Abstract: The disclosure provides systems, devices, and associated methods for mitigating traumatic brain injury, injury to an ocular structure, or injury to the inner ear of a subject by applying pressure to one or more neck veins before and during an injurious event.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: Provided herein are synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof. Also provided herein are methods of treating and/or preventing Plasmodium infection and/or disease by administering the synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof.

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least sectionwise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: A system is disclosed for producing an output photon having a predefined frequency. The system comprises a frequency comb generator for generating a frequency comb. The system further comprises a frequency comb mode selector configured to: receive a heralding signal representative of the detection of a first photon of a frequency-correlated photon pair, the heralding signal indicative of a frequency of the heralded second photon of the frequency-correlated photon pair; and select, based on the received heralding signal, a comb spectral mode of the frequency comb. The system further comprises a non-linear photonic element configured to receive the heralded second photon and the selected comb spectral mode and produce an output photon having the predefined frequency based on the frequency of the heralded second photon and the selected comb spectral mode. Methods, controllers and computer-readable media are also described herein.

Abstract: A system is provided for producing an output photon having a predefined frequency. A pump module produces a plurality of pump fields at a plurality of pump frequencies. A photon pair source module generates frequency-correlated photon pairs. A detector module generates a heralding signal subsequent to detecting a first photon of a photon pair, the heralding signal indicative of a frequency of the second photon of the pair. A non-linear photonic element is arranged to (1) receive the heralded second photon and a complementary selected pump field, and (2) to produce an output photon having the predefined frequency. A pump field selector is configured to (1) receive a heralding signal and (2) select, based on the received heralding signal, a pump field of the plurality of pump fields for provision to the non-linear element. Methods, controllers and computer-readable media are also described herein.

Abstract: Systems and methods are disclosed for producing multi-layer meltblown mats. The method includes depositing first meltblown fibers onto a first moving surface such as a conveyor belt to form a first layer of meltblown fibers, and depositing second meltblown fibers onto a second moving surface such as a conveyor belt to form a second layer of meltblown fibers. The first and second layers of meltblown fibers are fed through opposed rollers to form combined meltblown layers comprising the first layer of meltblown fibers and the second layer of meltblown fibers. The combined meltblown layers are bonded together to produce a bonded multi-layer meltblown sheet. The bonded multi-layer meltblown sheet has a first outer exposed surface formed by contact of the first layer of meltblown fibers with the first moving surface, and a second outer exposed surface formed by contact of the second layer of meltblown fibers with the second moving surface.

Abstract: An apparatus has a plurality of photonic elements. At least two photonic elements forming a cavity. At least one photonic element receives first electromagnetic radiation from outside the cavity and transmits the first electromagnetic radiation into the photonic cavity. At least one photonic element receives second electromagnetic radiation from outside the cavity and transmits the second radiation into the photonic cavity. A photonic memory disposed in the cavity comprises an atomic system that: receives a photon field of first radiation; receives second radiation; stores at least a portion of the field of the photon in the atomic system via an atomic transition using the photon and the received second radiation; emits the stored portion of the photon upon receiving third electromagnetic radiation. The apparatus directs the photon into the photonic memory, after being reflected into the photonic cavity by at least one of the photonic elements; and outputs the emitted portion of the field into the cavity.

Abstract: An apparatus has a plurality of photonic elements. At least two photonic elements forming a cavity. At least one photonic element receives first electromagnetic radiation from outside the cavity and transmits the first electromagnetic radiation into the photonic cavity. At least one photonic element receives second electromagnetic radiation from outside the cavity and transmits the second radiation into the photonic cavity. A photonic memory disposed in the cavity comprises an atomic system that: receives a photon field of first radiation; receives second radiation; stores at least a portion of the field of the photon in the atomic system via an atomic transition using the photon and the received second radiation; emits the stored portion of the photon upon receiving third electromagnetic radiation. The apparatus directs the photon into the photonic memory, after being reflected into the photonic cavity by at least one of the photonic elements; and outputs the emitted portion of the field into the cavity.

Abstract: An apparatus is disclosed herein. The apparatus comprises a non-linear photonic element for outputting a signal and idler photon pair. The apparatus further comprises a module configured to, based on receiving one or more control signals, controllably store photons and controllably output stored photons. The apparatus further comprises a detector arrangement comprising one or more detectors for detecting light. The module is further configured to receive at least one of the signal and idler photons of the pair. The module is further configured to at least partially store one of the signal or idler photons of the pair. The module is further configured to output the said at least partially stored signal or idler photon along an optical path towards the at least one detectors. The apparatus is configured to direct the other of the signal or idler photon towards the detector arrangement.

Abstract: The present disclosure provides for processes and intermediates in the large-scale manufacture of the compound of formula (I) or hydrates thereof.

Abstract: The present disclosure provides for processes and intermediates in the large-scale manufacture of the compound of formula (I) or hydrates thereof.

Abstract: The present disclosure provides for processes and intermediates in the large-scale manufacture of the compound of formula (I) or hydrates thereof.

Abstract: A system for monitoring an endless belt conveyor, comprising a sensor for sensing a vibration of an idler roller and generating a signal corresponding to the sensed vibration, at least one of the frequency and amplitude of the generated signal being indicative of a condition of the idler roller, the sensor being integral with the endless belt conveyor.

Abstract: The present disclosure provides for processes and intermediates in the large-scale manufacture of the compound of formula (I) or hydrates thereof.

Abstract: A system for monitoring an endless belt conveyor, comprising a sensor for sensing a vibration of an idler roller and generating a signal corresponding to the sensed vibration, at least one of the frequency and amplitude of the generated signal being indicative of a condition of the idler roller, the sensor being integral with the endless belt conveyor.

Abstract: The present invention relates to a chemical process for the manufacture of a compound of Formula II

Abstract: This invention provides a deformable dispensing tube (1) with an internal device (8). The device is contained within the deformable dispensing tube but is a separate physical entity to the deformable dispensing tube and has the ability to move within the deformable dispensing tube. The object of the device is to aid the dispensing of part or all of the contents (16) of the deformable dispensing tube by the user.

Abstract: This invention provides a deformable dispensing tube (1) with an internal device (8). The device is contained within the deformable dispensing tube but is a separate physical entity to the deformable dispensing tube and has the ability to move within the deformable dispensing tube. The object of the device is to aid the dispensing of part or all of the contents (16) of the deformable dispensing tube by the user.