Patents by Inventor Francis J. Tinney

Francis J. Tinney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted tetra- and pentapeptide inhibitors of protein: farnesyl transferase
    Patent number: 5763577
    Abstract: Inhibitors of protein:farnesyl transferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: June 9, 1998
    Assignee: Warner-Lambert Company
    Inventors: Gary Louis Bolton, Alfred Campbell, Richard Gowan, John Cooke Hodges, Donald Hupe, Daniele Leonard, Tomi Sawyer, Judith Sebolt-Leopold, Francis J. Tinney
  • Renin inhibitors IV
    Patent number: 5024994
    Abstract: The invention concerns novel renin-inhibitory peptides which are useful for treating renin-assocated hypertension, hyperaldosteronism, and congestive heart failure. Processes for preparing the peptides, compositions containing them and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension or hyperaldosteronism.
    Type: Grant
    Filed: August 17, 1988
    Date of Patent: June 18, 1991
    Assignee: Warner-Lambert Company
    Inventors: Annette M. Doherty, James P. Hudspeth, James S. Kaltenbronn, Joseph T. Repine, William H. Roark, Ila Sircar, Francis J. Tinney
  • Renin inhibitors
    Patent number: 4743585
    Abstract: The invention concerns novel renin-inhibitory peptides which are useful for treating renin associated hypertension and for treating hyperaldosteronism. Novel intermediates, processes for preparing both the intermediates and the novel peptides, pharmaceutical compositions, and methods of treatment are included.
    Type: Grant
    Filed: November 21, 1986
    Date of Patent: May 10, 1988
    Assignee: Warner-Lambert Company
    Inventors: James P. Hudspeth, James S. Kaltenbronn, Elizabeth A. Lunney, Joseph T. Repine, W. Howard Roark, Michael A. Stier, Francis J. Tinney, Peter W. K. Woo, Ernest D. Nicolaides
  • Modified tripeptides
    Patent number: 4596819
    Abstract: Modified oxytocin-vasopressin di- or tri-peptides wherein an amide group is replaced by a group selected from ##STR1## --CH.sub.2 NH--, --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, --CH.sub.2 SO.sub.2 --, --CH.sub.2 CH.sub.2 -- and --CH.dbd.CH-- are described as well as methods for their manufacture, pharmaceutical compositions and methods for treatment, especially of cognitive disorders, depression, morphine dependency and parkinsonism by adjunctive therapy.
    Type: Grant
    Filed: January 23, 1984
    Date of Patent: June 24, 1986
    Assignee: Warner-Lambert Company
    Inventors: Ernest D. Nicolaides, Francis J. Tinney, James S. Kaltenbronn, Dana E. DeJohn, Elizabeth A. Lunney, W. Howard Roark, Joseph T. Repine
  • Certain 2-pyridylamino-3-thiophene carboxylic acid derivatives
    Patent number: 4332947
    Abstract: Oxo-pyrido[1,2-a]thienopyrimidine compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds and methods for treating allergies using said compositions are disclosed.
    Type: Grant
    Filed: January 30, 1981
    Date of Patent: June 1, 1982
    Assignee: Warner-Lambert Company
    Inventors: Francis J. Tinney, David T. Connor, Wiaczeslaw A. Cetenko, Joseph J. Kerbleski, Roderick J. Sorenson
  • Dihydro-oxo-pyrido[1,2-a]thienopyrimidine compounds
    Patent number: 4287340
    Abstract: Oxo-pyrido[1,2-a]thienopyrimidine compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds and methods for treating allergies using said compositions are disclosed.
    Type: Grant
    Filed: March 21, 1980
    Date of Patent: September 1, 1981
    Assignee: Warner-Lambert Company
    Inventors: Francis J. Tinney, David T. Connor, Wiaczeslaw A. Cetenko, Joseph J. Kerbleski, Roderick J. Sorenson
  • Oxo-pyrido[1,2-a]thienopyrimidine compounds and methods for their production
    Patent number: 4230707
    Abstract: Oxo-pyrido[1,2-a]thienopyrimidine compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds and methods for treating allergies using said compositions are disclosed.
    Type: Grant
    Filed: August 27, 1979
    Date of Patent: October 28, 1980
    Assignee: Warner-Lambert Company
    Inventors: Francis J. Tinney, David T. Connor, Wiaczeslaw A. Cetenko, Joseph J. Kerbleski, Roderick J. Sorenson
  • Pyroglutamyl-histidyl-tryptophanyl-seryl-tyrosyl hydrazides
    Patent number: 4128540
    Abstract: A new decapeptide having the formula, pGlu-His-Trp-Ser-Tyr-Gly-Leu-NO.sub.2 Arg-Pro-Gly(NH.sub.2); salts thereof; production thereof by reacting pGlu-His-Trp-Ser-Tyr(N.sub.3) with Gly-Leu-NO.sub.2 Arg-Pro-Gly(NH.sub.2), by reacting pGlu-His-Trp-Ser-Tyr-Gly(N.sub.3) with Leu-NO.sub.2 Arg-Pro-Gly(NH.sub.2), or by reacting pGlu-His-Trp-Ser-Tyr-Gly-Leu(N.sub.3) with NO.sub.2 Arg-Pro-Gly(NH.sub.2); certain peptide intermediates and their salts used in the production thereof; and the use thereof in the preparation of luteinizing hormone releasing factor.
    Type: Grant
    Filed: May 25, 1972
    Date of Patent: December 5, 1978
    Assignee: Parke, Davis & Company
    Inventors: Mildred C. Rebstock, Ernest D. Nicolaides, Thomas F. Mick, Francis J. Tinney, Eugene L. Wittle
  • Nonapeptides and methods for their production
    Patent number: 4124577
    Abstract: New nonapeptides having the formula R-Trp-Ser(benzyl)-Tyr(benzyl)-D-Phe-Leu-Arg(X)-Pro-Gly-Y wherein X is a protective group, R is pGlu, protected His(benzyl), protected Ser(benzyl) or protected Cys(benzyl), and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino.
    Type: Grant
    Filed: June 13, 1977
    Date of Patent: November 7, 1978
    Assignee: Warner-Lambert
    Inventors: Francis J. Tinney, Elizabeth A. Lunney, Ernest D. Nicolaides