Abstract: The present invention is directed to composite nanoparticles comprising a metal, a rare earth element, and, optionally, a complexing ligand. The invention is also directed to composite nanoparticles having a core-shell structure and to processes for preparation of composite nanoparticles of the invention.

Abstract: Various embodiments include systems and apparatuses adapted for detecting two-dimensional turbomachine exhaust temperature. In some embodiments, a system includes a two-dimensional grid sized to mount within an exhaust path of a gas turbomachine, a radiation detection device for detecting radiation emitted from the two-dimensional grid at a plurality of points on the two-dimensional grid, the radiation detection device being mountable proximate the exhaust path and the two-dimensional grid and at least one computing device connected with the radiation detection device, the at least one computing device configured to generate a planar map of the temperature of the exhaust from the gas turbomachine based upon the intensity of the radiation emitted from two-dimensional grid detected at the plurality of points on the two-dimensional grid.

Abstract: The present invention provides a method for in vivo delivery of endothal to a target cell in a subject, the method comprising administering to the subject a compound having the structure: Formula (I).

Abstract: The present invention provides a method of inhibiting the growth of or promoting differentiation and destruction of cancer stem cells (CSCs) comprising contacting the cancer stem cells with a compound having the structure: or a pharmaceutically acceptable salt thereof.

Abstract: A magnetic component including first and second regions, and a method of varying the magnetization values in different regions of the magnetic component are disclosed. The first and the second regions are characterized by a nitrogen content that is different from each other. At least one of the first region and the second region is partially-magnetic and has a nitrogen content in a range from about 0.1 weight % to about 0.4 weight % of that region. A concentration of carbon, if present, of both the first and second regions is less than about 0.05 weight % of the respective regions.

Abstract: A magnetic component including at least one region is disclosed. The at least one region includes nitrogen and a concentration of the nitrogen in the at least one region is graded across a dimension of the at least one region. Further, a saturation magnetization in the at least one region is graded across the dimension of the at least one region. Further, a method of varying the magnetization values in at least one region of the magnetic component is disclosed.

Abstract: A method of making a nanocomposite permanent magnet is provided. The method comprises applying an extreme shear deformation to hard magnetic phase nanoparticles and soft magnetic phase nanoparticles to align at least a portion of the hard phase magnetic particles and to produce a nanocomposite permanent magnet.

Abstract: A magneto-caloric assembly is provided. The assembly includes a first region comprising a first magneto-caloric material, a second region disposed on the first region and comprising a second magneto-caloric material and a first matrix material, and a third region disposed on the second region and comprising a thermally conductive material.

Abstract: A composition for destructive interference in at least a portion of the frequency range from about 1 GHz to about 20 GHz can comprise a dielectric and a conductive filler mixed with at least a portion of the dielectric, wherein the percentage volume of the conductive filler relative to the total volume of the composition is configured such that the wavelength of sensitivity for the composition is on the order of a wavelength of an incident electromagnetic radiation in at least a portion of the frequency range from about 1 GHz to about 20 GHz.

Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.

Abstract: A method of synthesizing magnetic nanoparticles comprising soft magnetic phases is provided, wherein the method comprises degassing a first mixture at a temperature in a range from about 80° C. to 130° C. The first mixture comprises a solvent, a compound comprising iron, cobalt, or combinations thereof dissolved in the solvent, and an organic component comprising a fatty acid or an amine. Degassing the first mixture is followed by adding a capping ligand to the first mixture under inert atmosphere to form a second mixture; adding a reducing agent to the second mixture at a temperature in a processing temperature range from about 250° C. to about 350° C. to form a third mixture; and incubating the third mixture at a temperature within the processing temperature range to form nanoparticles comprising a soft magnetic phase.

Abstract: Sanguinarine analogs as PP2C inhibitors are disclosed for the treatment of various cancers, as well as methods of synthesizing such analogs.

Abstract: The present invention provides a method of inhibiting the growth of or promoting differentiation and destruction of cancer stem cells (CSCs) comprising contacting the cancer stem cells with a compound having the structure: or a pharmaceutically acceptable salt thereof.

Abstract: A shell mold is described. The shell mold includes a facecoat, a sealcoat, and a support disposed in between the facecoat and the sealcoat. The support includes a stucco in a concentration greater than about 40 volume percent of the support. The stucco includes a material that has a thermal conductivity greater than about 285 W/m-K.

Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.

Abstract: A method of directionally solidifying a molten alloy is presented. The molten alloy is disposed in a shell mold that has a thermal conductivity value greater than about 2 W/m-K. During the direction solidification, heat is transferred from the shell mold to a cooling region with a heat extraction rate greater than about 120 W/m2.

Abstract: This invention provides compounds having the structure which may be used for the treatment of tumors.

Abstract: The present invention provides a method of inhibiting the growth of or promoting differentiation and destruction of cancer stem cells (CSCs) comprising contacting the cancer stem cells with a compound having the structure: or a pharmaceutically acceptable salt thereof.

Abstract: A shell mold is described. The shell mold includes a facecoat, a sealcoat, and a support disposed in between the facecoat and the sealcoat. The support includes a stucco in a concentration greater than about 40 volume percent of the support. The stucco includes a material that has a thermal conductivity greater than about 285 W/m-K.

Abstract: An article having a nanocomposite magnetic component and method of forming a nanocomposite magnetic component are disclosed. The article includes a plurality of nanocrystalline flake particles bonded along their prior particle boundaries. The nanocrystalline flake particles have a median grain size less than about 30 nanometers and include a first set of grains comprising predominantly permanent magnet phase and a second set of grains comprising predominantly soft magnet phase.