Abstract: The technology disclosed provides systems and methods that display database objects representing entities, placement channels and workflow status in an insurance or other risk transfer program. Specially coded distribution trees and graphs of nodes represent the overall flow and, optionally, status of placement workflows. Node and edge data generated for display depicts multiple risk placements on behalf of at least one requesting party through intermediaries to responding parties. Line width of edges represents calculated relative size of placements, and pattern, style, and color of edges can depict statuses of the risk placements. Another geo-coded map display also depicts as nodes a requesting party, intermediaries and responding parties, connected by edges that represent communication channels.

Abstract: Disclosed herein are modular enclosures for temperature-sensitive components that include a modular wall section some of which include a vertical support panel, a vertical strut channel connected to the vertical support panel, and a temperature-sensitive component connected to the vertical strut channel.

Abstract: Antibody-based methods of detecting of molecules interacting with a target molecule, such as a nuclear or cytoplasmic protein, in a fixed and, optionally, permeabilized cell or tissue sample. In one example, the target molecule is bound by a primary antibody, and a secondary, peroxidase-conjugated antibody, then binds to the primary antibody. The peroxidase may also be conjugated the primary antibody. Biotin tyramide is added to the sample, and the peroxidase generates short-lived intermediates resulting in biotinylation of molecules adjacent to the peroxidase. Biotinylated molecules can be isolated from the sample by affinity interaction with avidin- or streptavidin, resulting in a fraction containing biotinylated molecules that are located in the sample in proximity to the target molecule. The fraction can be analyzed by mass-spectroscopy, Western blotting, sequencing and other techniques.

Abstract: Certain specific embodiments disclosed herein include modular building structures that include: a first wall and a first support panel connected to a second wall and a second support panel, wherein: the first support panel is integral with the first wall or is adjacent to and connected to the first wall; the second support panel is integral with the second wall or is adjacent to and connected to the second wall; the first support panel includes two first vertical elongated slots; the second support panel includes two second vertical elongated slots; and a clip having two prongs disposed within the two first vertical elongated slots and two prongs disposed within the two second vertical elongate slots.

Abstract: One or more specific versions disclosed herein includes a method for assembling a roof including: covering a first portion of a roof ridge with a first ridge cap having a first groove disposed therein; covering a second portion of the roof ridge with a second ridge cap having a second groove disposed therein, wherein the first groove and the second groove are combined to form a third groove; and sliding a rafter cover having a finger with a beveled edge along a rafter in the direction of the ridge caps, wherein the beveled edge passes through the third groove.

Abstract: A system for collecting and communicating data associated with at least one of a plurality of machines includes a sensor. The sensor is configured to monitor an operational condition of the at least one associated machine and provide signals indicative of the operational condition. The system includes at least one local data system, including a processor, associated with the machine and configured to receive signals from the sensor, detect an event affecting the at least one machine based on the signals received from the sensor, and communicate data relevant to the detected event to a location remote from the at least one machine. A central data system including a processor and configured to receive the data relevant to the detected event and communicate with other machines of the plurality of much such that the other machines communicate data relevant to the detected event to the central data system is included.

Abstract: A system for collecting and communicating data associated with at least one of a plurality of machines includes a sensor. The sensor is configured to monitor an operational condition of the at least one associated machine and provide signals indicative of the operational condition. The system includes at least one local data system, including a processor, associated with the machine and configured to receive signals from the sensor, detect an event affecting the at least one machine based on the signals received from the sensor, and communicate data relevant to the detected event to a location remote from the at least one machine. A central data system including a processor and configured to receive the data relevant to the detected event and communicate with other machines of the plurality of much such that the other machines communicate data relevant to the detected event to the central data system is included.

Abstract: A system for collecting and communicating data associated with at least one of a plurality of machines includes a sensor. The sensor is configured to monitor an operational condition of the at least one associated machine and provide signals indicative of the operational condition. The system includes at least one local data system, including a processor, associated with the machine and configured to receive signals from the sensor, detect an event affecting the at least one machine based on the signals received from the sensor, and communicate data relevant to the detected event to a location remote from the at least one machine. A central data system including a processor and configured to receive the data relevant to the detected event and communicate with other machines of the plurality of much such that the other machines communicate data relevant to the detected event to the central data system is included.

