Patents by Inventor Francis Goudaliez
Francis Goudaliez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230321148Abstract: A sterilised platelet lysate obtained with a method for sterilising a platelet lysate in the liquid state comprising at least the endogenous growth factors TGF-beta 1, EGF, PDGF-AB, IGF-1, VEGF and bFGF. The method comprising freezing the liquid platelet lysate in order to obtain a frozen platelet lysate, and irradiating the frozen platelet lysate with ionising radiation in order to obtain a sterilised platelet lysate, the irradiation being adapted so as to preserve at least 80% of the concentration of at least one of the endogenous growth factors chosen from the group consisting of TGF-beta 1, EGF, PDGF-AB, IGF-1 and VEGF.Type: ApplicationFiled: June 2, 2023Publication date: October 12, 2023Applicant: Maco PharmaInventors: Bruno Delorme, Sabrina Viau, Francis Goudaliez
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Patent number: 11690875Abstract: A method for sterilising a platelet lysate in the liquid state comprising at least the endogenous growth factors TGF-beta 1, EGF, PDGF-AB, IGF-1, VEGF and bFGF. The method comprising freezing the liquid platelet lysate in order to obtain a frozen platelet lysate, and irradiating the frozen platelet lysate with ionising radiation in order to obtain a sterilised platelet lysate, the irradiation being adapted so as to preserve at least 80% of the concentration of at least one of the endogenous growth factors chosen from the group consisting of TGF-beta 1, EGF, PDGF-AB, IGF-1 and VEGF.Type: GrantFiled: February 19, 2021Date of Patent: July 4, 2023Assignee: Maco PharmaInventors: Bruno Delorme, Sabrina Viau, Francis Goudaliez
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Publication number: 20210196758Abstract: A method for sterilising a platelet lysate in the liquid state comprising at least the endogenous growth factors TGF-beta 1, EGF, PDGF-AB, IGF-1, VEGF and bFGF. The method comprising freezing the liquid platelet lysate in order to obtain a frozen platelet lysate, and irradiating the frozen platelet lysate with ionising radiation in order to obtain a sterilised platelet lysate, the irradiation being adapted so as to preserve at least 80% of the concentration of at least one of the endogenous growth factors chosen from the group consisting of TGF-beta 1, EGF, PDGF-AB, IGF-1 and VEGF.Type: ApplicationFiled: February 19, 2021Publication date: July 1, 2021Applicant: Maco PharmaInventors: Bruno Delorme, Sabrina Viau, Francis Goudaliez
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Patent number: 10946046Abstract: A method for sterilising a platelet lysate in the liquid state comprising at least the endogenous growth factors TGF-beta 1, EGF, PDGF-AB, IGF-1, VEGF and bFGF. The method comprising freezing the liquid platelet lysate in order to obtain a frozen platelet lysate, and irradiating the frozen platelet lysate with ionising radiation in order to obtain a sterilised platelet lysate, the irradiation being adapted so as to preserve at least 80% of the concentration of at least one of the endogenous growth factors chosen from the group consisting of TGF-beta 1, EGF, PDGF-AB, IGF-1 and VEGF.Type: GrantFiled: May 27, 2016Date of Patent: March 16, 2021Assignee: Maco PharmaInventors: Bruno Delorme, Sabrina Viau, Francis Goudaliez
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Publication number: 20180289744Abstract: A method for sterilising a platelet lysate in the liquid state comprising at least the endogenous growth factors TGF-beta 1, EGF, PDGF-AB, IGF-1, VEGF and bFGF. The method comprising freezing the liquid platelet lysate in order to obtain a frozen platelet lysate, and irradiating the frozen platelet lysate with ionising radiation in order to obtain a sterilised platelet lysate, the irradiation being adapted so as to preserve at least 80% of the concentration of at least one of the endogenous growth factors chosen from the group consisting of TGF-beta 1, EGF, PDGF-AB, IGF-1 and VEGF.Type: ApplicationFiled: May 27, 2016Publication date: October 11, 2018Applicant: Maco PharmaInventors: Bruno Delorme, Sabrina Viau, Francis Goudaliez
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Patent number: 10058646Abstract: The present invention relates to a blood bag system, a method for its manufacture, and a process for reducing pathogens and leucocytes in biological fluids in particular in therapeutic quantities of platelet concentrates (PC) contained in the blood bag system, using UV-light and agitation, wherein part of the plasma of the PC is optionally exchanged against a platelet additive solution.Type: GrantFiled: March 6, 2017Date of Patent: August 28, 2018Assignee: MACO PHARMA S.A.Inventors: Wolfram Hubert Walker, Frank Tolksdorf, Thierry Verpoort, Francis Goudaliez
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Publication number: 20170232163Abstract: The present invention relates to a blood bag system, a method for its manufacture, and a process for reducing pathogens and leucocytes in biological fluids in particular in therapeutic quantities of platelet concentrates (PC) contained in the blood bag system, using UV-light and agitation, wherein part of the plasma of the PC is optionally exchanged against a platelet additive solution.Type: ApplicationFiled: March 6, 2017Publication date: August 17, 2017Applicant: MACO PHARMA S.A.Inventors: Wolfram Hubert Walker, Frank Tolksdorf, Thierry Verpoort, Francis Goudaliez
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Irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid and process
