Abstract: Methods, systems, and apparatus for processing image content items. In one aspect, a method includes receiving a set of search query suggestions, each search query suggestion being based on the search query and different from the search query; receiving data identifying a respective set of resources determined to be responsive to the search query; for each search query suggestion: receiving data identifying resources determined to be responsive to the search query suggestion and determining if the respective set of resources determined to be responsive to the search query suggestion meets an overlap threshold; for only each search query suggestion for which the respective set of resources is not determined to meet the overlap threshold: selecting a subset of resources of the respective set of resources determined to be responsive to the search query suggestion as a representative resource set and generating data depicting the representative resource set.

Abstract: Methods, systems, and apparatus for processing image content items. In one aspect, a method includes receiving a set of search query suggestions, each search query suggestion being based on the search query and different from the search query; receiving data identifying a respective set of resources determined to be responsive to the search query; for each search query suggestion: receiving data identifying resources determined to be responsive to the search query suggestion and determining if the respective set of resources determined to be responsive to the search query suggestion meets an overlap threshold; for only each search query suggestion for which the respective set of resources is not determined to meet the overlap threshold: selecting a subset of resources of the respective set of resources determined to be responsive to the search query suggestion as a representative resource set and generating data depicting the representative resource set.

Abstract: Methods, systems, and apparatus for processing image content items. In one aspect, a method includes receiving a set of search query suggestions for a query, each search query suggestion being based on the search query; for each search query suggestion, receiving data identifying a respective set of resources determined to be responsive to the search query suggestion; for each respective set of resources, generating a representative resource set depicting a subset of the respective set of resources; providing to the user device, in response the search query, a search results page resource including instructions that cause the user device to render a search results page that includes: a set of search results that identify resources that are determined to be responsive to the search query; for each search query suggestion, a search query suggestion grouping including: data describing the search query suggestion, and data depicting the representative resource set.

Abstract: This invention uses one or more cancellation modules to eliminate the transmitter leakage at the output of the receive antenna and prior the receiver circuitry so that the received signals can be analyzed without degradation in quality due to simultaneous operation of the transmitter and receiver. Each cancellation circuit could be limited to only 30-50 dB of rejection due to component mismatches and other circuit non-idealities. To obtain further cancellation, more than one cancellation circuit can be applied after the first low noise amplifier. The output of the low noise amplifier can be repeatedly mixed with additional cancellation signals “n” number of times such that the “n” low noise amplifier is mixed with the “nth” cancellation signal. For each additional cancellation signal added a 20-30 dB reduction in noise may be achieved such that cascading three or four cancellation signals from cancellation modules may produce a 150 dB gain.

Abstract: Methods, systems, and apparatus for processing image content items. In one aspect, a method includes receiving a set of search query suggestions for a query, each search query suggestion being based on the search query; for each search query suggestion, receiving data identifying a respective set of resources determined to be responsive to the search query suggestion; for each respective set of resources, generating a representative resource set depicting a subset of the respective set of resources; providing to the user device, in response the search query, a search results page resource including instructions that cause the user device to render a search results page that includes: a set of search results that identify resources that are determined to be responsive to the search query; for each search query suggestion, a search query suggestion grouping including: data describing the search query suggestion, and data depicting the representative resource set.

Abstract: Methods, systems, and apparatus for processing image content items. In one aspect, a method includes receiving a set of search query suggestions for a query, each search query suggestion being based on the search query; for each search query suggestion, receiving data identifying a respective set of resources determined to be responsive to the search query suggestion; for each respective set of resources, generating a representative resource set depicting a subset of the respective set of resources; providing to the user device, in response the search query, a search results page resource including instructions that cause the user device to render a search results page that includes: a set of search results that identify resources that are determined to be responsive to the search query; for each search query suggestion, a search query suggestion grouping including: data describing the search query suggestion, and data depicting the representative resource set.

Abstract: Methods, systems, and apparatus for processing image content items. In one aspect, a method includes receiving a set of search query suggestions for a query, each search query suggestion being based on the search query; for each search query suggestion, receiving data identifying a respective set of resources determined to be responsive to the search query suggestion; for each respective set of resources, generating a representative resource set depicting a subset of the respective set of resources; providing to the user device, in response the search query, a search results page resource including instructions that cause the user device to render a search results page that includes: a set of search results that identify resources that are determined to be responsive to the search query; for each search query suggestion, a search query suggestion grouping including: data describing the search query suggestion, and data depicting the representative resource set.

Abstract: This invention uses one or more cancellation modules to eliminate the transmitter leakage at the output of the receive antenna and prior the receiver circuitry so that the received signals can be analyzed without degradation in quality due to simultaneous operation of the transmitter and receiver. Each cancellation circuit could be limited to only 30-50 dB of rejection due to component mismatches and other circuit non-idealities. To obtain further cancellation, more than one cancellation circuit can be applied after the first low noise amplifier. The output of the low noise amplifier can be repeatedly mixed with additional cancellation signals “n” number of times such that the “n” low noise amplifier is mixed with the “nth” cancellation signal. For each additional cancellation signal added a 20-30 dB reduction in noise may be achieved such that cascading three or four cancellation signals from cancellation modules may produce a 150 dB gain.