Abstract: Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal protein. In addition to the novel Lamin A variant protein and nucleic acids encoding this variant, methods of using these molecules in detecting biological conditions associated with a LMNA mutation in a subject (e.g., HGPS, arteriosclerosis, and other age-related diseases), methods of treating such conditions, methods of selecting treatments, methods of screening for compounds that influence Lamin A activity, and methods of influencing the expression of LMNA or LMNA variants are also described.

Abstract: A method of interfacing an electronic device to a manually operable fabric controller forming part of a personal item, such as an item of clothing or bag. A set of interface devices, each comprising a housing enclosing a processing circuit with analogue ports and control ports, and supporting a first physical interface connected to analogue ports and connectable to a fabric sensor and a second physical interface connected to control ports and connectable to a specific type of electronic device. In this way, it is possible for different electronic devices to be controlled by operation of the fabric sensor supported by the personal item. A method of establishing a music-enabled item of clothing or bag. The identification of an appropriate interface device is facilitated at locations where electronic devices or accessories are made available. The fabric sensor may be removable from the personal item.

Abstract: Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal protein. In addition to the novel Lamin A variant protein and nucleic acids encoding this variant, methods of using these molecules in detecting biological conditions associated with a LMNA mutation in a subject (e.g., HGPS, arteriosclerosis, and other age-related diseases), methods of treating such conditions, methods of selecting treatments, methods of screening for compounds that influence Lamin A activity, and methods of influencing the expression of LMNA or LMNA variants are also described.

Abstract: In a preferred embodiment, a dual panel vehicle rear closure assembly is actuated by a cable drive assembly. Cables push a rear panel upward from a closed position to a second position above the roof. The cables may then push both panels forward toward a third position to open a rear opening in the roof. A motor pushes the cables through channels to slide the rear panel. Free ends of cables are guided into cable return tubes. Compression assist springs in the tubes are compressed by the cables when the rear panel is in its closed position and provide a counterbalance force to assist in opening the panel. The compression springs may be shorter than the full cable. The shorter springs can be made stronger for applying the balancing forces to the lower portion of the panel travel.

Abstract: In a preferred embodiment, a dual panel vehicle rear closure assembly is actuated by a cable drive assembly. Cables push a rear panel upward from a closed position to a second position above the roof. The cables may then push both panels forward toward a third position to open a rear opening in the roof. A motor pushes the cables through channels to slide the rear panel. Free ends of cables are guided into cable return tubes. Compression assist springs in the tubes are compressed by the cables when the rear panel is in its closed position and provide a counterbalance force to assist in opening the panel. The compression springs may be shorter than the full cable. The shorter springs can be made stronger for applying the balancing forces to the lower portion of the panel travel.

Abstract: There is provided a purified amino acid sequence selected from the group of Sequence ID No.: 3 and analogs thereof and mutations of Sequence ID No.: 3 which cause ataxia-telangiectasia. Also provided is a purified amino acid sequence as set forth in Sequence ID No.: 3 and analogs thereof.

Abstract: A probe capable of binding by homologous base pairing independently to a pair of gene regions bordering the upstream and downstream sides of a pair of infrequent restriction endonuclease sites separated by between about 20-2,000 kilibases on a section of linear DNA. The probe is produced, according to the method of the invention by digesting the DNA section to completion with the selected endonuclease, and ligating the resulting fragments under conditions which favor end-to-end circularization, and selecting digest fragments of the large circular molecules which have end to end junctions. Also disclosed are method for mapping and ordering the positions of such probes, using another set of linking probes which span such rate cutting sites.

Abstract: A junction-fragment DNA probe, a DNA probe cluster, and methods of preparing and using the probe and cluster to study gene localization and organization. The probe includes first and second gene segments which are derived from first and second, single-copy genomic-DNA gene regions, respectively, separated from one another, in the genomic DNA strand, by a selected distance of between about 20 and 2,000 kilobases. The two segments in the probe are connected at a jThe invention was supported in part by the National Institute of Health grant #NIH CA-30938 and the Government has certain rights to the invention.