Patent number: 9320817Abstract: The invention relates to an irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid such as a platelet suspension and/or plasma comprising: a casing (2), a support member (3) for carrying at least one irradiation bag (19) containing the biological fluid, a light source (4) comprising two banks of light (5, 6) disposed above and below the support member (3), and an agitating system (25) for moving the support member (3), the light source generating UVC light of suitable intensity to inactivate pathogens and/or leukocytes and the agitation system moving the support member in an orbital path with predetermined amplitude and rotational frequency suitable to expose the whole biological fluid to UVC.Type: GrantFiled: July 11, 2014Date of Patent: April 26, 2016Assignee: MACO PHARMA S.A.Inventors: Wolfram Hubert Walker, Frank Tolksdorf, Thierry Verpoort, Francis Goudaliez, Maurice Behague, Arnaud Chavatte -
Patent number: 8986237Abstract: A filtering unit for removing a virucidal substance from a biological fluid including an outer casing having at least one input aperture and at least one output aperture. The outer casing including a filter medium, which separates the filtration unit into an input compartment and an output compartment. The filter medium includes at least one hydrophilic material able to absorb or adsorb the virucidal substance. The at least one hydrophilic material includes either porous non-woven material or a porous membrane.Type: GrantFiled: April 19, 2011Date of Patent: March 24, 2015Assignee: MacopharmaInventors: Francis Goudaliez, Thierry Verpoort
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IRRADIATION APPARATUS FOR INACTIVATING PATHOGENS AND/OR LEUKOCYTES IN A BIOLOGICAL FLUID AND PROCESS
Publication number: 20150030500Abstract: The invention relates to an irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid such as a platelet suspension and/or plasma comprising: a casing (2), a support member (3) for carrying at least one irradiation bag (19) containing the biological fluid, a light source (4) comprising two banks of light (5, 6) disposed above and below the support member (3), and an agitating system (25) for moving the support member (3), the light source generating UVC light of suitable intensity to inactivate pathogens and/or leukocytes and the agitation system moving the support member in an orbital path with predetermined amplitude and rotational frequency suitable to expose the whole biological fluid to UVC.Type: ApplicationFiled: July 11, 2014Publication date: January 29, 2015Applicant: MACO PHARMA S.A.Inventors: Wolfram Hubert Walker, Frank Tolksdorf, Thierry Verpoort, Francis Goudaliez, Maurice Behague, Arnaud Chavatte -
Irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid and process
Patent number: 8778263Abstract: The invention relates to an irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid such as a platelet suspension and/or plasma comprising: a casing (2), a support member (3) for carrying at least one irradiation bag (19) containing the biological fluid, a light source (4) comprising two banks of light (5, 6) disposed above and below the support member (3), and an agitating system (25) for moving the support member (3), the light source generating UVC light of suitable intensity to inactivate pathogens and/or leukocytes and the agitation system moving the support member in an orbital path with predetermined amplitude and rotational frequency suitable to expose the whole biological fluid to UVC.Type: GrantFiled: June 17, 2008Date of Patent: July 15, 2014Assignee: Maco Pharma S.A.Inventors: Wolfram Hubert Walker, Frank Tolksdorf, Thierry Verpoort, Francis Goudaliez, Maurice Behague, Arnaud Chavatte -
Patent number: 8388597Abstract: The invention includes a bag system for collecting a biological fluid, in particular blood. The system includes a device for collecting the fluid which is in fluid communication with at least one fluid collection bag, and a device for sampling the fluid to be collected which includes at least one sampling receptacle. The sampling device includes a device for transferring the fluid from the bag system into the sampling receptacle or receptacles, in which the transfer device is provided with a device for associating the receptacle or receptacles. The transfer device may be arranged to allow the support of the receptacle or receptacles in a standby position, the guidance of the receptacle or receptacles to a transfer position and, after transfer, the dissociation of the receptacle or receptacles from the bag system.Type: GrantFiled: October 27, 2009Date of Patent: March 5, 2013Assignee: MacopharmaInventors: Sylvie Demay, Francis Goudaliez, Thierry Verpoort
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Publication number: 20110192798Abstract: A filtering unit for removing a virucidal substance from a biological fluid including an outer casing having at least one input aperture and at least one output aperture. The outer casing including a filter medium, which separates the filtration unit into an input compartment and an output compartment. The filter medium includes at least one hydrophilic material able to absorb or adsorb the virucidal substance. The at least one hydrophilic material includes either porous non-woven material or a porous membrane.Type: ApplicationFiled: April 19, 2011Publication date: August 11, 2011Inventors: Francis Goudaliez, Thierry Verpoort
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Patent number: 7879000Abstract: The invention concerns a method of collecting a biological fluid, in particular blood, with an anticoagulant and/or preservation solution added, in which the biological fluid is collected by natural flow and the anticoagulant and/or preservation solution is added by pumping, the method making provision for measuring the flow of fluid collected and slaving the pumping speed to the measured flow, so as to obtain continuously during collection a given ratio between the quantity of fluid collected and the quantity of anticoagulant and/or preservation solution added. The invention also concerns a collection machine and bag system for implementing the method.Type: GrantFiled: December 31, 2003Date of Patent: February 1, 2011Assignee: MacopharmaInventors: Maurice Behague, Francis Goudaliez, Thierry Verpoort
