Abstract: A streetlight asset module (SAM) is provided including at least one memory block configured to store operating configuration settings of a streetlight associated with the SAM. The SAM is configured to communicate the operating configuration settings of the streetlight to a control and monitoring system (CMS) node coupled to the streetlight. The CMS node is configured to communicate the operating configuration settings to a remote location using a radio communications network. Related streetlights and systems are also provided.

Abstract: A device for emitting radiation includes a reflector component and a clip. The reflector component has a top side, a bottom side, and a perimeter side. At least one aperture formed within the reflector component that extends from a top opening on the top side of the reflector component through to a bottom opening on the bottom side of the reflector component. The clip may be connected to the reflector component and has a flat side that is in contact with the bottom side of the reflector component. Portions of the substantially flat side of the clip are configured to be soldered to a circuit board having an emitter which extends at least partially through the aperture when the clip is soldered to the circuit board.

Abstract: The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway.

Abstract: The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment. removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway.

Abstract: A radiation detector tile includes a single crystal compound semiconductor tile having a zinc blende crystal structure, a (111) plane first major (i.e. prominent) surface and four side surfaces which are rotated by an angle of 13° to 17° to a {110} family of planes. The tile may be formed by dicing a (111) oriented wafer at directions which are rotated by an angle of 13° to 17° from <110> in-plane slipping directions to reduce or eliminate the side surface chipping and sub surface dislocation defects.

Abstract: The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway.

Abstract: The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway.

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: Provided herein are novel compositions comprising anti-DEspR antibodies and fragments thereof derived from 6G8G7 and 7C5B2 anti-DEspR variant antibodies, including fully human, composite engineered human, humanized, monoclonal, and polyclonal anti-DEspR antibodies and fragments thereof, and methods of their use in a variety of therapeutic applications. The compositions comprising the anti-DEspR antibodies and fragments thereof described herein are useful in diagnostic and imaging methods, such as DEspR-targeted molecular imaging of angiogenesis, and for companion diagnostic and/or in vivo non-invasive imaging and/or assessments.

Abstract: Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-associated disorder or disease and methods of diagnosing a KIT-associated disorder or disease using the antibodies described herein.

Abstract: The Hybrid Learning Education Model (HLEM) is provided with an objective to ensure that learning is accessible, affordable, inclusive, developmental to educate learners beyond boundaries. Over many decades, teaching and learning was largely restricted to physical schools purely through face-to-face learning. The COVID-19 pandemic & subsequent lockdowns totally disrupted teaching & learning due to school closures announced by all countries globally. Technology in classroom was seen as one of the supplementary learning tools in education. Physical Schools and educational institutions held governance of student teaching & learning. Home schooling was seen in the dim light of educational progress towards sustenance. While Design Learning (DL) and outcome-based approach gained prominence, the Design Learning (DL) methods have been comprehensively used in various regions, there by assisting in teaching, learning, evaluation, and outcome-based assessment.

Abstract: An infuser for alcoholic beverages, having a container of ethyl alcohol and a water source, both of which are hydraulically connected to a volumetric mixing chamber, a water capsule holder located downstream of the volumetric chamber and intended to receive capsules containing single doses of essences, and extracting liquid from the volumetric chamber and injecting same into a capsule. The ethyl alcohol container and the water source are connected to the volumetric chamber by shut-off solenoid valves, and the volumetric chamber contains a main electrode and a plurality of secondary electrodes disposed above the main electrode at different levels.

Abstract: The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway.

Abstract: The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway.

Abstract: In some embodiments, a method receives a first signal that is sent in a first direction in a network. Communications in the network are full duplex communications in a same frequency band. The first signal is amplified in the first direction. The method trains a first echo canceller to cancel a first echo signal from the first signal where the first echo signal is received in a second direction. After training the first echo canceller, the trained first echo canceller is enabled. The method receives a second signal in the second direction that is sent in the second direction in the network. The second signal is amplified in the second direction. The method trains a second echo canceller to cancel a second echo signal received in the first direction from the second signal where the first echo canceller cancels the first echo signal that is received in the second direction.

Abstract: Systems and methods for implementing Soft-duplex functionality in an amplifier in a HFC network.

Abstract: Provided herein are compositions, methods and uses involving antibodies that specifically bind to MET, a receptor tyrosine kinase, and modulate the expression and/or activity of MET. Also provided are uses and methods for managing, treating, or preventing disorders, such as cancer. In one aspect, provided herein is a monoclonal antibody or antigen-binding fragment thereof that binds to the Sema/PSI domain of human MET. Also provided herein is a kit comprising an antibody or antigen-binding fragment provided herein. Also provided herein is a method of managing, protecting against, or treating cancer in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of an antibody or antigen-binding fragment provided herein.

Abstract: An electro-optic modulator includes a doped semiconductor crystal having a crystallographic surface having an amplitude modulation orientation, a first metal electrode located on a first surface of the doped semiconductor crystal, a second metal electrode located on a second surface of the doped semiconductor crystal, and accumulation space charge regions located within surface regions of the doped semiconductor crystal that are proximal to the first metal electrode and the second metal electrode and including excess charge carriers of a same type as majority charge carriers of the doped semiconductor crystal.

Abstract: A device for emitting radiation includes a reflector component and a clip. The reflector component has a top side, a bottom side, and a perimeter side. At least one aperture formed within the reflector component that extends from a top opening on the top side of the reflector component through to a bottom opening on the bottom side of the reflector component. The clip may be connected to the reflector component and has a flat side that is in contact with the bottom side of the reflector component. Portions of the substantially flat side of the clip are configured to be soldered to a circuit board having an emitter which extends at least partially through the aperture when the clip is soldered to the circuit board.

Abstract: A device for emitting radiation includes a housing defining a cavity, an electrical connector formed on the housing, a heatsink having a flange, a circuit board located in the cavity having an emitter, and a filter located adjacent to the circuit board and opposite of the heatsink. The filter has at least one post that extends through a hole formed on the circuit board and through a hole formed on a flange of the heatsink. The at least one post has a press-fit termination end that engages the hole of the heatsink. The housing may be over-molded onto the heatsink.