Abstract: Methods are provided for treating a subject with for an intracellular pathogen infection, by administering an agent that masks or otherwise blocks phosphatidylserine on the pathogen cell surface.

Abstract: The present invention represents an electromagnet-based pickup & inspection tool/device for locating and the recovery of ferrous and unique to the present invention, nonferrous objects with a, and also unique to the present invention, an attachable gripping device, from confined spaces, such as engine compartments. Additional unique features of the present EMRID invention is the, use of LED illumination for wide area viewing, and a WIFI micro endoscope type of video camera for enhanced search & inspection capabilities, inclusive of, built-in LEDs.

Abstract: A system for and a method of determining that a detoured trip is to be presented to a potential passenger. The method comprises receiving a rideshare request; generating a rideshare request parameter; and accessing, from a database, trip filtering parameters associated with trips. The method further comprises determining that at least one of the trips is a candidate for which a detour route is to be computed based on an analysis of the rideshare request parameter and a corresponding trip filtering parameter associated with the at least one of the trips; causing to compute, for the at least one of the trips determined as being the candidate for which the detour route is to be computed, a detoured trip; and determining that the detoured trip is to be presented to the potential passenger by analysing the deviation value of the detoured trip and the deviation threshold.

Abstract: The invention LIFT STOP III is a mechanical device that is made to lift a doorstop from its down position to its full up position. The LIFT STOP III is used in conjunction with a doorstop.

Abstract: A modular eyewear apparatus includes a frame member having left and right socket portions each having a generally circular rim defining an interior void, respectively, and being connected by a bridge portion, the left and the right socket portion having a temple connector extending rearwardly from a respective rim. A lens holding member has a pair of adjacent rim sections selectively coupled to the rims of the left and the right socket portions, respectively. The eyewear apparatus includes proximal and distal ends, respectively, each proximal end being selectively coupled to a respective temple connector such that the temple members are interchangeable. The configurations of the selected members themselves enable them to be quickly and efficiently released from an assembly or to be interchangeably arranged into a new assembly as described above.

Abstract: A method performed by a computing system. Embodiments of the method include shifting source data by a shift amount and encrypting the shifted data with an encryption key to produce encrypted data. An encryption package is produced by removing a portion of the encrypted data. Decryption data is generated that includes the shift amount, the encryption key, the location in the encrypted data from which the data was removed, and the data that was removed. Copies of the encryption package are sent to remote client computing devices and the system waits until a decryption time. At the decryption time, copies of the decryption data are sent to the client computing devices, which are each configured to decrypt the encryption package using the decryption data to obtain the information of the source data at substantially the same time.

Abstract: A method, apparatus, system, and signal-bearing medium that in an embodiment determine whether to log an exception based on whether the exception has already occurred. In an embodiment, exceptions that repeatedly occur at the same source and location within the source are logged on the first occurrence, and not logged thereafter. In this way, data can be saved about the exception, yet system resources are not consumed by repeated logging.

Abstract: A web-based supply chain system manages internal users, suppliers, and external customers to improve business productivity. The web-based system includes a server, at least one computer, and a network that couples the computer to the server. The server is configured with a database of supply chain business information. The server also includes a plurality of user interfaces that are associated with business transactional applications. Furthermore, the server allows a user to access and retrieve the supply chain business transactional applications. The data is available for users, suppliers, and customers to view through a secure connection to a business entity's server system.

Abstract: Apparatus (10) for the removal of a needle assembly A having a needle hub H which is screw-threadedly engaged with a syringe S, said apparatus (10) comprising a housing (11) having an opening (16) for insertion of the needle assembly A and adjacent portion of the syringe, a socket (19) mounted within the housing (11) in alignment with the opening (16) with a cavity (22) shaped to receive the hub H and a coaxial through-bore (23) to accommodate the needle. The socket (19) holds the hub rotationally fast allowing the syringe S and needle assembly A to be unscrewed, and an ejector means (51) located in the housing ejects the unscrewed needle assembly A from the socket (19) into a collection container (42) located within the housing (11).

Abstract: A method, apparatus, system, and signal-bearing medium that in an embodiment determine whether to log an exception based on whether the exception has already occurred. In an embodiment, exceptions that repeatedly occur at the same source and location within the source are logged on the first occurrence, and not logged thereafter. In this way, data can be saved about the exception, yet system resources are not consumed by repeated logging.

