Patents by Inventor Francis Ignatious

Francis Ignatious has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TOPICAL FORMULATIONS OF A JAK 1/3 INHIBITOR AND METHODS OF USE THEREOF FOR TREATMENT OF ATOPIC DERMATITIS AND OTHER SKIN CONDITIONS
    Publication number: 20240139170
    Abstract: The present disclosure relates methods for treating skin disorders caused by an immune deficiency with topical formulations comprising ethyl (R)-4-((1-(2-cyanoacetyl)piperidin-3-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (Compound I) or pharmaceutically acceptable derivative thereof. In particular, the topical formulations described herein may be used to treat atopic dermatitis, alopecia areata, or vitiligo.
    Type: Application
    Filed: February 18, 2022
    Publication date: May 2, 2024
    Inventors: Paul CHANGELIAN, David GORDON, Francis IGNATIOUS, Walter SMITH, Steve TUCKER, Neal Stuart WALKER
  • Polymeric micellar complexes and drug delivery vehicles thereof
    Publication number: 20070086975
    Abstract: Disclosed are complexes of an amphiphilic copolymer, wherein the amphiphilic copolymer has benzoyl sulfonic acid groups on the hydrophobic segment of the copolymer.
    Type: Application
    Filed: December 17, 2004
    Publication date: April 19, 2007
    Inventors: Francis Ignatious, Yu Li
  • Heterofunctional copolymers of glycerol and polyethylene glycol, their conjugates and compositions
    Patent number: 7196145
    Abstract: The present invention relates to heterofunctional copolymers of glycerol and polyethylene glycol, conjugates of these heterofunctional copolymers with bioactive agents, nanoparticles, hydrophobic polymers and/or lipids; and to compositions containing these conjugates.
    Type: Grant
    Filed: August 25, 2004
    Date of Patent: March 27, 2007
    Assignee: SmithKline Beecham Corporation
    Inventor: Francis Ignatious
  • Encapsulation of water soluble peptides
    Publication number: 20070009605
    Abstract: This invention relates to a process for preparing biodegradable microspheres and or nanospheres using an oil-in-water process for the controlled release of bioactive peptides.
    Type: Application
    Filed: June 5, 2006
    Publication date: January 11, 2007
    Inventor: Francis Ignatious
  • Stabilized topotecan liposomal composition and methods
    Publication number: 20060222694
    Abstract: A topotecan liposomal composition which can be reconstituted from a lyophilized form to an injectable liposome suspension having selected liposome sizes in the size range between 0.05 and 0.25 microns, and between about 85-100% liposome-entrapped topotecan is disclosed.
    Type: Application
    Filed: June 25, 2004
    Publication date: October 5, 2006
    Inventors: Choon Oh, Francis Ignatious
  • Sustained release ionic conjugate
    Publication number: 20060121120
    Abstract: A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing biodegradable polymer and a free amino group-containing drug which are ionically bonded to each other.
    Type: Application
    Filed: January 19, 2006
    Publication date: June 8, 2006
    Inventors: Francis Ignatious, Thomas Loughman, Shalaby Shalaby, Franck Touraud
  • Amorphous pharmaceutical compositions
    Publication number: 20060083784
    Abstract: The present invention is directed to use of electrospinning, i.e. the process of making polymer nanofibers from either a solution or melt under electrical forces, to prepare stable, solid dispersions of amorphous drugs in polymer nanofibers. The present invention is also directed to the process of making solid dispersions of amorphous forms and compositions of rosiglitazone and its pharmaceutically acceptable salts.
    Type: Application
    Filed: February 24, 2005
    Publication date: April 20, 2006
    Inventors: Francis Ignatious, Linghong Sun, Andrew Craig, David Crowe, Tim Ho, Michael Millan
  • Electrospun amorphous pharmaceutical compositions
    Publication number: 20060013869
    Abstract: The present invention is directed to use of electrospinning, i.e. the process of making polymer nanofibers from either a solution or melt under electrical forces, to prepare stable, solid dispersions of amorphous drugs in polymer nanofibers.
    Type: Application
    Filed: August 7, 2003
    Publication date: January 19, 2006
    Inventors: Francis Ignatious, Linghong Sun
  • Lactone bearing absorbable polymers
    Publication number: 20050267280
    Abstract: The present invention pertains to biodegradable polymers comprising a non-polymerizable lactone, biodegradable compositions comprising the polymer and a therapeutic agent, the use of the compositions for the sustained release of therapeutic agents, wherein the therapeutic agent is reversibly immobilized on the polymer matrix using ionic complexation between the latent carboxylic groups present on the lactone bearing polymer matrix and a cationic group on the therapeutic agent.
    Type: Application
    Filed: April 26, 2005
    Publication date: December 1, 2005
    Inventor: Francis Ignatious
  • Sustained release ionic conjugate
    Publication number: 20050074492
    Abstract: A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing biodegradable polymer and a free amino group-containing drug which are ionically bonded to each other.
    Type: Application
    Filed: August 7, 2003
    Publication date: April 7, 2005
    Inventors: Francis Ignatious, Thomas Loughman, Shalaby Shalaby, Franck Touraud
  • Heterofunctional copolymers of glycerol and polyethylene glycol, their conjugates and compositions
    Publication number: 20050048650
    Abstract: The present invention relates to heterofunctional copolymers of glycerol and polyethylene glycol, conjugates of these heterofunctional copolymers with bioactive agents, nanoparticles, hydrophobic polymers and/or lipids; and to compositions containing these conjugates.
    Type: Application
    Filed: August 25, 2004
    Publication date: March 3, 2005
    Inventor: Francis Ignatious
  • Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
    Publication number: 20050009741
    Abstract: A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
    Type: Application
    Filed: July 27, 2004
    Publication date: January 13, 2005
    Inventors: Shalaby Shalaby, Ruth Russell, Jacques-Pierre Moreau, Steven Jackson, Francis Ignatious
  • Products and drug delivery vehicles
    Publication number: 20040208844
    Abstract: Disclosed are products useful as, or in, drug delivry vehicles.
    Type: Application
    Filed: January 28, 2004
    Publication date: October 21, 2004
    Inventor: Francis Ignatious
  • Electrospun pharmaceutical compositions
    Publication number: 20030017208
    Abstract: The present invention is directed to an electrospun pharmaceutical composition comprising a pharmaceutically acceptable actibe agent, and a pharmaceutically acceptable polymeric carrier for use in therapy.
    Type: Application
    Filed: July 19, 2002
    Publication date: January 23, 2003
    Inventors: Francis Ignatious, John M. Baldoni
  • Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
    Patent number: 5821221
    Abstract: A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
    Type: Grant
    Filed: September 9, 1997
    Date of Patent: October 13, 1998
    Assignee: Biomeasure, Incorporated
    Inventors: Shalaby W. Shalaby, Steven A. Jackson, Francis Ignatious, Jacques-Pierre Moreau
  • Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
    Patent number: 5665702
    Abstract: A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 9, 1997
    Assignee: Biomeasure Incorporated
    Inventors: Shalaby W. Shalaby, Steven A. Jackson, Francis Ignatious, Jacques-Pierre Moreau