Patents by Inventor Francis J. Doyle
Francis J. Doyle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9907515Abstract: A machine for processing continuous glucose monitoring data and issuing an alert if hypoglycemia is imminent has three modules: (a) a pre-processing module that receives and modulates continuous glucose monitoring data by reducing noise and adjusting for missed data points and shifts due to calibration; (b) a core algorithm module that receives data from the pre-processing module and calculates a rate of change to make a hypoglycemia prediction, and determine if hypoglycemia is imminent; and (c) an alarm mode module that receives data from the core algorithm and issues an audio or visual alert or warning message or a negative feedback signal to an insulin delivery device if hypoglycemia is imminent.Type: GrantFiled: February 2, 2017Date of Patent: March 6, 2018Assignee: The Regents of the University of CaliforniaInventors: Francis J. Doyle, III, Eyal Dassau, Howard Zissser, Rebecca Harvey
-
Patent number: 9719085Abstract: Disclosed are RNA constructs which function to activate or inactivate a biological process, e.g., may be designed for attachment to a polypeptide coding region. Such RNA constructs modulate translation of a polypeptide from the coding region in response to the presence of a target polynucleotide in an expression environment. Such RNA constructs include a weakened stem-loop structure which, when bound to the target polynucleotide, assumes stem-loop secondary structure and associates with an RNA binding protein. Association with the RNA binding protein modulates translation of the polypeptide coding region. Such RNA constructs also have three-way junction joining regions 3? and 5? of the stem-loop structure.Type: GrantFiled: August 20, 2014Date of Patent: August 1, 2017Assignee: The Research Foundation of the University of New YorkInventors: Scott A. Tenenbaum, Francis J. Doyle, II, Ajish George, Christopher Zaleski
-
Patent number: 9700708Abstract: The disclosure relates to drug delivery and maintaining multiple defined physiological zones using model predictive control.Type: GrantFiled: April 2, 2013Date of Patent: July 11, 2017Assignee: The Regents of the University of CaliforniaInventors: Francis J. Doyle, III, Benyamin Grosman, Eyal Dassau, Lois Jovanovic, Howard Zisser
-
Publication number: 20170156682Abstract: A machine for processing continuous glucose monitoring data and issuing an alert if hypoglycemia is imminent has three modules: (a) a pre-processing module that receives and modulates continuous glucose monitoring data by reducing noise and adjusting for missed data points and shifts due to calibration; (b) a core algorithm module that receives data from the pre-processing module and calculates a rate of change to make a hypoglycemia prediction, and determine if hypoglycemia is imminent; and (c) an alarm mode module that receives data from the core algorithm and issues an audio or visual alert or warning message or a negative feedback signal to an insulin delivery device if hypoglycemia is imminent.Type: ApplicationFiled: February 2, 2017Publication date: June 8, 2017Applicant: The Regents of the University of CaliforniaInventors: Francis J. Doyle, III, Eyal Dassau, Howard Zissser, Rebecca Harvey
-
Publication number: 20170143899Abstract: Methods, devices, algorithms, and systems controlling insulin delivery employ velocity-weighting. Predicted glucose outcomes are penalized with a cost modulated by a factor that is a function of the glucose velocity, wherein glucose outcomes are penalized increasingly less for increasingly negative glucose velocities, when glucose level is high, and/or wherein a hyperglycemic glucose value that is already converging to the euglycemic zone results in less corrective action by the controller than were the hyperglycemic state steady.Type: ApplicationFiled: June 29, 2016Publication date: May 25, 2017Applicant: The Regents of the University of CaliforniaInventors: Ravi L. Gondhalekar, Eyal Dassau, Francis J. Doyle, III
-
Publication number: 20170147781Abstract: A state-estimator for the estimation or initialization of the state of a discrete-time state-space dynamical model based on sensor measurements of the model output, comprising fitting a continuous-time function to acquired sensor measurement data-points of each model output, and subsequently sampling the continuous time function at exactly the sample-period of the state-space dynamic model for which the state is being estimated or initialized, in order to construct a model state via a synthesized output trajectory.Type: ApplicationFiled: February 4, 2017Publication date: May 25, 2017Applicant: The Regents of the University of CaliforniaInventors: Ravi L. Gondhalekar, Francis J. Doyle, III, Eyal Dassau
-
Publication number: 20160369271Abstract: Disclosed are RNA constructs which function to bind and/or inhibit a non-coding RNA (e.g., a miRNA). Such RNA constructs include an optionally weakened stem-loop structure stabilized by binding to a non-coding RNA. The non-coding RNA preferentially binds to the RNA construct as compared to a natural target (e.g., a mRNA). In certain embodiments, the RNA construct inhibits the function of the non-coding RNA. Such RNA constructs also have three-way junction joining regions 3? and 5? of the stem-loop structure.Type: ApplicationFiled: September 17, 2014Publication date: December 22, 2016Inventors: Francis J. Doyle, II, Zachary E. Wurz, Scott Tenenbaum, Edward Eveleth