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Patent number: 7766854Abstract: A biological fluid collection system including a collecting device, a collecting container, a first channel connecting the two, a sampling bag, a second channel connecting the sampling bag and the first tube and at least one substantially irreversible closure device in an open position on at least the first or second channel. The biological fluid may be blood. A method of collecting biological fluid such as blood using the system so that fluid in the sampling bag is substantially irreversibly prevented from entering the collecting container.Type: GrantFiled: December 6, 2007Date of Patent: August 3, 2010Assignee: MacoPharmaInventors: Francis Goudaliez, Thierry Verpoort
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IRRADIATION APPARATUS FOR INACTIVATING PATHOGENS AND/OR LEUKOCYTES IN A BIOLOGICAL FLUID AND PROCESS
Publication number: 20100178200Abstract: The invention relates to an irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid such as a platelet suspension and/or plasma comprising: a casing (2), a support member (3) for carrying at least one irradiation bag (19) containing the biological fluid, a light source (4) comprising two banks of light (5, 6) disposed above and below the support member (3), and an agitating system (25) for moving the support member (3), the light source generating UVC light of suitable intensity to inactivate pathogens and/or leukocytes and the agitation system moving the support member in an orbital path with predetermined amplitude and rotational frequency suitable to expose the whole biological fluid to UVC.Type: ApplicationFiled: June 17, 2008Publication date: July 15, 2010Applicant: MACO PHARMA S.A.Inventors: Wolfram Hubert Walker, Frank Tolksdorf, Thierry Verpoort, Francis Goudaliez, Maurice Behague, Arnaud Chavatte -
Publication number: 20100133203Abstract: The present invention relates to a blood bag system, a method for its manufacture, and a process for reducing pathogens and leucocytes in biological fluids in particular in therapeutic quantities of platelet concentrates (PC) contained in the blood bag system, using UV-light and agitation, wherein part of the plasma of the PC is optionally exchanged against a platelet additive solution.Type: ApplicationFiled: June 22, 2007Publication date: June 3, 2010Inventors: Wolfram Hubert Walker, Frank Tolksdorf, Thierry Verpoort, Francis Goudaliez
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Publication number: 20100049089Abstract: The invention includes a bag system for collecting a biological fluid, in particular blood. The system includes a device for collecting the fluid which is in fluid communication with at least one fluid collection bag, and a device for sampling the fluid to be collected which includes at least one sampling receptacle. The sampling device includes a device for transferring the fluid from the bag system into the sampling receptacle or receptacles, in which the transfer device is provided with a device for associating the receptacle or receptacles. The transfer device may be arranged to allow the support of the receptacle or receptacles in a standby position, the guidance of the receptacle or receptacles to a transfer position and, after transfer, the dissociation of the receptacle or receptacles from the bag system.Type: ApplicationFiled: October 27, 2009Publication date: February 25, 2010Applicant: MacoPharmaInventors: Sylvie Demay, Francis Goudaliez, Thierry Verpoort
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Patent number: 7621298Abstract: A recipient has a body designed to contain a fluid and an orifice by which the fluid may be introduced into the body. The recipient is equipped with a system for the sterile transfer of the fluid from inside the body. The transfer system comprises a deformable and impervious wall, wherein the wall is positioned with respect to the recipient so that it forms a closed and sterile space inside which the orifice is located, a fluid communication device between the closed space and the outside of the recipient, wherein the device may be handled without compromising the sterility, and a seal structure associated with the orifice, wherein the seal structure is at least partially located inside the closed space so that it may be moved between an open position and a closed position of the orifice.Type: GrantFiled: October 24, 2007Date of Patent: November 24, 2009Assignee: Maco Pharma, S.A.Inventors: Francis Goudaliez, Thierry Verpoort
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Patent number: 7618407Abstract: The invention includes a bag system for collecting a biological fluid, in particular blood. The system includes a device for collecting the fluid which is in fluid communication with at least one fluid collection bag, and a device for sampling the fluid to be collected which includes at least one sampling receptacle. The sampling device includes a device for transferring the fluid from the bag system into the sampling receptacle or receptacles, in which the transfer device is provided with a device for associating the receptacle or receptacles. The transfer device may be arranged to allow the support of the receptacle or receptacles in a standby position, the guidance of the receptacle or receptacles to a transfer position and, after transfer, the dissociation of the receptacle or receptacles from the bag system.Type: GrantFiled: December 10, 2007Date of Patent: November 17, 2009Assignee: MacoPharmaInventors: Sylvie Demay, Francis Goudaliez, Thierry Verpoort