Abstract: This invention provides a dual-modality system for performing characterization and imaging of tissue, tumors, structures, lesions, and ablations under investigation. Specifically, the invention couples ultrasound technology comprising at least two focused ultrasound beams for vibrating target tissues located at the focal point of the ultrasound beams intersection with a radio frequency system for measuring the response of the target tissues. The ultrasound system vibrates the target tissues while the reflected radio frequency energy is transmitted into the target tissues. When reflected, the main carrier tone of the reflected radio frequency energy is cancelled and analysis is performed on the remaining sideband frequencies.

Abstract: This invention provides a dual-modality system for performing characterization and imaging of tissue, tumors, structures, lesions, and ablations under investigation. Specifically, the invention couples ultrasound technology comprising at least two focused ultrasound beams for vibrating target tissues located at the focal point of the ultrasound beams intersection with a radio frequency system for measuring the response of the target tissues. The ultrasound system vibrates the target tissues while the reflected radio frequency energy is transmitted into the target tissues. When reflected, the main carrier tone of the reflected radio frequency energy is cancelled and analysis is performed on the remaining sideband frequencies.

Abstract: The present invention relates to antibodies against interleukin-1 receptor (IL-1R), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. The antibodies of the present invention are particularly useful for treating a variety of inflammatory diseases including, but not limited to, rheumatoid arthritis.

Abstract: The present invention provides for modified forms of anti-CD52 antibodies with reduced numbers of potential T-cell epitopes that are expected to display decreased immunogenicity.

Abstract: Antibodies or functional antibody fragments that recognize or interfere with the production of a component of the CD3 antigen complex are de-immunized.

Abstract: The invention relates to artificial modified proteins, preferably fusion proteins, having a reduced immunogenicity compared to the parent non-modified molecule when exposed to a species in vivo. The invention relates, above all, to novel immunoglobulin fusion proteins which essentially consist of an immunoglobulin molecule or a fragment thereof covalently fused via its C-terminus to the N-terminus of a biologically active non-immunoglobulin molecule, preferably a polypeptide or protein or a biologically active fragment thereof. In a specific embodiment, the invention relates to fusion proteins consisting of an Fc portion of an antibody which is fused as mentioned to the non-immunological target molecule which elicits biological or pharmacological efficacy. The molecules of the invention have amino acid sequences which are altered in one or more amino acid residue positions but have in principal the same biological activity as compared with the non-altered molecules.

Abstract: The invention provides immunogenicity-reduced antibodies or antibody fragments that bind a human CR1 receptor. The immunogenicity-reduced anti-CR1 antibody of the invention comprises one or more non-human sequences modified to comprise one or more amino acid substitutions so that the immunogenicity-reduced antibody id non-immunogenic or less immunogenic to a human. The invention also provides bispecific molecules comprising such an immunogenicity-reduced anti-CR1 antibody and an antigen-recognition portion that binds a pathogen. The invention further provides methods and compositions for the treatment of diseases or disorders caused by a blood-borne immunogenic pathogen using the bispecific molecule the invention of the invention.

Abstract: The invention concerns human interferon alpha and in particular modified forms of interferon alpha 2 with improved properties. The improved proteins contain amino acid substitutions at specific positions that confer increased relative activity in biological assays. The invention provides also modified interferon alpha with improved biological activity concomitant with reduced immunogenic potential in the protein. The improved proteins are intended for therapeutic use in the treatment of diseases in humans.

Abstract: A target protein is rendered less immunogenic to a given species by (a) determining at least part of the amino acid sequence of the target protein; (b) identifying in the amino acid sequence one or more potential epitopes for T-cells (“T-cell epitopes”) of the given species; and (c) modifying the amino acid sequence to eliminate at least one of the T-cell epitopes identified in step (b) to reduce the immunogenicity of the protein when exposed to the immune system of the given species.

Abstract: The present invention relates generally to carrier molecules derived from one animal or avian species or strains and which are substantially non-immunogenic when exposed to an immune system from a species or strain of another animal or avian creature. More particularly, the present invention provides deimmunized immunointeractive molecules and even more particular deimmunized antibodies for use in diagnostic and therapeutic applications.

Abstract: The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular to the modification of human interferon alpha and specifically interferon alpha 2(INF?2) to result in proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when use in vivo.

Abstract: The invention relates to the identification of epitopes for T-cells in human EPO as well as T-cell epitope peptides derived from EPO by means of which it is possible to create novel modified EPO variants with reduced immunogenicity.