Patents by Inventor Francis Beaulieu

Francis Beaulieu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic heterocycles as HIV integrase inhibitors
    Patent number: 7157447
    Abstract: The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS.
    Type: Grant
    Filed: November 29, 2005
    Date of Patent: January 2, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: B. Narasimhulu Naidu, Jacques Banville, Francis Beaulieu, Timothy P. Connolly, Mark R. Krystal, John D. Matiskella, Carl Ouellet, Serge Plamondon, Roger Remillard, Margaret E. Sorenson, Yasutsugu Ueda, Michael A. Walker
  • Bicyclic heterocycles as HIV integrase inhibitors
    Publication number: 20060276466
    Abstract: The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Application
    Filed: August 16, 2006
    Publication date: December 7, 2006
    Inventors: B. Naidu, Jacques Banville, Francis Beaulieu, Timothy Connolly, Mark Krystal, John Matiskella, Carl Ouellet, Serge Plamondon, Roger Remillard, Margaret Sorenson, Yasutsugu Ueda, Michael Walker
  • Topoisomerase inhibitors
    Patent number: 7138377
    Abstract: The present invention concerns novel sugar derivatives of indolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: November 21, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Edward H. Ruediger, Neelakantan Balasubramanian, Mikael Mahler, Carol Bachand, Francis Beaulieu
  • Bicyclic heterocycles as HIV integrase inhibitors
    Publication number: 20060199956
    Abstract: The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Application
    Filed: November 29, 2005
    Publication date: September 7, 2006
    Inventors: B. Naidu, Jacques Banville, Francis Beaulieu, Timothy Connolly, Mark Krystal, John Matiskella, Carl Ouellet, Serge Plamondon, Roger Remillard, Margaret Sorenson, Yasutsugu Ueda, Michael Walker
  • Bicyclic heterocycles as HIV integrase inhibitors
    Publication number: 20050267105
    Abstract: The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Application
    Filed: May 11, 2005
    Publication date: December 1, 2005
    Inventors: B. Naidu, Jacques Banville, Francis Beaulieu, Timothy Connolly, Mark Krystal, John Matiskella, Carl Ouellet, Serge Plamondon, Roger Remillard, Margaret Sorenson, Yasutsugu Ueda, Michael Walker
  • Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same
    Patent number: 6960585
    Abstract: Compounds of formula (I), or pharmaceutically-acceptable salts thereof, are useful in treating inflammatory and immune diseases and disorders, wherein X, Y1, Y2, and R2-4 are as defined in the specification.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: November 1, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Francis Beaulieu, Carl Quellet, Makonen Belema, Yuping Qiu, Xuejie Yang, Fred C. Zusi
  • Thiophene-based tricyclic compounds and pharmaceutical compositions comprising same
    Patent number: 6933294
    Abstract: Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, are useful as anti-inflammatory agents, in which R1, R2, and R3 are hydrogen, halogen, alkyl, or perfluoroalkyl; R4 is an optionally substituted alkyl or cycloalkyl group; X is a linker; A is an aryl, heteroaryl, heterocycle, cycloalkyl, or is absent; and R7 is a substituent on A as defined in the specification.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: August 23, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Makonen Belema, Amy Bunker, Van Nguyen, Francis Beaulieu, Carl Ouellet, Anne Marinier, Stephan Roy, Xuejie Yang, Yuping Qiu, Yunhui Zhang, Alain Martel, Christopher Zusi
  • Benzimidazole C-2 heterocycles as kinase inhibitors
    Publication number: 20050054655
    Abstract: Benzimidazole derivatives having the general formula I are provided. These compounds are useful as tyrosine kinase inhibitors, especially for the treatment of cancer.
