Patents by Inventor Francis J. Lenoch

Francis J. Lenoch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for reverse transcriptase activity measurement using fluorescence polarization
    Patent number: 6100039
    Abstract: Described is a process for detecting reverse transcriptase activity and, thereby, reverse transcriptase inhibitors using fluorescence polarization, comprising, mixing a DNA primer with an RNA template. Then forming an RNA/DNA duplex utilizing the reverse transcriptase and removing the RNA from the RNA/DNA duplex to form single-stranded DNA. Finally, adding a fluorescent-labeled oligonucleotide complementary to the single-stranded DNA for hybridizing to the single-stranded DNA; and, measuring the fluorescence polarization.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: August 8, 2000
    Assignee: Panvera, Inc.
    Inventors: Thomas J. Burke, Randall E. Bolger, Francis J. Lenoch
  • Method for detecting and quantitating nucleic acid impurities in biochemical preparations
    Patent number: 5824557
    Abstract: A homogeneous fluorescence-based nucleic acid detection and quantitation system is provided to measure nucleic acid in protein solutions. The process relies on the intercalation of a non-fluorescent dye into a double-stranded nucleic acid helix or single-stranded nucleic acid. The dye fluoresces after intercalation and the intensity is a direct measurement of the amount of nucleic acid present in the sample.
    Type: Grant
    Filed: April 2, 1996
    Date of Patent: October 20, 1998
    Assignee: PanVera Corporation
    Inventors: Thomas J. Burke, Randall E. Bolger, Francis J. Lenoch