proteins or polypeptides and anti-leukocidin E and/or D antibodies. The invention further relates to methods of identifying inhibitors of LukE/D cytotoxicity and inhibitors of LukE/D-leukocyte binding.
    Type: Application
    Filed: September 23, 2016
    Publication date: January 12, 2017
    Applicant: New York University
    Inventors: Victor J. TORRES, Francis ALONZO, III
  • Leukotoxin E/D as a new anti-inflammatory agent and microbicide
    Patent number: 9480726
    Abstract: The present invention relates to methods for preventing or treating Human Immunodeficiency Virus (HIV) infection, inflammatory conditions, and graft-versus-host-disease (GVHD) in a subject. Therapeutic compositions of the present invention comprise Leukocidin E (LukE) and/or D proteins or polypeptides. The invention further relates to methods of treating Staphylococcus aureus infection by administering a composition comprising a CCR5 antagonist or any molecule that blocks LukE/D interaction with CCR5+ cells in an amount effective to treat the S. aureus infection in the subject.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: November 1, 2016
    Assignee: New York University
    Inventors: Victor J. Torres, Derya Unutmaz, Francis Alonzo, III
  • Methods of treating and preventing infections and associated conditions
    Patent number: 9481723
    Abstract: The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the present invention comprise leukocidin E and/or D proteins or polypeptides and anti-leukocidin E and/or D antibodies. The invention further relates to methods of identifying inhibitors of LukE/D cytotoxicity and inhibitors of LukE/D-leukocyte binding.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: November 1, 2016
    Assignee: New York University
    Inventors: Victor J. Torres, Francis Alonzo, III