Patents by Inventor Francis Hubler

Francis Hubler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C5A receptor modulators
    Patent number: 11739070
    Abstract: The present invention relates to derivatives of formula (I) wherein ring A, X, Y, Z, R1, R2, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: August 29, 2023
    Assignee: IDORSIA PHARMACEUTICALS LTD.
    Inventors: Sylvie Froidevaux, Francis Hubler, Mark Murphy, Dorte Renneberg, Simon Stamm
  • C5a receptor modulators
    Patent number: 11685729
    Abstract: The present invention relates to derivatives of formula (I) wherein Ring A, W, X, Y, Z, R1, R2, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: June 27, 2023
    Assignee: IDORSIA PHARMACEUTICALS LTD.
    Inventors: Sylvie Froidevaux, Francis Hubler, Mark Murphy, Dorte Renneberg, Simon Stamm
  • 2,4,6,7-TETRAHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-5-ONE DERIVATIVES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS FOR TREATING VASCULITIS AND INFLAMMATORY DISEASES
    Publication number: 20230192708
    Abstract: The present invention relates to derivatives of formula (I) wherein Ring A, X, Y, Z, RA, R1, R2, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.
    Type: Application
    Filed: December 20, 2022
    Publication date: June 22, 2023
    Inventors: Sylvie FROIDEVAUX, Francis HUBLER, Mark MURPHY, Dorte RENNEBERG, Simon STAMM
  • AZETIDIN-3-YLMETHANOL DERIVATIVES AS CCR6 RECEPTOR MODULATORS
    Publication number: 20230174514
    Abstract: The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the treatment or prevention of various diseases, conditions or disorders.
    Type: Application
    Filed: April 30, 2021
    Publication date: June 8, 2023
    Inventors: Oliver ALLEMANN, Eva CAROFF, Alexia CHAVANTON-ARPEL, Andrew CROXFORD, Francis HUBLER, Loïc JACOB, Emmanuel MEYER, Sylvia RICHARD-BILDSTEIN
  • Substituted tetrahydropyrazolo[3,4-d]pyrimidines and tetrahydropyrazolo[4,3-d]pyrimidines as C5A receptor modulators
    Patent number: 11608341
    Abstract: The present invention relates to derivatives of formula (I) wherein Ring A, X, Y, Z, RA, R1, R2, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: March 21, 2023
    Assignee: Idorsia Pharmaceuticals Ltd.
    Inventors: Sylvie Froidevaux, Francis Hubler, Mark Murphy, Dorte Renneberg, Simon Stamm
  • PHARMACEUTICAL COMPOSITION COMPRISING A TETRAHYDROPYRAZOLOPYRIMIDINONE COMPOUND
    Publication number: 20220265658
    Abstract: The invention relates to pharmaceutical compositions, which are self-emulsifying, self-microemulsifying, or self-nanoemulsifying in aqueous medium, comprising the compound: 2-(2,2-Difluoro-propyl)-5-[1-(2-fluoro-6-methyl-phenyl)-piperidin-4-yl]-7-(2-trifluoromethyl-benzyl)-2,4,5,7-tetrahydro-pyrazolo[3,4-d]pyrimidin-6-one and a mixture of excipients comprising one or more lipophilic excipient(s); one or more hydrophilic surfactant(s); and optionally one or more hydrophilic co-solvent(s). The invention further relates to a crystalline form of said compound, and its use for the preparation of the present compositions. The invention further relates to pharmaceutical uses of the compositions for the prevention/prophylaxis or treatment of diseases and disorders related to pathogenic events associated with elevated levels of C5a and/or with C5aR activation.
    Type: Application
    Filed: July 8, 2020
    Publication date: August 25, 2022
    Inventors: Michael AMBUEHL, Elvire FOURNIER, Amandine FRAICHARD, Sylvie FROIDEVAUX, Oliver GEISELER, Charlyse HERRMANN, Francis HUBLER, Mark MURPHY, Dorte RENNEBERG, Simon STAMM, Markus VON RAUMER
  • C5A RECEPTOR MODULATORS
    Publication number: 20210122736
    Abstract: The present invention relates to derivatives of formula (I) wherein Ring A, W, X, Y, Z, R1, R2, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.
    Type: Application
    Filed: January 18, 2019
    Publication date: April 29, 2021
    Inventors: Sylvie FROIDEVAUX, Francis HUBLER, Mark MURPHY, Dorte RENNEBERG, Simon STAMM
  • 2,4,6,7-TETRAHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-5-ONE DERIVATIVES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS FOR TREATING VASCULITIS AND INFLAMMATORY DISEASES
    Publication number: 20200369672
    Abstract: The present invention relates to derivatives of formula (I) wherein Ring A, X, Y, Z, RA, R1, R2, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.
