Abstract: Provided herein are organ preservation solutions and methods of use thereof for preserving organs. In particular, provided herein are preservation solutions comprising a mineralocorticoid receptor antagonist, aldehyde dehydrogenase agonist, and/or histone deacetylase inhibitor, and methods of perfusing and storing an organ while awaiting transplantation or non-transplant surgery.

Abstract: Embodiments described herein relate, inter alia, to receiving one or more segments of a digital recording, wherein the one or segments include video and/or audio data of a surgical procedure; analyzing, via a video/audio understanding model, the one or more segments to (i) characterize a plurality of independent features associated with a technical skill and/or a non-technical practice that are evident in the one or more segments and (ii) determine a higher-order pattern based upon analyzing a group of at least two of the plurality of independent features; comparing the higher-order pattern to ratings data associated to outcomes following one or more surgical procedures; and automatically generating a quality score based upon the comparing, wherein the quality score is predictive of an assessment of the technical skill and/or non-technical practice.

Abstract: Provided herein are pharmaceutical compositions comprising valproic acid and methods of use thereof for the treatment and/or prevention of myocardial ischemia and/or infarction.

Abstract: Apparatus connects a pump to a chamber of a heart. A cuff attaches to the heart, the cuff having a flange portion for attaching to a surface of the heart and a sleeve portion extending from the flange portion. An inflow conduit has a first end for inserting into the heart, an intermediate portion for attaching to the sleeve portion of the cuff, and a second end for conveying blood from the heart to the pump. An expansion tool is releasably mounted with the inflow conduit to slide longitudinally within the inflow conduit. The expansion tool has a blunt tip for punching through the heart into the chamber at a distal end and a manual grip at a proximal end for pulling the expansion tool out from the inflow conduit.