Patents by Inventor Francis G. Fang

Francis G. Fang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for preparing immunological adjuvant
    Patent number: 8754236
    Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
    Type: Grant
    Filed: July 22, 2013
    Date of Patent: June 17, 2014
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Francis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Andre LesCarbeau, Xiang Niu, Kuo-Ming Wu
  • INTERMEDIATES FOR THE PREPARATION OF ANALOGS OF HALICHONDRIN B
    Publication number: 20140163242
    Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.
    Type: Application
    Filed: December 4, 2013
    Publication date: June 12, 2014
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Charles E. Chase, Francis G. Fang
  • COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT
    Publication number: 20140012011
    Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
    Type: Application
    Filed: July 22, 2013
    Publication date: January 9, 2014
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Francis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Andre LesCarbeau, Xiang Niu, Kuo-Ming Wu
  • Intermediates for the preparation of analogs of Halichondrin B
    Patent number: 8618313
    Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.
    Type: Grant
    Filed: April 23, 2013
    Date of Patent: December 31, 2013
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Farid Benayoud, Trevor L. Calkins, Charles E. Chase, William Christ, Francis G. Fang
  • INTERMEDIATES FOR THE PREPARATION OF ANALOGS OF HALICHONDRIN B
    Publication number: 20130237711
    Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.
    Type: Application
    Filed: April 23, 2013
    Publication date: September 12, 2013
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Farid BENAYOUD, Trevor Lee Calkins, Charles E. Chase, William Christ, Francis G. Fang
  • Compounds for preparing immunological adjuvant
    Patent number: 8519170
    Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: August 27, 2013
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Francis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Andre Lescarbeau, Xiang Niu, Kuo-Ming Wu
  • Intermediates in the synthesis zearalenone macrolide analogs
    Patent number: 8507696
    Abstract: Disclosed herein are methods and intermediates useful in the preparation of macrolides, e.g., compounds of formula (IV), wherein R1-R12 are as defined herein.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: August 13, 2013
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Francis G. Fang, Xiang Niu, Matthew J. Schnaderbeck
  • Intermediates for the preparation of analogs of halichondrin B
    Patent number: 8445701
    Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: May 21, 2013
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Brian Austad, Charles E. Chase, Francis G. Fang, Marc Pesant
  • COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS
    Publication number: 20130123519
    Abstract: In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts thereof, e.g., eribulin mesylate.
    Type: Application
    Filed: January 7, 2013
    Publication date: May 16, 2013
    Inventors: Atsushi Endo, Charles E. Chase, Francis G. Fang
  • Intermediates and methods for making zearalenone macrolide analogs
    Patent number: 8350059
    Abstract: Disclosed herein are methods and intermediates useful in the preparation of macrolides, e.g., compounds of formula (IV) wherein R1-R12 are as defined herein.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: January 8, 2013
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Roch Boivin, Silvio A. Campagna, Hong Du, Francis G. Fang, Thomas Horstmann, Charles-Andre Lemelin, Jing Li, Pamela McGuinness, Xiang Niu, Matthew J. Schnaderbeck, Kevin (kuo-ming) Wu, Xiaojie (jeff) Zhu
  • Compounds useful in the synthesis of halichondrin B analogs
    Patent number: 8350067
    Abstract: In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts thereof, e.g., eribulin mesylate.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: January 8, 2013
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Atsushi Endo, Charles E. Chase, Francis G. Fang
  • INTERMEDIATES FOR THE PREPARATION OF ANALOGS OF HALICHONDRIN B
    Publication number: 20120309988
    Abstract: Intermediates and methods of their use in the synthesis of anslogs of halichondrin B are provided.
    Type: Application
    Filed: May 21, 2012
    Publication date: December 6, 2012
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Brian Austad, Charles E. Chase, Francis G. Fang, Marc Pesant
  • COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS
    Publication number: 20120289718
    Abstract: In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts thereof, e.g., eribulin mesylate.
    Type: Application
    Filed: May 22, 2012
    Publication date: November 15, 2012
    Inventors: Atsushi ENDO, Charles E. CHASE, Francis G. FANG
  • COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT
    Publication number: 20120232298
    Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
    Type: Application
    Filed: May 10, 2012
    Publication date: September 13, 2012
    Inventors: Francis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Andre Lescarbeau, Xiang Niu, Kuo-Ming Wu
  • Compounds useful in the synthesis of halichondrin B analogs
    Patent number: 8203010
    Abstract: In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts thereof, e.g., eribulin mesylate.
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: June 19, 2012
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Atsushi Endo, Charles E. Chase, Francis G. Fang
  • Compounds for preparing immunological adjuvant
    Patent number: 8198474
    Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates useful for implementing the inventive methods.
    Type: Grant
    Filed: February 2, 2010
    Date of Patent: June 12, 2012
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Francis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Andre Lescarbeau, Xiang Niu, Kuo-Ming Wu
  • INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS
    Publication number: 20120095242
    Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.
    Type: Application
    Filed: December 22, 2011
    Publication date: April 19, 2012
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Charles Chase, Atsushi Endo, Francis G. Fang, Jing Li
  • INTERMEDIATES FOR THE PREPARATION OF ANALOGS OF HALICHONDRIN B
    Publication number: 20120029213
    Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.
    Type: Application
    Filed: June 29, 2011
    Publication date: February 2, 2012
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Brian Austad, Farid Benayoud, Trevor Calkins, Silvio Campagna, Charles E. Chase, William Christ, Francis G. Fang, Yongbo Hu, Bryan M. Lewis, Marc Pesant, Matthew Schnaderbeck, Gordon Wilkie, Xiaojie Zhu
  • Reagents and methods for the beta-keto amide synthesis of a synthetic precursor to immunological adjuvant E6020
    Patent number: 8049023
    Abstract: This invention relates to the synthesis for a precursor of E6020, compound 26, via a ?-keto amide alcohol intermediate, compound 22. The synthesis reacts compound 22 with compound 25 and the resultant intermediate is oxidized to produce compound 26, the precursor to E6020. Compounds 22 and 25, and their crystalline forms, represent separate embodiments of the invention. The invention also relates to compounds of formulas (3) and (4) and processes for their preparation. The ?-keto amide alcohol intermediate compound 22 is a compound of formula (3). Compound 25 is a compound of formula (4).
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: November 1, 2011
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Bruce DeCosta, Francis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Xiang Niu, Kuo-Ming Wu
  • INTERMEDIATES AND METHODS FOR MAKING ZEARALENONE MACROLIDE ANALOGS
    Publication number: 20110237805
    Abstract: Disclosed herein are methods and intermediates useful in the preparation of macrolides, e.g., compounds of formula (IV) wherein R1-R12 are as defined herein.
    Type: Application
    Filed: December 8, 2008
    Publication date: September 29, 2011
    Applicant: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Roch Boivin, Silvio A. Campagna, Hong Du, Francis G. Fang, Thomas Horstmann, Charles-Andre Lemelin, Jing Li, Pamela Mcguinness, Xiang Niu, Matthew J. Schnaderbeck, Kevin (kuo-ming) Wu, Xiaojie (Jeff) Zhu