Patents by Inventor Francis Blanche

Francis Blanche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition intended for the preservation of infectious recombinant adenoviruses
    Patent number: 7202078
    Abstract: Liquid or frozen compositions containing adenoviral-particles, comprising a buffer solution capable of maintaining the pH of the medium at slightly alkaline values, supplemented with glycerol and without addition of divalent metal cations or of alkali metal cations.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: April 10, 2007
    Assignee: Centelion
    Inventors: Francis Blanche, Shian-Jiun Shih
  • Processes for purifying and for detecting target double-stranded DNA sequences by triple helix interaction
    Publication number: 20060205000
    Abstract: The present invention relates to novel target double-stranded DNA sequences capable of interacting with a third strand and of forming a stable triple helix. The present invention also relates to a process for purifying a double-stranded DNA molecule, according to which a solution containing said DNA molecule is brought into contact with a third DNA strand capable of forming, by hybridization, a triple helix structure with a target double-stranded DNA sequence carried by said DNA molecule.
    Type: Application
    Filed: March 20, 2006
    Publication date: September 14, 2006
    Inventors: Francis Blanche, Beatrice Cameron
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Patent number: 7090999
    Abstract: The invention concerns methods for preparing pristinamycin IIA or IIB.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: August 15, 2006
    Assignee: sanofi-aventis
    Inventors: Veronique Blanc, Francis Blanche, Joel Crouzet, Nathalie Jacques, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard
  • Processes for purifying and for detecting target double-stranded DNA sequences by triple helix interaction
    Patent number: 7052838
    Abstract: The present invention relates to novel target double-stranded DNA sequences capable of interacting with a third strand and of forming a stable triple helix. The present invention also relates to a process for purifying a double-stranded DNA molecule, according to which a solution containing said DNA molecule is brought into contact with a third DNA strand capable of forming, by hybridization, a triple helix structure with a target double-stranded DNA sequence carried by said DNA molecule.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: May 30, 2006
    Assignee: Centelion
    Inventors: Francis Blanche, Béatrice Cameron
  • Purification of a triple heli formation with an immobilized oligonucleotide
    Patent number: 7038026
    Abstract: Method for double-stranded DNA purification, by which a solution containing said DNA in a mixture with other components is passed over a support on which is covalently coupled in oligonucleotide capable of hybridizing with a specific sequence present on said DNA to form a triple helix.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: May 2, 2006
    Assignee: Centelion
    Inventors: Joël Crouzet, Daniel Scherman, Pierre Wils, Françis Blanche, Béatrice Cameron
  • Purification of a triple helix formation with an immobilized oligonucleotide
    Publication number: 20060036085
    Abstract: Method for double-stranded DNA purification, by which a solution containing said DNA in a mixture with other components is passed over a support on which is covalently coupled in oligonucleotide capable of hybridizing with a specific sequence present on said DNA to form a triple helix.
    Type: Application
    Filed: October 20, 2005
    Publication date: February 16, 2006
    Applicant: Centelion
    Inventors: Joel Crouzet, Daniel Scherman, Pierre Wils, Francis Blanche, Beatrice Cameron
  • Methods of increasing the production of cobalamins using cob gene expression
    Publication number: 20060019352
    Abstract: Novel polypeptides involved in the biosynthesis of cobalamines and/or cobamides, in particular coenzyme B12, genetic material responsible for expressing these polypeptides, and a method for preparing them, are described. A method for amplifying the production of cobalamines, and particularly coenzyme B12, using recombinant DNA techniques, are also described.
    Type: Application
    Filed: December 1, 2003
    Publication date: January 26, 2006
    Inventors: Francis Blanche, Beatrice Cameron, Joel Crouzet, Laurent Debussche, Sophie Levy Schil, Denis Thibaut
  • Method for producing recombinant adenovirus
    Publication number: 20050287657
    Abstract: The invention concerns a method for producing recombinant adenovirus by which viral DNA is introduced in a packaging cell culture and the viruses produced are harvested after liberation in the supernatant. The invention also concerns the viruses produced and their use.
    Type: Application
    Filed: March 23, 2005
    Publication date: December 29, 2005
    Inventors: Francis Blanche, Jean-Marc Guillaume
  • Method for producing recombinant adenovirus
    Patent number: 6905862
    Abstract: The invention concerns a method for producing recombinant adenovirus by which viral DNA is introduced in a packaging cell culture and the viruses produced are harvested after liberation in the supernatant. The invention also concerns the viruses produced and their use.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: June 14, 2005
    Assignee: Centelion
    Inventors: Francis Blanche, Jean-Marc Guillaume
  • Smoke detector with battery pack
    Publication number: 20050099312
    Abstract: The addition of wiring from Smoke Detector and the addition of a Battery Pack connected to the Smoke Detector by the wiring is a design change over existing Smoke Detectors.
    Type: Application
    Filed: November 10, 2003
    Publication date: May 12, 2005
    Inventor: Francis Blanche
  • Streptogramins and method for preparing same by mutasynthesis
    Patent number: 6833382
    Abstract: Novel group B streptogramin-like compounds of general formula (I), and a method for preparing streptogramines by mutasynthesis using a mutated micro-organism to influence the biosynthesis of at least one of the precursors of group B streptogramins are disclosed. Novel nucleotide sequences involved in the biosynthesis of said precursors, and their uses, are also disclosed.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: December 21, 2004
    Assignee: Aventis Pharma S.A.
