Patents by Inventor Francis Gerard Fang

Francis Gerard Fang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of a camptothecin derivative by intramolecular cyclisation
    Patent number: 6821982
    Abstract: The present invention relates to a method for the preparation for camptothecin and camptothecin-like compounds and to novel intermediates used in this preparation. In particular, the invention provides a process for the preparation of the camptothecin derivative of formula (I′) known by the chemical name “7-(4-methylpiperazino-methylene)-10,11-ethylenedioxy-20(R,S)-camptothecin”, which comprises cyclising the compound of formula (II′), wherein X is halogen, particularly chloro, bromo, or iodo; and when the compound of formula (I′) is obtained as a mixture of enantiomers optionally resolving the mixture to obtain the desired enantiomer; and/or if desired, converting the resulting compound of formula (I′) or a salt thereof into a physiologically acceptable salt or solvate thereof.
    Type: Grant
    Filed: March 24, 2003
    Date of Patent: November 23, 2004
    Assignee: OSI Pharmaceuticals, Inc.
    Inventors: Francis Gerard Fang, Edward McDonald Huie, Shiping Xie, Daniel L. Comins
  • Method for preparing camptothecin derivatives
    Patent number: 6716982
    Abstract: The present invention relates to a process for preparing camptothecin and camptothecin analogs of Formula (I) from compounds of Formula (II) and to novel intermediates useful in their preparation, wherein R1 to R6 represent various substituents.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: April 6, 2004
    Assignee: OSI Pharmaceuticals, Inc.
    Inventors: Francis Gerard Fang, Shiping Xie
  • Preparation of a camptothecin derivative by intramolecular cyclisation
    Publication number: 20030204088
    Abstract: The present invention relates to a method for the preparation for camptothecin and camptothecin-like compounds and to novel intermediates used in this preparation. In particular, the invention provides a process for the preparation of the camptothecin derivative of formula (I′) known by the chemical name “7-(4-methylpiperazino-methylene)-10,11-ethylenedioxy-20(R,S)-camptothecin”, which comprises cyclising the compound of formula (II′), wherein X is halogen, particularly chloro, bromo, or iodo; and when the compound of formula (I′) is obtained as a mixture of enantiomers optionally resolving the mixture to obtain the desired enantiomer; and/or if desired, converting the resulting compound of formula (I′) or a salt thereof into a physiologically acceptable salt or solvate thereof.
    Type: Application
    Filed: March 24, 2003
    Publication date: October 30, 2003
    Applicant: OSI Pharmaceuticals, Inc.
    Inventors: Francis Gerard Fang, Edward McDonald Huie, Shiping Xie, Daniel L. Comins
  • Preparation of a camptothecin derivative by intramolecular cyclisation
    Patent number: 6559309
    Abstract: The present invention relates to a method for the preparation for camptothecin and camptothecin-like compounds and to novel intermediates used in this preparation. In particular, the invention provides a process for the preparation of the camptothecin derivative of formula (I′) known by the chemical name “7-(4-methylpiperazino-methylene)-10,11-ethylenedioxy-20(R,S)-camptothecin”, which comprises cyclising the compound of formula (II′), wherein X is halogen, particularly chloro, bromo, or iodo; and when the compound of formula (I′) is obtained as a mixture of enantiomers optionally resolving the mixture to obtain the desired enantiomer; and/or if desired, converting the resulting compound of formula (I′) or a salt thereof into a physiologically acceptable salt or solvate thereof.
    Type: Grant
    Filed: September 13, 2002
    Date of Patent: May 6, 2003
    Assignees: OSI Pharmaceuticals, Inc., North Carolina State University
    Inventors: Francis Gerard Fang, Edward McDonald Huie, Shiping Xie, Daniel L. Comins
  • Preparation of a camptothecin derivative by intramolecular cyclisation
    Publication number: 20030045719
    Abstract: The present invention relates to a method for the preparation for camptothecin and camptothecin-like compounds and to novel intermediates used in this preparation. In particular, the invention provides a process for the preparation of the camptothecin derivative of formula (I′) known by the chemical name “7-(4-methylpiperazinomethylene)-10,11-ethylenedioxy-20(R,S)-camptothecin”, which comprises cyclising the compound of formula (II′), wherein X is halogen, particularly chloro, bromo, or iodo; and when the compound of formula (I′) is obtained as a mixture of enantiomers optionally resolving the mixture to obtain the desired enantiomer; and/or if desired, converting the resulting compound of formula (I′) or a salt thereof into a physiologically acceptable salt or solvate thereof.