    Type: Application
    Filed: July 20, 2004
    Publication date: March 10, 2005
    Inventors: Francis Beaulieu, Anne Marinier, Carl Ouellet, Stephan Roy, Mark Wittman
  • Topoisomerase I selective cytotoxic sugar derivatives of indolopyrrolocarbazoles
    Patent number: 6855698
    Abstract: The present invention relates to fluoro sugar and other sugar derivatives of indolopyrrolocarbazoles, their salts and hydrates, which exhibit selective topoisomerase I (topo I) activity, are useful in inhibiting the proliferation of tumor cells and exhibit an antitumor effect, as well as processes for their preparation.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: February 15, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Edward H. Ruediger, Mark G. Saulnier, Francis Beaulieu, Carol Bachand, Neelakantan Balusubramanian, Byron Hepler Long, David B. Frennesson, Kurt Zimmermann, B. Narasimhulu Naidu, Karen Stoffan, Denis Robert St. Laurent
  • Novel tyrosine kinase inhibitors
    Publication number: 20040180897
    Abstract: The present invention provides compounds of formula I 1
    Type: Application
    Filed: January 5, 2004
    Publication date: September 16, 2004
    Inventors: Francis Beaulieu, Carl Ouellet, Kurt Zimmermann, Upender Velaparthi, Mark D. Wittman
  • Thiophene-based tricyclic compounds and pharmaceutical compositions comprising same
    Publication number: 20040058930
    Abstract: Compounds having the formula (I), 1
    Type: Application
    Filed: March 27, 2003
    Publication date: March 25, 2004
    Inventors: Makonen Belema, Amy Bunker, Van Nguyen, Francis Beaulieu, Carl Ouellet, Anne Marinier, Stephan Roy, Xuejie Yang, Yuping Qiu, Yunhui Zhang, Alain Martel, Christopher Zusi
  • Topoisomerase inhibitors
    Patent number: 6677450
    Abstract: The present invention relates to novel N12, N13-bridged sugar derivatives of indolylopyrrolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: January 13, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Mark G. Saulnier, Edward H. Ruediger, Neelakantan Balasubramanian, Mikael Mahler, Francis Beaulieu, Carol Bachand, David B. Frennesson
  • Tumor proliferation inhibitors
    Patent number: 6653290
    Abstract: The present invention concerns novel sugar derivatives of indolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: November 25, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Edward H. Ruediger, Neelakantan Balasubramanian, Mikael Mahler, Carol Bachand, Francis Beaulieu
  • Topoisomerase inhibitors
    Publication number: 20030203860
    Abstract: The present invention concerns novel sugar derivatives of indolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells.
    Type: Application
    Filed: May 9, 2003
    Publication date: October 30, 2003
    Applicant: Bristol-Myers Squibb Company
    Inventors: Edward H. Ruediger, Neelakantan Balasubramanian, Mikael Mahler, Carol Bachand, Francis Beaulieu
  • Topoisomerase I selective cytotoxic sugar derivatives of indolopyrrolocarbazoles
    Publication number: 20030083271
    Abstract: The present invention relates to fluoro sugar and other sugar derivatives of indolopyrrolocarbazoles, their salts and hydrates, which exhibit selective topoisomerase I (topo I) activity, are useful in inhibiting the proliferation of tumor cells and exhibit an antitumor effect, as well as processes for their preparation.
    Type: Application
    Filed: March 22, 2002
    Publication date: May 1, 2003
    Inventors: Edward H. Ruediger, Mark G. Saulnier, Francis Beaulieu, Carol Bachand, Neelakantan Balusubramanian, Byron Hepler Long, David B. Frennesson, Kurt Zimmermann, B. Narasimhulu Naidu, Karen Stoffan, Denis Robert St. Laurent
  • Topoisomerase inhibitors
    Publication number: 20020107237
    Abstract: The present invention relates to novel N12, N13-bridged sugar derivatives of indolylopyrrolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells.
    Type: Application
    Filed: September 27, 2001
    Publication date: August 8, 2002
    Inventors: Mark G. Saulnier, Edward H. Ruediger, Neelakantan Balasubramanian, Mikael Mahler, Francis Beaulieu, Carol Bachand, David B. Frennesson
  • Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same
    Publication number: 20020072523
    Abstract: Compounds of formula (I), or pharmaceutically-acceptable salts thereof, are useful in treating inflammatory and immune diseases and disorders, 1
    Type: Application
    Filed: September 27, 2001
    Publication date: June 13, 2002
    Inventors: Francis Beaulieu, Carl Ouellet, Makonen Belema, Yuping Qiu, Xuejie Yang, Fred C. Zusi
  • Tumor proliferation inhibitors
    Publication number: 20020068705
    Abstract: The present invention concerns novel sugar derivatives of indolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells.
    Type: Application
    Filed: September 25, 2001
    Publication date: June 6, 2002
    Inventors: Edward H. Ruediger, Neelakantan Balasubramanian, Mikael Mahler, Carol Bachand, Francis Beaulieu