-
Publication number: 20160256087Abstract: A glucose rate increase detector (GRID) for use in an artificial pancreas (AP), wherein the GRID detects in a person persistent increases in glucose associated with a meal, and either triggers a meal bolus to blunt meal peak safely, during closed-loop control, or alerts the person to bolus for a meal, during open-loop control.Type: ApplicationFiled: May 7, 2016Publication date: September 8, 2016Applicant: The Regents of the University of CaliforniaInventors: Francis J. Doyle, III, Rebecca Harvey, Eyal Dassau, Howard Zisser
-
Publication number: 20160015890Abstract: Disclosed are systems and methods for variable dose glucagon delivery without the need to manually reconstitute the glucagon. These systems and methods mat be utilized with or without a separate continuous glucose monitor. The variability of the dose may be determined manually by the user, caregiver or responder, or by preprogrammed algorithms utilizing the input from an external sensor such as a continuous glucose monitor.Type: ApplicationFiled: June 9, 2015Publication date: January 21, 2016Inventors: Eyal Dassau, Howard Craig Zisser, Samir Suresh Mitragotri, Francis J. Doyle, III
-
Patent number: 9227014Abstract: Techniques for controlling an insulin pump include determining values for parameters selected from a group including a first prediction time horizon, a predicted glucose threshold (Goff) for turning the insulin pump off, a maximum shut off time within a time window, and duration of the time window. A safety rule is determined based on the maximum shut off time within the duration. Glucose readings are collected up to a current time. An expected current glucose value G and glucose temporal rate of change are determined based only on the glucose readings and a Kalman filter configured for noisy glucose readings. A glucose level (Gh1) is predicted for a future time that is the prediction time horizon after the current time. A command is issued to shut off the insulin pump if it is determined both that Gh1 is less than Goff and that the safety rule is satisfied.Type: GrantFiled: February 7, 2014Date of Patent: January 5, 2016Assignees: The Board of Trustees of the Laland Stanford Junior University, The Regents of the University of California, a California Corporation, The Regents of the University of Colorado, a body corporate, Rensselaer Polytechnic InstituteInventors: Bruce A. Buckingham, B. Wayne Bequette, Fraser Cameron, Darrell M. Wilson, H. Peter Chase, Francis J. Doyle, III, Matthew Stenerson
-
Publication number: 20150306314Abstract: A model-based control scheme consisting of either a proportional-integral-derivative (IMC-PID) controller or a model predictive controller (MPC), with an insulin feedback (IFB) scheme personalized based on a priori subject characteristics and comprising a lower order control-relevant model to obtain PID or MPC controller for artificial pancreas (AP) applications.Type: ApplicationFiled: July 6, 2015Publication date: October 29, 2015Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Francis J. Doyle, III, Eyal Dassau, Dale E. Seborg, Joon Bok Lee
-
Publication number: 20150045414Abstract: Disclosed are RNA constructs which function to activate or inactivate a biological process, e.g., may be designed for attachment to a polypeptide coding region. Such RNA constructs modulate translation of a polypeptide from the coding region in response to the presence of a target polynucleotide in an expression environment. Such RNA constructs include a weakened stem-loop structure which, when bound to the target polynucleotide, assumes stem-loop secondary structure and associates with an RNA binding protein. Association with the RNA binding protein modulates translation of the polypeptide coding region. Such RNA constructs also have three-way junction joining regions 3? and 5? of the stem-loop structure.Type: ApplicationFiled: August 20, 2014Publication date: February 12, 2015Inventors: Scott A. Tenenbaum, Francis J. Doyle, II, Ajish George, Christopher Zaleski
-
Patent number: 8841438Abstract: Disclosed are RNA constructs which function to activate or inactivate a biological process, e.g., may be designed for attachment to a polypeptide coding region. Such RNA constructs modulate translation of a polypeptide from the coding region in response to the presence of a target polynucleotide in an expression environment. Such RNA constructs include a weakened stem-loop structure which, when bound to the target polynucleotide, assumes stem-loop secondary structure and associates with an RNA binding protein. Association with the RNA binding protein modulates translation of the polypeptide coding region. Such RNA constructs also have three-way junction joining regions 3? and 5? of the stem-loop structure.Type: GrantFiled: May 21, 2010Date of Patent: September 23, 2014Assignee: The Research Foundation of the University of New YorkInventors: Scott A. Tenenbaum, Francis J. Doyle, II, Ajish George, Christopher Zaleski
-