Abstract: The present invention relates to a method for the preparation for camptothecin and camptothecin-like compounds and to novel intermediates used in this preparation. In particular, the invention provides a process for the preparation of the camptothecin derivative of formula (I′) known by the chemical name “7-(4-methylpiperazino-methylene)-10,11-ethylenedioxy-20(R,S)-camptothecin”, which comprises cyclising the compound of formula (II′), wherein X is halogen, particularly chloro, bromo, or iodo; and when the compound of formula (I′) is obtained as a mixture of enantiomers optionally resolving the mixture to obtain the desired enantiomer; and/or if desired, converting the resulting compound of formula (I′) or a salt thereof into a physiologically acceptable salt or solvate thereof.

Abstract: A circular filament lamp comprises a filament supported within an envelope which comprises a tube formed as the major part of a circle. The ends of the tube terminate in pinch seals through which extend current carrying assemblies connected to the filament. The pinch seals overlap one another circumferentially of the lamp, and are offset from one another on either side of a plane containing the axis of the filament.

Abstract: The present invention relates to a process for preparing camptothecin and camptothecin analogs of Formula (I) from compounds of Formula (II) and to novel intermediates useful in their preparation, wherein R1 to R6 represent various substituents.

Abstract: A circular filament lamp comprises a filament supported within an envelope which comprises a tube formed as the major part of a circle. The ends of the tube terminate in pinch seals through which extend current carrying assemblies connected to the filament. The pinch seals overlap one another circumferentially of the lamp, and are offset from one another on either side of a plane containing the axis of the filament.

Abstract: The present invention relates to a method for the preparation for camptothecin and camptothecin-like compounds and to novel intermediates used in this preparation. In particular, the invention provides a process for the preparation of the camptothecin derivative of formula (I′) known by the chemical name “7-(4-methylpiperazino-methylene)-10,11-ethylenedioxy-20(R,S)-camptothecin”, which comprises cyclising the compound of formula (II′), wherein X is halogen, particularly chloro, bromo, or iodo; and when the compound of formula (I′) is obtained as a mixture of enantiomers optionally resolving the mixture to obtain the desired enantiomer; and/or if desired, converting the resulting compound of formula (I′) or a salt thereof into a physiologically acceptable salt or solvate thereof.

Abstract: The present invention relates to a method for the preparation for camptothecin and camptothecin-like compounds and to novel intermediates used in this preparation. In particular, the invention provides a process for the preparation of the camptothecin derivative of formula (I′) known by the chemical name “7-(4-methylpiperazino-methylene)-10,11-ethylenedioxy-20(R,S)-camptothecin”, which comprises cyclising the compound of formula (II′), wherein X is halogen, particularly chloro, bromo, or iodo; and when the compound of formula (I′) is obtained as a mixture of enantiomers optionally resolving the mixture to obtain the desired enantiomer; and/or if desired, converting the resulting compound of formula (I′) or a salt thereof into a physiologically acceptable salt or solvate thereof.

Abstract: The present invention relates to a method for the preparation for camptothecin and camptothecin-like compounds and to novel intermediates used in this preparation. In particular, the invention provides a process for the preparation of the camptothecin derivative of formula (I′) known by the chemical name “7-(4-methylpiperazinomethylene)-10,11-ethylenedioxy-20(R,S)-camptothecin”, which comprises cyclising the compound of formula (II′), wherein X is halogen, particularly chloro, bromo, or iodo; and when the compound of formula (I′) is obtained as a mixture of enantiomers optionally resolving the mixture to obtain the desired enantiomer; and/or if desired, converting the resulting compound of formula (I′) or a salt thereof into a physiologically acceptable salt or solvate thereof.

Abstract: A web-based supply chain system manages internal users, suppliers, and external customers to improve business productivity. The web-based system includes a server, at least one computer, and a network that couples the computer to the server. The server is configured with a database of supply chain business information. The server also includes a plurality of user interfaces that are associated with business transactional applications. Furthermore, the server allows a user to access and retrieve the supply chain business transactional applications. The data is available for users, suppliers, and customers to view through a secure connection to a business entity's server system.

Abstract: The present invention relates to a method for the preparation for camptothecin and camptothecin-like compounds and to novel intermediates used in this preparation. In particular, the invention provides a process for the preparation of the camptothecin derivative of formula (I′) known by the chemical name “7-(4-methylpiperazino-methylene)-10,11-ethylenedioxy-20(R,S)-camptothecin”, which comprises cyclising the compound of formula (II′), wherein X is halogen, particularly chloro, bromo, or iodo; and when the compound of formula (I′) is obtained as a mixture of enantiomers optionally resolving the mixture to obtain the desired enantiomer; and/or if desired, converting the resulting compound of formula (I′) or a salt thereof into a physiologically acceptable salt or solvate thereof.

Abstract: The present invention relates to a process for preparing camptothecin and camptothecin analogs of Formula (I) from compounds of Formula (II) and to novel intermediates useful in their preparation, 1