    Type: Application
    Filed: January 9, 2019
    Publication date: November 26, 2020
    Applicant: Idorsia Pharmaceuticals Ltd.
    Inventors: Sylvie FROIDEVAUX, Francis HUBLER, Mark MURPHY, Dorte RENNEBERG, Simon STAMM
  • C5A RECEPTOR MODULATORS
    Publication number: 20200347029
    Abstract: The present invention relates to derivatives of formula (I) wherein ring A, X, Y, Z, R1, R2, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.
    Type: Application
    Filed: January 18, 2019
    Publication date: November 5, 2020
    Inventors: Sylvie FROIDEVAUX, Francis HUBLER, Mark MURPHY, Dorte RENNEBERG, Simon STAMM
  • Indole carboxamide derivatives as P2X7 receptor antagonist
    Patent number: 9718774
    Abstract: The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: August 1, 2017
    Assignee: IDORSIA PHARMACEUTICALS LTD
    Inventors: Kurt Hilpert, Francis Hubler, Thierry Kimmerlin, Dorte Renneberg, Simon Stamm
  • Indole carboxamide derivatives as P2Xreceptor antagonists
    Patent number: 9556117
    Abstract: The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: January 31, 2017
    Assignee: ACTELION PHARMACEUTICALS LTD.
    Inventors: Kurt Hilpert, Francis Hubler, Dorte Renneberg, Simon Stamm
  • Heterocyclic amide derivatives as P2X7 receptor antagonists
    Patent number: 9409917
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, X and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: August 9, 2016
    Assignee: ACTELION PHARMACEUTICALS LTD.
    Inventors: Kurt Hilpert, Francis Hubler, Thierry Kimmerlin, Dorte Renneberg, Simon Stamm
  • Heterocyclic amide derivatives as P2X7 receptor antagonists
    Patent number: 9388197
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, n, m, p and X are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: July 12, 2016
    Assignee: ACTELION PHARMACEUTICALS LTD.
    Inventors: Kurt Hilpert, Francis Hubler, Dorte Renneberg, Simon Stamm
  • Heterocyclic amide derivatives as P2Xreceptor antagonists
    Patent number: 9388198
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, n and X are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: July 12, 2016
    Assignee: ACTELION PHARMACEUTICALS LTD.
    Inventors: Kurt Hilpert, Francis Hubler, Dorte Renneberg, Simon Stamm
  • Heterocyclic amide derivatives as P2X7 receptor antagonists
    Patent number: 9221832
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, X, Y and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: December 29, 2015
    Assignee: ACTELION PHARMACEUTICALS LTD.
    Inventors: Kurt Hilpert, Francis Hubler, Thierry Kimmerlin, Dorte Renneberg, Simon Stamm, Mark Murphy
  • HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
    Publication number: 20150361096
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, n, m, p and X are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Application
    Filed: January 21, 2014
    Publication date: December 17, 2015
    Inventors: KURT HILPERT, FRANCIS HUBLER, DORTE RENNEBERG, SIMON STAMM
  • HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
    Publication number: 20150361097
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, n and X are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Application
    Filed: January 21, 2014
    Publication date: December 17, 2015
    Inventors: KURT HILPERT, FRANCIS HUBLER, DORTE RENNEBERG, SIMON STAMM
  • INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
    Publication number: 20150344425
    Abstract: The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Application
    Filed: December 17, 2013
    Publication date: December 3, 2015
    Applicant: ACTELION PHARMACEUTICALS LTD
    Inventors: KURT HILPERT, FRANCIS HUBLER, DORTE RENNEBERG, SIMON STAMM
  • INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONIST
    Publication number: 20150322008
    Abstract: The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Application
    Filed: December 11, 2013
    Publication date: November 12, 2015
    Applicant: ACTELION PHARMACEUTICALS LTD
    Inventors: KURT HILPERT, FRANCIS HUBLER, THIERRY KIMMERLIN, DORTE RENNEBERG, SIMON STAMM
  • HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
    Publication number: 20150025075
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, X and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Application
    Filed: January 18, 2013
    Publication date: January 22, 2015
    Applicant: ACTELION PHARMACEUTICALS LTD.
    Inventors: Kurt Hilpert, Francis Hubler, Thierry Kimmerlin, Dorte Renneberg, Simon Stamm