    Inventors: Véronique Blanc, Denis Thibaut, Nathalie Bamas-Jacques, Francis Blanche, Joël Crouzet, Jean-Claude Barriere, Laurent Debussche, Alain Famechon, Jean-Marc Paris, Gilles Dutruc-Rosset
  • DNA molecules, preparation and use in gene therapy
    Patent number: 6825012
    Abstract: The invention provides double-stranded circular DNA molecules having one or more genes of interest, but lacking an origin of replication and a selectable marker, and methods for making such molecules.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: November 30, 2004
    Assignee: Gencell S.A.
    Inventors: Francis Blanche, Béatrice Cameron
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Publication number: 20040229236
    Abstract: The invention concerns methods for preparing pristinamycin IIA or IIB.
    Type: Application
    Filed: November 20, 2003
    Publication date: November 18, 2004
    Applicant: Aventis Pharma
    Inventors: Veronique Blanc, Francis Blanche, Joerl Crouzet, Nathalie Jacoues, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard
  • Composition intended for the preservation of infectious recombinant adenoviruses
    Publication number: 20040191909
    Abstract: Liquid or frozen compositions containing adenoviral-particles, comprising a buffer solution capable of maintaining the pH of the medium at slightly alkaline values, supplemented with glycerol and without addition of divalent metal cations or of alkali metal cations.
    Type: Application
    Filed: March 31, 2004
    Publication date: September 30, 2004
    Applicant: Gencell SA
    Inventors: Francis Blanche, Shian-Jiun Shih
  • Composition intended for the preservation of infectious recombinant adenoviruses
    Patent number: 6734008
    Abstract: Liquid or frozen compositions containing adenoviral particles, comprising a buffer solution capable of maintaining the pH of the medium at slightly alkaline values, supplemented with glycerol and without addition of divalent metal cations or of alkali metal cations.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: May 11, 2004
    Assignee: Gencell S.A.
    Inventors: Francis Blanche, Shian-Jiun Shih
  • Novel topoisomerase IV, corresponding nucleotide sequences and uses thereof
    Publication number: 20040077005
    Abstract: The present invention generally relates to a novel topoisomerase IV, the nucleotide sequences encoding this enzyme, their corresponding vectors, and the use of this enzyme for screening biologically active products.
    Type: Application
    Filed: August 25, 2003
    Publication date: April 22, 2004
    Applicant: Aventis Pharma S.A.
    Inventors: Francis Blanche, Beatrice Cameron, Joel Crouzet, Alain Famechon, Lucia Ferrero
  • Abrogen polypeptides, nucleic acids encoding them and methods for using them to inhibit angiogenesis
    Publication number: 20040052810
    Abstract: The present invention relates to novel nucleic acids encoding novel amino acid fragments of polypeptides, called abrogens. The present invention also relates to novel, potent in vitro and in vivo inhibitors of endothelial cell proliferation, and compositions of them and their use. The present invention further provides methods for modulating angiogenesis and/or inhibiting unwanted angiogenesis. Polypeptides according to the present invention are useful for developing cell growth-modulating compositions and methods and for treating and/or preventing cancer, tumor growth, or other angiogenic dependent or angiogenesis associated diseases.
    Type: Application
    Filed: April 29, 2003
    Publication date: March 18, 2004
    Inventors: Mark Nesbit, Beatrice Cameron, Francis Blanche
  • Kringle polypeptides and methods for using them to inhibit angiogenesis
    Publication number: 20040052777
    Abstract: The present invention relates to kringle polypeptides and polynucleotides encoding kringle polypeptides and their use as therapeutic agents and in methods of identifying agonist compounds. In effect, the kringle polypeptides according to the present invention are particularly useful for inhibiting in vitro and in vivo proliferation, migration and/or invasion of endothelial cells, recruitment of smooth muscle cells, and/or the formation of vasculature in a tissue. The present invention also relates to the use of kringle polypeptides for treating and/or preventing angiogenesis in tumors and inhibiting the growth of tumors. The present invention further relates to a method of modulating angiogenesis in cells affected by an angiogenic-dependent process and inhibiting unwanted or unregulated angiogenesis in an angiogenesis-associated disease. The present invention also concerns a method of production and purification of kringle polypeptides in a soluble and active form.
    Type: Application
    Filed: April 29, 2003
    Publication date: March 18, 2004
    Inventors: Mark Nesbit, Beatrice Cameron, Francis Blanche
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Patent number: 6670157
    Abstract: The invention concerns methods for preparing pristinamycin IIB and methods for preparing modified pristinamycin IIB.
    Type: Grant
    Filed: August 9, 2000
    Date of Patent: December 30, 2003
    Assignee: Aventis Pharma S.A.
    Inventors: Veronique Blanc, Francis Blanche, Joel Crouzet, Nathalie Jacques, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard
  • Methods of increasing the production of cobalamins using cob gene expression
    Patent number: 6656709
    Abstract: Novel polypeptides involved in the biosynthesis of cobalamines and/or cobamides, in particular coenzyme B12, genetic material responsible for expressing these polypeptides, and a method for preparing them, are described. A method for amplifying the production of cobalamines, and particularly coenzyme B12, using recombinant DNA techniques, are also described.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: December 2, 2003
    Assignee: Rhone-Poulenc Biochimie, et al.
    Inventors: Francis Blanche, Beatrice Cameron, Joel Crouzet, Laurent Debussche, Sophie Levy Schil, Denis Thibaut