Publication number: 20140221966Abstract: Techniques for controlling an insulin pump include determining values for parameters selected from a group including a first prediction time horizon, a predicted glucose threshold (Goff) for turning the insulin pump off, a maximum shut off time within a time window, and duration of the time window. A safety rule is determined based on the maximum shut off time within the duration. Glucose readings are collected up to a current time. An expected current glucose value G and glucose temporal rate of change are determined based only on the glucose readings and a Kalman filter configured for noisy glucose readings. A glucose level (Gh1) is predicted for a future time that is the prediction time horizon after the current time. A command is issued to shut off the insulin pump if it is determined both that Gh1 is less than Goff and that the safety rule is satisfied.Type: ApplicationFiled: February 7, 2014Publication date: August 7, 2014Applicants: The Board of Trustees of the Leland Stanford Junior University, Rensselaer Polytechnic Institute, The Regents of the University of Colorado, a body corporate, The Regents of the University of California, a California CorporationInventors: Bruce A. Buckingham, B. Wayne Bequette, Fraser Cameron, Darrell M. Wilson, H. Peter Chase, Francis J. Doyle, III, Matthew Stenerson
-
Publication number: 20140200559Abstract: A controller for an artificial pancreas for automated insulin delivery to patients with type 1 diabetes mellitus (T1DM) that enforces safe insulin delivery throughout both day and night, wherein the controller employs zone model predictive control, whereby real-time optimization, based on a model of a human's insulin response, is utilized to regulate blood glucose levels to a safe zone, and time-dependent zones that smoothly modulate the controller correction based on the time of day, wherein the controller strategically strives to maintain an 80-140 mg/dL glucose zone during the day, a 110-220 mg/dL zone at night, and a smooth transition of 2 hour duration in between.Type: ApplicationFiled: January 14, 2014Publication date: July 17, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Francis J. Doyle, III, Eyal Dassau, Ravi L. Gondhalekar
-
Patent number: 8762070Abstract: A method, computer implemented method and associated apparatus for the management of diabetes comprises utilizing zone model predictive control (Zone-MPC) to control delivery of an insulin or insulin analog within a zone of desired values.Type: GrantFiled: February 11, 2011Date of Patent: June 24, 2014Assignees: Regents of the University of California, Sansum Diabetes Research InstituteInventors: Francis J. Doyle, III, Benyamin Grosman, Eyal Dassau, Lois Javanovic, Howard Zisser
-
Publication number: 20130231642Abstract: The disclosure relates to drug delivery and maintaining multiple defined physiological zones using model predictive control.Type: ApplicationFiled: April 2, 2013Publication date: September 5, 2013Inventors: Francis J. Doyle, III, Benyamin Grosman, Eyal Dassau, Lois Jovanovic, Howard Zisser
-
Publication number: 20120252876Abstract: Disclosed are RNA constructs which function to activate or inactivate a biological process, e.g., may be designed for attachment to a polypeptide coding region. Such RNA constructs modulate translation of a polypeptide from the coding region in response to the presence of a target polynucleotide in an expression environment. Such RNA constructs include a weakened stem-loop structure which, when bound to the target polynucleotide, assumes stem-loop secondary structure and associates with an RNA binding protein. Association with the RNA binding protein modulates translation of the polypeptide coding region. Such RNA constructs also have three-way junction joining regions 3? and 5? of the stem-loop structure.Type: ApplicationFiled: May 21, 2010Publication date: October 4, 2012Inventors: Scott A. Tenenbaum, Francis J. Doyle, II, Ajish George, Christopher Zaleski
-
Publication number: 20110313680Abstract: A machine for processing continuous glucose monitoring data and issuing an alert if hypoglycemia is imminent has three modules: (a) a pre-processing module that receives and modulates continuous glucose monitoring data by reducing noise and adjusting for missed data points and shifts due to calibration; (b) a core algorithm module that receives data from the pre-processing module and calculates a rate of change to make a hypoglycemia prediction, and determine if hypoglycemia is imminent; and (c) an alarm mode module that receives data from the core algorithm and issues an audio or visual alert or warning message or a negative feedback signal to an insulin delivery device if hypoglycemia is imminent.Type: ApplicationFiled: June 22, 2011Publication date: December 22, 2011Inventors: Francis J. Doyle, III, Eyal Dassau, Howard Zisser, Rebecca A. Harvey
-
Publication number: 20110208156Abstract: A method, computer implemented method and associated apparatus for the management of diabetes is provided.Type: ApplicationFiled: February 11, 2011Publication date: August 25, 2011Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SANSUM DIABETES RESEARCH INSTITUTEInventors: Francis J. Doyle, III, Benyamin Grosman, Eyal Dassau, Lois Javanovic, Howard Zisser