Patents by Inventor Francis Kappler

Francis Kappler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for assessing risk of diabetes-associated pathologic conditions and efficacy of therapies for such conditions
    Patent number: 5231031
    Abstract: Concentrations of one or more carbohydrates phosphorylated at a secondary hydroxyl, including fructose-3-phosphate and sorbitol-3-phosphate, in biological tissue or cells of diabetic patients are determined by .sup.31 P NMR Spectroscopy, High Performance Liquid Chromatography (HPLC) or other appropriate analytical techniques. Elevated levels of such phosphorylated carbohydrates, relative to a prescribed standard or threshold level, are associated with an increased risk for developing the degenerative complications of diabetes. A method is provided for determining the relative concentrations of such phosphorylated carbohydrates, whereby the relative risk of a patient for the development of diabetic complications and the efficacy of therapeutic intervention in prevention of such complications may be assessed.
    Type: Grant
    Filed: August 17, 1990
    Date of Patent: July 27, 1993
    Assignee: Fox Chase Cancer Center
    Inventors: Benjamin S. Szwergold, Truman R. Brown, Francis Kappler, Aqqaluk Peterson