    Type: Application
    Filed: September 13, 2002
    Publication date: March 6, 2003
    Applicant: OSI Pharmaceuticals, Inc.
    Inventors: Francis Gerard Fang, Edward McDonald Huie, Shiping Xie, Daniel L. Comins
  • Preparation of a camptothecin derivative by intramolecular cyclization
    Patent number: 6462196
    Abstract: The present invention relates to a method for the preparation for camptothecin and camptothecin-like compounds and to novel intermediates used in this preparation. In particular, the invention provides a process for the preparation of the camptothecin derivative of formula (I′) known by the chemical name “7-(4-methylpiperazino-methylene)-10,11-ethylenedioxy-20(R,S)-camptothecin”, which comprises cyclising the compound of formula (II′), wherein X is halogen, particularly chloro, bromo, or iodo; and when the compound of formula (I′) is obtained as a mixture of enantiomers optionally resolving the mixture to obtain the desired enantiomer; and/or if desired, converting the resulting compound of formula (I′) or a salt thereof into a physiologically acceptable salt or solvate thereof.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: October 8, 2002
    Assignee: OSI Pharmaceuticals, Inc.
    Inventors: Francis Gerard Fang, Edward McDonald Huie, Shiping Xie, Daniel L. Comins
  • Method for preparing camptothecin derivatives
    Publication number: 20010051724
    Abstract: The present invention relates to a process for preparing camptothecin and camptothecin analogs of Formula (I) from compounds of Formula (II) and to novel intermediates useful in their preparation, 1
    Type: Application
    Filed: July 11, 2001
    Publication date: December 13, 2001
    Applicant: Gilead Sciences, Inc.
    Inventors: Francis Gerard Fang, Shiping Xie
  • Method for preparing camptothecin derivatives
    Patent number: 6284891
    Abstract: The present invention relates to a process for preparing camptothecin and camptothecin analogs of Formula (I) from compounds of Formula (II) and to novel intermediates useful in their preparation, wherein R1 to R6 represent various substituents.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: September 4, 2001
    Assignee: Gilead Sciences, Inc.
    Inventors: Francis Gerard Fang, Shiping Xie
  • Method for preparing camptothecin derivatives
    Patent number: 6143891
    Abstract: The present invention relates to a process for preparing camptothecin and camptothecin analogs of Formula (I) from compounds of Formula (II) and to novel intermediates useful in their preparation, ##STR1## wherein R.sub.1 to R.sub.6 represent various substituents.
    Type: Grant
    Filed: May 14, 1998
    Date of Patent: November 7, 2000
    Assignee: Glaxo Wellcome Inc.
    Inventors: Francis Gerard Fang, Shiping Xie
  • Preparation of a camptothecin derivative by intramolecular cyclisation
    Patent number: 6063923
    Abstract: The present invention relates to a method for the preparation of camptothecin and camptothecin-like compounds and to novel intermediates used in this preparation. In particular, the invention provides a process for the preparation of the camptothecin derivative of formula (I') known by the chemical name "7-(4-methylpiperazino-methylene)-10,11-ethylenedioxy-20(R,S)-camptothecin ", which comprises cyclising the compound of formula (II'), wherein X is halogen, particularly chloro, bromo, or iodo; and when the compound of formula (I') is obtained as a mixture of enantiomers optionally resolving the mixture to obtain the desired enantiomer, and/or if desired, converting the resulting compound of formula (I') or a salt thereof into a physiologically acceptable salt or solvate thereof.
    Type: Grant
    Filed: November 1, 1996
    Date of Patent: May 16, 2000
    Assignees: Glaxo Wellcome Inc., North Carolina State University
    Inventors: Francis Gerard Fang, Edward McDonald Huie, Shiping Xie, Daniel L. Comins
  • Method of removing heavy metal contaminants from organic compounds
    Patent number: 5840898
    Abstract: A process for removal of heavy metal contaminants from organic compounds, especially campthothecin analogs.
    Type: Grant
    Filed: November 1, 1996
    Date of Patent: November 24, 1998
    Assignee: Glaxo Wellcome, Inc.
    Inventors: Francis Gerard Fang, Melissa Williams Lowery, Shiping Xie