Patents by Inventor Francis J. Burrows

Francis J. Burrows has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assays and Implements for Determining and Modulating HSP90 Binding Activity
    Publication number: 20080318338
    Abstract: Ligand binding assays as applied to HSP90s as receptors or ligands, and reagents useful therefore, are described and claimed, as are methods of assaying for HSP90 modulators and methods of using the resulting products identified thereby.
    Type: Application
    Filed: April 15, 2008
    Publication date: December 25, 2008
    Inventors: Adeela Kamal, Francis J. Burrows, Lin Zhang, Marcus F. Boehm
  • Ansamycins having improved pharmacological and biological properties
    Patent number: 7465718
    Abstract: Ansamycins and methods of preparing and using the same are described. At least some of these ansamycins exhibit one or more of improved aqueous formulation ability, chemical stability, and bioavailability. Some of the derivatives described are dimers. These and others described can include one or more solubilizing groups that have expected merit in rendering the overall compounds useful as drugs and prodrugs.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: December 16, 2008
    Assignee: Conforma Therapeutics Corporation
    Inventors: Lin Zhang, Jean-Yves Le Brazidec, Lawrence C. Fritz, Francis J. Burrows, Marcus F. Boehm, Junhua Fan, Sean Konrad McHugh
  • Methods and Compositions for Treating Chronic Lymphocytic Leukemia
    Publication number: 20080280878
    Abstract: Novel method of treating chronic lymphocytic leukemia by the administering of HSP90 inhibitors, particularly ansamycins, more particularly I 7-allylamino-I 7-demethoxygetdanarnycin (17-AAG).
    Type: Application
    Filed: November 2, 2005
    Publication date: November 13, 2008
    Inventors: Januario E. Castro, Thomas J. Kipps, Francis J. Burrows, Adeela Kamal, Carlos E. Prada
  • Combined methods for tumor vasculature targeting and tumor treatment with radiotherapy
    Patent number: 7125541
    Abstract: The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
    Type: Grant
    Filed: December 14, 2000
    Date of Patent: October 24, 2006
    Assignee: The University of Texas System Board of Regents
    Inventors: Philip E. Thorpe, Francis J. Burrows
  • Combined methods and compositions for tumor vasculature targeting and tumor treatment
    Patent number: 7112317
    Abstract: The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: September 26, 2006
    Assignee: Board of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Francis J. Burrows
  • Combined methods and compositions for tumor vasculature targeting and tumor treatment
    Publication number: 20030185832
    Abstract: The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
    Type: Application
    Filed: February 27, 2003
    Publication date: October 2, 2003
    Applicant: Board of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Francis J. Burrows
  • Combined methods and compositions for tumor vasculature targeting and tumor treatment
    Publication number: 20020037289
    Abstract: The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
    Type: Application
    Filed: December 14, 2000
    Publication date: March 28, 2002
    Applicant: Board of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Francis J. Burrows
  • Diagnostic methods for targeting the vasculature of solid tumors
    Patent number: 6261535
    Abstract: The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
    Type: Grant
    Filed: December 8, 1998
    Date of Patent: July 17, 2001
    Assignee: The University of Texas System Board of Regents
    Inventors: Philip E. Thorpe, Francis J. Burrows
  • Compositions for targeting the vasculature of solid tumors
    Patent number: 6051230
    Abstract: The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: April 18, 2000
    Assignee: Board of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Francis J. Burrows
  • Methods for targeting the vasculature of solid tumors
    Patent number: 6004554
    Abstract: The present invention relates generally to methods and compositions for targeting the vasulature of solid tumors using immunologcially-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: December 21, 1999
    Assignee: Board of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Francis J. Burrows
  • Methods and compositions for targeting the vasculature of solid tumors
    Patent number: 5965132
    Abstract: The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: October 12, 1999
    Assignee: Board of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Francis J. Burrows
  • Compositions for targeting the vasculature of solid tumors
    Patent number: 5863538
    Abstract: The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: January 26, 1999
    Assignee: Board of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Francis J. Burrows
  • Methods for treating the vasculature of solid tumors
    Patent number: 5855866
    Abstract: The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunologically-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
    Type: Grant
    Filed: March 2, 1994
    Date of Patent: January 5, 1999
    Assignee: Board of Regenis, The University of Texas System
    Inventors: Philip E. Thorpe, Francis J. Burrows
  • Methods for targeting the vasculature of solid tumors
    Patent number: 5776427
    Abstract: The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: July 7, 1998
    Assignee: Board of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Francis J. Burrows
  • Antibodies that bind to endoglin
    Patent number: 5660827
    Abstract: Disclosed are antibodies that specifically bind to endoglin. Conjugates of the antibodies linked to diagnostic or therapeutic agents are also provided. Methods of using the antibodies and conjugates are also disclosed, including methods of targeting the vasculature of solid tumors through recognition of the tumor vasculature-associated antigen, endoglin.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: August 26, 1997
    Assignee: Board of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Francis J. Burrows